Mechanism of action of mRNA-based vaccines
Introduction: The present review summarizes the growing body of work defining the mechanisms of action of this exciting new vaccine technology that should allow rational approaches in the design of next generation mRNA vaccines. Areas covered: Bio-distribution of mRNA, localization of antigen produc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-09-01
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| Series: | Expert Review of Vaccines |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/14760584.2017.1355245 |
| _version_ | 1797680440742510592 |
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| author | Carlo Iavarone Derek T. O’hagan Dong Yu Nicolas F. Delahaye Jeffrey B. Ulmer |
| author_facet | Carlo Iavarone Derek T. O’hagan Dong Yu Nicolas F. Delahaye Jeffrey B. Ulmer |
| author_sort | Carlo Iavarone |
| collection | DOAJ |
| description | Introduction: The present review summarizes the growing body of work defining the mechanisms of action of this exciting new vaccine technology that should allow rational approaches in the design of next generation mRNA vaccines. Areas covered: Bio-distribution of mRNA, localization of antigen production, role of the innate immunity, priming of the adaptive immune response, route of administration and effects of mRNA delivery systems. Expert commentary: In the last few years, the development of RNA vaccines had a fast growth, the rising number of proof will enable rational approaches to improving the effectiveness and safety of this modern class of medicine. |
| first_indexed | 2024-03-11T23:30:04Z |
| format | Article |
| id | doaj.art-af0fd2c6700e471485016843d9b2aaab |
| institution | Directory Open Access Journal |
| issn | 1476-0584 1744-8395 |
| language | English |
| last_indexed | 2024-03-11T23:30:04Z |
| publishDate | 2017-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Expert Review of Vaccines |
| spelling | doaj.art-af0fd2c6700e471485016843d9b2aaab2023-09-20T10:18:02ZengTaylor & Francis GroupExpert Review of Vaccines1476-05841744-83952017-09-0116987188110.1080/14760584.2017.13552451355245Mechanism of action of mRNA-based vaccinesCarlo Iavarone0Derek T. O’hagan1Dong Yu2Nicolas F. Delahaye3Jeffrey B. Ulmer4GSK VaccinesGSK VaccinesGSK VaccinesGSK VaccinesGSK VaccinesIntroduction: The present review summarizes the growing body of work defining the mechanisms of action of this exciting new vaccine technology that should allow rational approaches in the design of next generation mRNA vaccines. Areas covered: Bio-distribution of mRNA, localization of antigen production, role of the innate immunity, priming of the adaptive immune response, route of administration and effects of mRNA delivery systems. Expert commentary: In the last few years, the development of RNA vaccines had a fast growth, the rising number of proof will enable rational approaches to improving the effectiveness and safety of this modern class of medicine.http://dx.doi.org/10.1080/14760584.2017.1355245intrinsic adjuvanticityinnate immunityantiviral responsetype i interferondelivery systemoptimizationself-amplifying mrna (sam) |
| spellingShingle | Carlo Iavarone Derek T. O’hagan Dong Yu Nicolas F. Delahaye Jeffrey B. Ulmer Mechanism of action of mRNA-based vaccines Expert Review of Vaccines intrinsic adjuvanticity innate immunity antiviral response type i interferon delivery system optimization self-amplifying mrna (sam) |
| title | Mechanism of action of mRNA-based vaccines |
| title_full | Mechanism of action of mRNA-based vaccines |
| title_fullStr | Mechanism of action of mRNA-based vaccines |
| title_full_unstemmed | Mechanism of action of mRNA-based vaccines |
| title_short | Mechanism of action of mRNA-based vaccines |
| title_sort | mechanism of action of mrna based vaccines |
| topic | intrinsic adjuvanticity innate immunity antiviral response type i interferon delivery system optimization self-amplifying mrna (sam) |
| url | http://dx.doi.org/10.1080/14760584.2017.1355245 |
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