18F-FDG-PET/CT in radiation therapy-induced parotid gland inflammation
Abstract Background 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) is used in the clinical management of oncologic and inflammatory pathologies. It may have utility in detecting radiotherapy (RT)-induced damage of oral tissues. Thus, the aim of the present study...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-12-01
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| Series: | European Journal of Hybrid Imaging |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41824-020-00091-x |
| _version_ | 1818602368250413056 |
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| author | Alaa Mouminah Austin J. Borja Emily C. Hancin Yu Cheng Chang Thomas J. Werner Samuel Swisher-McClure Jonathan Korostoff Abass Alavi Mona-Elisabeth Revheim |
| author_facet | Alaa Mouminah Austin J. Borja Emily C. Hancin Yu Cheng Chang Thomas J. Werner Samuel Swisher-McClure Jonathan Korostoff Abass Alavi Mona-Elisabeth Revheim |
| author_sort | Alaa Mouminah |
| collection | DOAJ |
| description | Abstract Background 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) is used in the clinical management of oncologic and inflammatory pathologies. It may have utility in detecting radiotherapy (RT)-induced damage of oral tissues. Thus, the aim of the present study was to use FDG-PET/CT to evaluate parotid gland inflammation following RT in patients with head and neck cancer (HNC). Methods This retrospective study included patients with HNC treated with photon, proton, or combined photon/proton RT, in addition to chemotherapy. All patients received FDG-PET/CT imaging pre-treatment and 3 months post-treatment. The average mean standardized uptake value (Avg SUVmean) and the average maximum standardized uptake value (Avg SUVmax) of the left and right parotid glands were determined by global assessment of FDG activity using OsiriX MD software. A two-tailed paired t test was used to compare Avg SUVmean and Avg SUVmax pre- and post-RT. Results Forty-seven HNC patients were included in the study. Parotid gland Avg SUVmean was significantly higher at 3 months post-treatment than pre-treatment (p < 0.05) in patients treated with photon RT, but no significant differences were found between pre- and post-treatment Avg SUVmean in patients treated with proton RT or combined photon/proton RT. Conclusion Our results suggest that photon RT may cause radiation-induced inflammation of the parotid gland, and that proton RT, which distributes less off-target radiation, is a safer treatment alternative. |
| first_indexed | 2024-12-16T13:06:10Z |
| format | Article |
| id | doaj.art-af0d82911e9644c080fb0052bda8c739 |
| institution | Directory Open Access Journal |
| issn | 2510-3636 |
| language | English |
| last_indexed | 2024-12-16T13:06:10Z |
| publishDate | 2020-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | European Journal of Hybrid Imaging |
| spelling | doaj.art-af0d82911e9644c080fb0052bda8c7392022-12-21T22:30:44ZengSpringerOpenEuropean Journal of Hybrid Imaging2510-36362020-12-014111010.1186/s41824-020-00091-x18F-FDG-PET/CT in radiation therapy-induced parotid gland inflammationAlaa Mouminah0Austin J. Borja1Emily C. Hancin2Yu Cheng Chang3Thomas J. Werner4Samuel Swisher-McClure5Jonathan Korostoff6Abass Alavi7Mona-Elisabeth Revheim8Department of Radiology, University of PennsylvaniaDepartment of Radiology, University of PennsylvaniaDepartment of Radiology, University of PennsylvaniaThe University of Pennsylvania School of Dental MedicineDepartment of Radiology, University of PennsylvaniaDepartment of Radiation Oncology, University of PennsylvaniaThe University of Pennsylvania School of Dental MedicineDepartment of Radiology, University of PennsylvaniaDepartment of Radiology, University of PennsylvaniaAbstract Background 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) is used in the clinical management of oncologic and inflammatory pathologies. It may have utility in detecting radiotherapy (RT)-induced damage of oral tissues. Thus, the aim of the present study was to use FDG-PET/CT to evaluate parotid gland inflammation following RT in patients with head and neck cancer (HNC). Methods This retrospective study included patients with HNC treated with photon, proton, or combined photon/proton RT, in addition to chemotherapy. All patients received FDG-PET/CT imaging pre-treatment and 3 months post-treatment. The average mean standardized uptake value (Avg SUVmean) and the average maximum standardized uptake value (Avg SUVmax) of the left and right parotid glands were determined by global assessment of FDG activity using OsiriX MD software. A two-tailed paired t test was used to compare Avg SUVmean and Avg SUVmax pre- and post-RT. Results Forty-seven HNC patients were included in the study. Parotid gland Avg SUVmean was significantly higher at 3 months post-treatment than pre-treatment (p < 0.05) in patients treated with photon RT, but no significant differences were found between pre- and post-treatment Avg SUVmean in patients treated with proton RT or combined photon/proton RT. Conclusion Our results suggest that photon RT may cause radiation-induced inflammation of the parotid gland, and that proton RT, which distributes less off-target radiation, is a safer treatment alternative.https://doi.org/10.1186/s41824-020-00091-xPET/CT18F-FDGRadiation therapyParotid glandParotid gland inflammationHead and neck cancer |
| spellingShingle | Alaa Mouminah Austin J. Borja Emily C. Hancin Yu Cheng Chang Thomas J. Werner Samuel Swisher-McClure Jonathan Korostoff Abass Alavi Mona-Elisabeth Revheim 18F-FDG-PET/CT in radiation therapy-induced parotid gland inflammation European Journal of Hybrid Imaging PET/CT 18F-FDG Radiation therapy Parotid gland Parotid gland inflammation Head and neck cancer |
| title | 18F-FDG-PET/CT in radiation therapy-induced parotid gland inflammation |
| title_full | 18F-FDG-PET/CT in radiation therapy-induced parotid gland inflammation |
| title_fullStr | 18F-FDG-PET/CT in radiation therapy-induced parotid gland inflammation |
| title_full_unstemmed | 18F-FDG-PET/CT in radiation therapy-induced parotid gland inflammation |
| title_short | 18F-FDG-PET/CT in radiation therapy-induced parotid gland inflammation |
| title_sort | 18f fdg pet ct in radiation therapy induced parotid gland inflammation |
| topic | PET/CT 18F-FDG Radiation therapy Parotid gland Parotid gland inflammation Head and neck cancer |
| url | https://doi.org/10.1186/s41824-020-00091-x |
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