Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors
Circulating tumor cells (CTCs) have emerged as pivotal biomarkers with significant predictive and prognostic implications in solid tumors. Their presence in peripheral blood offers a non-invasive window into the dynamic landscape of cancer progression and treatment response. This narrative literatur...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/22/2590 |
| _version_ | 1827640303362768896 |
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| author | Maurizio Capuozzo Francesco Ferrara Mariachiara Santorsola Andrea Zovi Alessandro Ottaiano |
| author_facet | Maurizio Capuozzo Francesco Ferrara Mariachiara Santorsola Andrea Zovi Alessandro Ottaiano |
| author_sort | Maurizio Capuozzo |
| collection | DOAJ |
| description | Circulating tumor cells (CTCs) have emerged as pivotal biomarkers with significant predictive and prognostic implications in solid tumors. Their presence in peripheral blood offers a non-invasive window into the dynamic landscape of cancer progression and treatment response. This narrative literature review synthesizes the current state of knowledge surrounding the multifaceted role of CTCs in predicting clinical outcomes and informing prognosis across a spectrum of solid tumor malignancies. This review delves into the evolving landscape of CTC-based research, emphasizing their potential as early indicators of disease recurrence, metastatic potential, and therapeutic resistance. Moreover, we have underscored the dynamic nature of CTCs and their implications for personalized medicine. A descriptive and critical analysis of CTC detection methodologies, their clinical relevance, and their associated challenges is also presented, with a focus on recent advancements and emerging technologies. Furthermore, we examine the integration of CTC-based liquid biopsies into clinical practice, highlighting their role in guiding treatment decisions, monitoring treatment efficacy, and facilitating precision oncology. This review highlights the transformative impact of CTCs as predictive and prognostic biomarkers in the management of solid tumors by promoting a deeper understanding of the clinical relevance of CTCs and their role in advancing the field of oncology. |
| first_indexed | 2024-03-09T16:56:56Z |
| format | Article |
| id | doaj.art-af0be81789644a4494b889db33216675 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T16:56:56Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-af0be81789644a4494b889db332166752023-11-24T14:35:10ZengMDPI AGCells2073-44092023-11-011222259010.3390/cells12222590Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid TumorsMaurizio Capuozzo0Francesco Ferrara1Mariachiara Santorsola2Andrea Zovi3Alessandro Ottaiano4Coordinamento Farmaceutico, ASL-Naples-3, 80056 Ercolano, ItalyCoordinamento Farmaceutico, ASL-Naples-3, 80056 Ercolano, ItalyIstituto Nazionale Tumori di Napoli, IRCCS “G. Pascale”, Via M. Semmola, 80131 Naples, ItalyMinistry of Health, Viale Giorgio Ribotta 5, 00144 Rome, ItalyIstituto Nazionale Tumori di Napoli, IRCCS “G. Pascale”, Via M. Semmola, 80131 Naples, ItalyCirculating tumor cells (CTCs) have emerged as pivotal biomarkers with significant predictive and prognostic implications in solid tumors. Their presence in peripheral blood offers a non-invasive window into the dynamic landscape of cancer progression and treatment response. This narrative literature review synthesizes the current state of knowledge surrounding the multifaceted role of CTCs in predicting clinical outcomes and informing prognosis across a spectrum of solid tumor malignancies. This review delves into the evolving landscape of CTC-based research, emphasizing their potential as early indicators of disease recurrence, metastatic potential, and therapeutic resistance. Moreover, we have underscored the dynamic nature of CTCs and their implications for personalized medicine. A descriptive and critical analysis of CTC detection methodologies, their clinical relevance, and their associated challenges is also presented, with a focus on recent advancements and emerging technologies. Furthermore, we examine the integration of CTC-based liquid biopsies into clinical practice, highlighting their role in guiding treatment decisions, monitoring treatment efficacy, and facilitating precision oncology. This review highlights the transformative impact of CTCs as predictive and prognostic biomarkers in the management of solid tumors by promoting a deeper understanding of the clinical relevance of CTCs and their role in advancing the field of oncology.https://www.mdpi.com/2073-4409/12/22/2590circulating tumor cellscancer geneticsprognosisbiomarkerstumor heterogeneity |
| spellingShingle | Maurizio Capuozzo Francesco Ferrara Mariachiara Santorsola Andrea Zovi Alessandro Ottaiano Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors Cells circulating tumor cells cancer genetics prognosis biomarkers tumor heterogeneity |
| title | Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors |
| title_full | Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors |
| title_fullStr | Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors |
| title_full_unstemmed | Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors |
| title_short | Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors |
| title_sort | circulating tumor cells as predictive and prognostic biomarkers in solid tumors |
| topic | circulating tumor cells cancer genetics prognosis biomarkers tumor heterogeneity |
| url | https://www.mdpi.com/2073-4409/12/22/2590 |
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