Functional Correlates of Striatal Dopamine Transporter Cerebrospinal Fluid Levels in Alzheimer’s Disease: A Preliminary <sup>18</sup>F-FDG PET/CT Study
The aim of our study was to investigate regional glucose metabolism with 18F-FDG positron emission tomography/computed tomography in a population of patients with Alzheimer’s disease (AD) in relation to cerebrospinal (CSF) levels of striatal dopamine transporter (DAT). All patients underwent lumbar...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/1/751 |
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| author | Riccardo Camedda Chiara Giuseppina Bonomi Martina Gaia Di Donna Agostino Chiaravalloti |
| author_facet | Riccardo Camedda Chiara Giuseppina Bonomi Martina Gaia Di Donna Agostino Chiaravalloti |
| author_sort | Riccardo Camedda |
| collection | DOAJ |
| description | The aim of our study was to investigate regional glucose metabolism with 18F-FDG positron emission tomography/computed tomography in a population of patients with Alzheimer’s disease (AD) in relation to cerebrospinal (CSF) levels of striatal dopamine transporter (DAT). All patients underwent lumbar puncture and received a biomarker-based diagnosis of AD. Differences in regional brain glucose metabolism were assessed by Statistical Parametric Mapping version 12 with the use of age, gender, and MMSE as covariates in the analysis. A positive correlation between CSF DAT levels and glucose metabolism at the level of two brain areas involved in the pathophysiological process of Alzheimer’s disease, the substantia nigra and the posterior cingulate gyrus, has been highlighted. Results indicate that patients with higher CSF DAT levels have a better metabolic pattern in two key zones, suggesting less advanced disease status in patients with more conserved dopaminergic systems. |
| first_indexed | 2024-03-11T09:58:08Z |
| format | Article |
| id | doaj.art-af0cd58e285a4198a7e814d956cf4e7d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:58:08Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-af0cd58e285a4198a7e814d956cf4e7d2023-11-16T15:37:56ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-0124175110.3390/ijms24010751Functional Correlates of Striatal Dopamine Transporter Cerebrospinal Fluid Levels in Alzheimer’s Disease: A Preliminary <sup>18</sup>F-FDG PET/CT StudyRiccardo Camedda0Chiara Giuseppina Bonomi1Martina Gaia Di Donna2Agostino Chiaravalloti3Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyMemory Clinic, Policlinico Tor Vergata, University of Rome, 00133 Rome, ItalyMemory Clinic, Policlinico Tor Vergata, University of Rome, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyThe aim of our study was to investigate regional glucose metabolism with 18F-FDG positron emission tomography/computed tomography in a population of patients with Alzheimer’s disease (AD) in relation to cerebrospinal (CSF) levels of striatal dopamine transporter (DAT). All patients underwent lumbar puncture and received a biomarker-based diagnosis of AD. Differences in regional brain glucose metabolism were assessed by Statistical Parametric Mapping version 12 with the use of age, gender, and MMSE as covariates in the analysis. A positive correlation between CSF DAT levels and glucose metabolism at the level of two brain areas involved in the pathophysiological process of Alzheimer’s disease, the substantia nigra and the posterior cingulate gyrus, has been highlighted. Results indicate that patients with higher CSF DAT levels have a better metabolic pattern in two key zones, suggesting less advanced disease status in patients with more conserved dopaminergic systems.https://www.mdpi.com/1422-0067/24/1/751FDG-PETDATAlzheimer’s diseasedopaminergic impairmentdementia |
| spellingShingle | Riccardo Camedda Chiara Giuseppina Bonomi Martina Gaia Di Donna Agostino Chiaravalloti Functional Correlates of Striatal Dopamine Transporter Cerebrospinal Fluid Levels in Alzheimer’s Disease: A Preliminary <sup>18</sup>F-FDG PET/CT Study International Journal of Molecular Sciences FDG-PET DAT Alzheimer’s disease dopaminergic impairment dementia |
| title | Functional Correlates of Striatal Dopamine Transporter Cerebrospinal Fluid Levels in Alzheimer’s Disease: A Preliminary <sup>18</sup>F-FDG PET/CT Study |
| title_full | Functional Correlates of Striatal Dopamine Transporter Cerebrospinal Fluid Levels in Alzheimer’s Disease: A Preliminary <sup>18</sup>F-FDG PET/CT Study |
| title_fullStr | Functional Correlates of Striatal Dopamine Transporter Cerebrospinal Fluid Levels in Alzheimer’s Disease: A Preliminary <sup>18</sup>F-FDG PET/CT Study |
| title_full_unstemmed | Functional Correlates of Striatal Dopamine Transporter Cerebrospinal Fluid Levels in Alzheimer’s Disease: A Preliminary <sup>18</sup>F-FDG PET/CT Study |
| title_short | Functional Correlates of Striatal Dopamine Transporter Cerebrospinal Fluid Levels in Alzheimer’s Disease: A Preliminary <sup>18</sup>F-FDG PET/CT Study |
| title_sort | functional correlates of striatal dopamine transporter cerebrospinal fluid levels in alzheimer s disease a preliminary sup 18 sup f fdg pet ct study |
| topic | FDG-PET DAT Alzheimer’s disease dopaminergic impairment dementia |
| url | https://www.mdpi.com/1422-0067/24/1/751 |
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