Mitochondrial damage and activation of the cytosolic DNA sensor cGAS–STING pathway lead to cardiac pyroptosis and hypertrophy in diabetic cardiomyopathy mice

Mitochondrial damage and activation of the cytosolic DNA sensor cGAS–STING pathway lead to cardiac pyroptosis and hypertrophy in diabetic cardiomyopathy mice

Abstract Diabetic cardiomyopathy (DCM) is a serious cardiac complication of diabetes that currently lacks specific treatment. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway has been suggested to contribute to the pathogenesis of cardiovascular diseases. H...

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Bibliographic Details
Main Authors: Meiling Yan, Yun Li, Qingmao Luo, Wenru Zeng, Xiaoqi Shao, Lun Li, Qing Wang, Dongwei Wang, Yue Zhang, Hongtao Diao, Xianglu Rong, Yunlong Bai, Jiao Guo
Format: Article
Language:English
Published: Nature Publishing Group 2022-05-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-01046-w

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