Challenges in the Diagnosis of Parathyroid Cancer: Unraveling the Diagnostic Maze
Parathyroid carcinoma (PC) is a rare and aggressive cancer affecting the parathyroid glands, presenting diagnostic and therapeutic challenges due to its rarity and overlapping features with benign parathyroid disease. This report describes the case of a 51-year-old patient with significantly elevate...
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MDPI AG
2023-08-01
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| Series: | Reports |
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| Online Access: | https://www.mdpi.com/2571-841X/6/3/40 |
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| author | Mihaela Stanciu Remus Calin Cipaian Ruxandra Ristea Corina Maria Vasile Mihaela Popescu Florina Ligia Popa |
| author_facet | Mihaela Stanciu Remus Calin Cipaian Ruxandra Ristea Corina Maria Vasile Mihaela Popescu Florina Ligia Popa |
| author_sort | Mihaela Stanciu |
| collection | DOAJ |
| description | Parathyroid carcinoma (PC) is a rare and aggressive cancer affecting the parathyroid glands, presenting diagnostic and therapeutic challenges due to its rarity and overlapping features with benign parathyroid disease. This report describes the case of a 51-year-old patient with significantly elevated serum calcium levels, leading to further investigation. Imaging studies revealed a large nodular mass in the right inferior parathyroid gland. After undergoing right inferior parathyroidectomy, pathology confirmed parathyroid carcinoma. However, the patient experienced a relapse, detected via a neck MRI. This case highlights the importance of specific clinical features, such as rapid calcium increase, elevated parathyroid hormone (PTH) levels, and a large nodular mass, in suspecting malignancy. Differential diagnosis between carcinoma and adenoma can be challenging, and immunohistochemistry aids in diagnosis. Regular follow-up with calcium and PTH monitoring is essential for detecting recurrence. This case underscores the aggressive nature of parathyroid carcinoma and the importance of early diagnosis, surgical intervention, and thorough follow-up care for improved outcomes. |
| first_indexed | 2024-03-10T22:04:40Z |
| format | Article |
| id | doaj.art-af0cf42ad6294b819103e49ae7b83d93 |
| institution | Directory Open Access Journal |
| issn | 2571-841X |
| language | English |
| last_indexed | 2024-03-10T22:04:40Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Reports |
| spelling | doaj.art-af0cf42ad6294b819103e49ae7b83d932023-11-19T12:50:46ZengMDPI AGReports2571-841X2023-08-01634010.3390/reports6030040Challenges in the Diagnosis of Parathyroid Cancer: Unraveling the Diagnostic MazeMihaela Stanciu0Remus Calin Cipaian1Ruxandra Ristea2Corina Maria Vasile3Mihaela Popescu4Florina Ligia Popa5Department of Endocrinology, County Clinical Emergency Hospital of Sibiu, 550245 Sibiu, RomaniaDepartment of Internal Medicine, Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, RomaniaDepartment of Endocrinology, County Clinical Emergency Hospital of Sibiu, 550245 Sibiu, RomaniaDepartment of Pediatric and Adult Congenital Cardiology, Bordeaux University Hospital, 33600 Pessac, FranceDepartment of Endocrinology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Physical Medicine and Rehabilitation, Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, RomaniaParathyroid carcinoma (PC) is a rare and aggressive cancer affecting the parathyroid glands, presenting diagnostic and therapeutic challenges due to its rarity and overlapping features with benign parathyroid disease. This report describes the case of a 51-year-old patient with significantly elevated serum calcium levels, leading to further investigation. Imaging studies revealed a large nodular mass in the right inferior parathyroid gland. After undergoing right inferior parathyroidectomy, pathology confirmed parathyroid carcinoma. However, the patient experienced a relapse, detected via a neck MRI. This case highlights the importance of specific clinical features, such as rapid calcium increase, elevated parathyroid hormone (PTH) levels, and a large nodular mass, in suspecting malignancy. Differential diagnosis between carcinoma and adenoma can be challenging, and immunohistochemistry aids in diagnosis. Regular follow-up with calcium and PTH monitoring is essential for detecting recurrence. This case underscores the aggressive nature of parathyroid carcinoma and the importance of early diagnosis, surgical intervention, and thorough follow-up care for improved outcomes.https://www.mdpi.com/2571-841X/6/3/40parathyroid carcinomaparathyroid hormoneearly diagnosis |
| spellingShingle | Mihaela Stanciu Remus Calin Cipaian Ruxandra Ristea Corina Maria Vasile Mihaela Popescu Florina Ligia Popa Challenges in the Diagnosis of Parathyroid Cancer: Unraveling the Diagnostic Maze Reports parathyroid carcinoma parathyroid hormone early diagnosis |
| title | Challenges in the Diagnosis of Parathyroid Cancer: Unraveling the Diagnostic Maze |
| title_full | Challenges in the Diagnosis of Parathyroid Cancer: Unraveling the Diagnostic Maze |
| title_fullStr | Challenges in the Diagnosis of Parathyroid Cancer: Unraveling the Diagnostic Maze |
| title_full_unstemmed | Challenges in the Diagnosis of Parathyroid Cancer: Unraveling the Diagnostic Maze |
| title_short | Challenges in the Diagnosis of Parathyroid Cancer: Unraveling the Diagnostic Maze |
| title_sort | challenges in the diagnosis of parathyroid cancer unraveling the diagnostic maze |
| topic | parathyroid carcinoma parathyroid hormone early diagnosis |
| url | https://www.mdpi.com/2571-841X/6/3/40 |
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