Lipid Profile and Antihypertensive Drugs
Background: Hypertension and dyslipidemia are cardiovascular risk factors that commonly coexist . Objective : To evaluate the effects of ß - blocker (Atenolol) , ACE inhibitor (Captopril) calcium Channel blocker (Nefidipin ) and diuretics on serum lipid profiles . Method: Thirty untreated hypertens...
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| Format: | Article |
| Language: | English |
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University of Baghdad/ Al-Kindy College of Medicine
2009-06-01
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| Series: | مجله كليه طب الكندي |
| Subjects: | |
| Online Access: | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/713 |
| Summary: | Background: Hypertension and dyslipidemia are
cardiovascular risk factors that commonly coexist .
Objective : To evaluate the effects of ß - blocker
(Atenolol) , ACE inhibitor (Captopril) calcium Channel
blocker (Nefidipin ) and diuretics on serum lipid profiles .
Method: Thirty untreated hypertensive and 147
hypertensive patient treated with these antihypertensive
drugs, attending different public health clinics in Basrah
pronivce were enrolled in this study .
Serum lipid profile were determined enzymaticaly using kits
from BioMerieux, France .
Result : The study has revealed that ß-blocker do not
significantly affect total cholesterol ( TC ) and LDLcholesterol , but increase significantly triglyceride (TG) and
VLDL – cholesterol and decrease HDL – cholesterol.
Diuretics causes a significant elevation of TG with generally
no significant changes in TC , LDL – cholesterol , VLDL –
cholesterol and HDL-cholesterol. ACE inhibitor and calcium
channel blockers appears to have no significant effect on
plasma lipids .
Conclusion :It may important to measure blood lipid levels
to identify pre-existing hyperlipidemia before starting the
antihypertensive therapy and to select antihypertensive agent
that will not influence the lipid profile or interfere with the
therapy of hyperlipidemi
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| ISSN: | 1810-9543 2521-4365 |