The Role of microRNAs in the Cisplatin- and Radio-Resistance of Cervical Cancer
Cervical cancer is the fourth leading cause of cancer-related death among women worldwide. The chemotherapeutical agent cisplatin, a small platinum-based compound, is considered as the standard therapy for locally advanced cervical cancer or recurrent cancers, sometimes in combination with radiother...
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| Format: | Article |
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MDPI AG
2021-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/5/1168 |
| _version_ | 1797542135126294528 |
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| author | Rina Masadah Syahrul Rauf Muhammad Yogi Pratama Claudio Tiribelli Devis Pascut |
| author_facet | Rina Masadah Syahrul Rauf Muhammad Yogi Pratama Claudio Tiribelli Devis Pascut |
| author_sort | Rina Masadah |
| collection | DOAJ |
| description | Cervical cancer is the fourth leading cause of cancer-related death among women worldwide. The chemotherapeutical agent cisplatin, a small platinum-based compound, is considered as the standard therapy for locally advanced cervical cancer or recurrent cancers, sometimes in combination with radiotherapy or other drugs. However, drug resistance and radio-resistance phenomena could reduce the life expectancy of cervical cancer patients. Resistance mechanisms are complex and often involve multiple cellular pathways in which microRNAs (miRNAs) play a fundamental role. miRNAs are a class of endogenous non-coding small RNAs responsible for post-transcriptional gene regulation. Convincing evidence demonstrates that several deregulated miRNAs are important regulators in the onset of drug and radioresistance in cervical cancer, thus underlying their potential applications in a clinical setting. In this review, we summarized the mechanisms by which miRNAs affect both cisplatin and radioresistance in cervical cancer. We also described the regulatory loops between miRNAs and lncRNAs promoting drug resistance. Besides, we reported evidence for the role of miRNAs in sensitizing cancer cells to cisplatin-based chemotherapy, and provided some suggestions for the development of new combined therapies for cervical cancer. |
| first_indexed | 2024-03-10T13:25:25Z |
| format | Article |
| id | doaj.art-af10f8fdc2c54a9bb0b8cf0f703fb8a8 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T13:25:25Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-af10f8fdc2c54a9bb0b8cf0f703fb8a82023-11-21T09:41:16ZengMDPI AGCancers2072-66942021-03-01135116810.3390/cancers13051168The Role of microRNAs in the Cisplatin- and Radio-Resistance of Cervical CancerRina Masadah0Syahrul Rauf1Muhammad Yogi Pratama2Claudio Tiribelli3Devis Pascut4Department of Pathology Anatomy, Hasanuddin University, Makassar 90245, IndonesiaDepartment of Obstetrics and Gynecology, Hasanuddin University, Makassar 90245, IndonesiaDepartment of Pathology Anatomy, Hasanuddin University, Makassar 90245, IndonesiaLiver Research Center, Fondazione Italiana Fegato—ONLUS, Basovizza, 34149 Trieste, ItalyLiver Research Center, Fondazione Italiana Fegato—ONLUS, Basovizza, 34149 Trieste, ItalyCervical cancer is the fourth leading cause of cancer-related death among women worldwide. The chemotherapeutical agent cisplatin, a small platinum-based compound, is considered as the standard therapy for locally advanced cervical cancer or recurrent cancers, sometimes in combination with radiotherapy or other drugs. However, drug resistance and radio-resistance phenomena could reduce the life expectancy of cervical cancer patients. Resistance mechanisms are complex and often involve multiple cellular pathways in which microRNAs (miRNAs) play a fundamental role. miRNAs are a class of endogenous non-coding small RNAs responsible for post-transcriptional gene regulation. Convincing evidence demonstrates that several deregulated miRNAs are important regulators in the onset of drug and radioresistance in cervical cancer, thus underlying their potential applications in a clinical setting. In this review, we summarized the mechanisms by which miRNAs affect both cisplatin and radioresistance in cervical cancer. We also described the regulatory loops between miRNAs and lncRNAs promoting drug resistance. Besides, we reported evidence for the role of miRNAs in sensitizing cancer cells to cisplatin-based chemotherapy, and provided some suggestions for the development of new combined therapies for cervical cancer.https://www.mdpi.com/2072-6694/13/5/1168cervical cancercisplatinmicroRNAdrug resistanceradiotherapycisplatin resistance |
| spellingShingle | Rina Masadah Syahrul Rauf Muhammad Yogi Pratama Claudio Tiribelli Devis Pascut The Role of microRNAs in the Cisplatin- and Radio-Resistance of Cervical Cancer Cancers cervical cancer cisplatin microRNA drug resistance radiotherapy cisplatin resistance |
| title | The Role of microRNAs in the Cisplatin- and Radio-Resistance of Cervical Cancer |
| title_full | The Role of microRNAs in the Cisplatin- and Radio-Resistance of Cervical Cancer |
| title_fullStr | The Role of microRNAs in the Cisplatin- and Radio-Resistance of Cervical Cancer |
| title_full_unstemmed | The Role of microRNAs in the Cisplatin- and Radio-Resistance of Cervical Cancer |
| title_short | The Role of microRNAs in the Cisplatin- and Radio-Resistance of Cervical Cancer |
| title_sort | role of micrornas in the cisplatin and radio resistance of cervical cancer |
| topic | cervical cancer cisplatin microRNA drug resistance radiotherapy cisplatin resistance |
| url | https://www.mdpi.com/2072-6694/13/5/1168 |
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