Serum autotaxin levels in responders to HCV treatment by direct-acting antivirals
Abstract Background Hepatitis C virus (HCV) infection is considered one of the main causes of chronic liver disease around the world. Liver biopsy has been believed to be the gold standard for the assessment of the degree of liver fibrosis. Thus, there is a need to improve non-invasive evaluation of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-08-01
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| Series: | Egyptian Liver Journal |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s43066-020-00051-x |
| _version_ | 1818109881594413056 |
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| author | Nancy Abdel Fattah Ahmed Ahmed Galal Deiab Ahmad Shawki Mohammad Hasan Ahmad Mohamed Yousry Abd Elbaky |
| author_facet | Nancy Abdel Fattah Ahmed Ahmed Galal Deiab Ahmad Shawki Mohammad Hasan Ahmad Mohamed Yousry Abd Elbaky |
| author_sort | Nancy Abdel Fattah Ahmed |
| collection | DOAJ |
| description | Abstract Background Hepatitis C virus (HCV) infection is considered one of the main causes of chronic liver disease around the world. Liver biopsy has been believed to be the gold standard for the assessment of the degree of liver fibrosis. Thus, there is a need to improve non-invasive evaluation of liver fibrosis. The aim of the present study was to study the changes in serum levels of ATX (Autotaxin) as a marker of hepatic fibrosis in responders to HCV treatment by DAAs. This prospective study was carried out at hepatology outpatient clinics for HCV treatment in Mansoura Specialized Medical Hospital that involved 54 participants: 34 patients with HCV and 20 controls; ATX was measured for the controls and all patients before and after treatment. Results We found a significant higher ATX level in control subjects vs HCV patients, 100% of control subjects had ATX > 97.5 and 58.8% of HCV had ATX ≤ 97.5. Also, a significantly higher ATX after treatment with DAAs as a whole was observed. Conclusion The authors concluded that ATX should be considered cautiously as a diagnostic marker for liver fibrosis in Egyptian patients with chronic hepatitis C infection. Although this study yielded negative results, this may be important to prevent duplication of the research efforts. |
| first_indexed | 2024-12-11T02:38:18Z |
| format | Article |
| id | doaj.art-af1356c1b6ba4453908b39ae750cfc05 |
| institution | Directory Open Access Journal |
| issn | 2090-6226 |
| language | English |
| last_indexed | 2024-12-11T02:38:18Z |
| publishDate | 2020-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Liver Journal |
| spelling | doaj.art-af1356c1b6ba4453908b39ae750cfc052022-12-22T01:23:40ZengSpringerOpenEgyptian Liver Journal2090-62262020-08-011011410.1186/s43066-020-00051-xSerum autotaxin levels in responders to HCV treatment by direct-acting antiviralsNancy Abdel Fattah Ahmed0Ahmed Galal Deiab1Ahmad Shawki Mohammad Hasan2Ahmad Mohamed Yousry Abd Elbaky3Internal Medicine Department, Hepatology & Gastroenterology Unit, Mansoura Specialized Medical Hospital, Mansoura University Faculty of MedicineInternal Medicine Department, Hepatology & Gastroenterology Unit, Mansoura Specialized Medical Hospital, Mansoura University Faculty of MedicineClinical Pathology Department, Mansoura University Faculty of MedicineMaster Second Candidate Internal Medicine, Sherbeen Hospital, Ministry of Health DakahliaAbstract Background Hepatitis C virus (HCV) infection is considered one of the main causes of chronic liver disease around the world. Liver biopsy has been believed to be the gold standard for the assessment of the degree of liver fibrosis. Thus, there is a need to improve non-invasive evaluation of liver fibrosis. The aim of the present study was to study the changes in serum levels of ATX (Autotaxin) as a marker of hepatic fibrosis in responders to HCV treatment by DAAs. This prospective study was carried out at hepatology outpatient clinics for HCV treatment in Mansoura Specialized Medical Hospital that involved 54 participants: 34 patients with HCV and 20 controls; ATX was measured for the controls and all patients before and after treatment. Results We found a significant higher ATX level in control subjects vs HCV patients, 100% of control subjects had ATX > 97.5 and 58.8% of HCV had ATX ≤ 97.5. Also, a significantly higher ATX after treatment with DAAs as a whole was observed. Conclusion The authors concluded that ATX should be considered cautiously as a diagnostic marker for liver fibrosis in Egyptian patients with chronic hepatitis C infection. Although this study yielded negative results, this may be important to prevent duplication of the research efforts.http://link.springer.com/article/10.1186/s43066-020-00051-xSerum autotaxinDirect-acting antiviralsHepatic fibrosis |
| spellingShingle | Nancy Abdel Fattah Ahmed Ahmed Galal Deiab Ahmad Shawki Mohammad Hasan Ahmad Mohamed Yousry Abd Elbaky Serum autotaxin levels in responders to HCV treatment by direct-acting antivirals Egyptian Liver Journal Serum autotaxin Direct-acting antivirals Hepatic fibrosis |
| title | Serum autotaxin levels in responders to HCV treatment by direct-acting antivirals |
| title_full | Serum autotaxin levels in responders to HCV treatment by direct-acting antivirals |
| title_fullStr | Serum autotaxin levels in responders to HCV treatment by direct-acting antivirals |
| title_full_unstemmed | Serum autotaxin levels in responders to HCV treatment by direct-acting antivirals |
| title_short | Serum autotaxin levels in responders to HCV treatment by direct-acting antivirals |
| title_sort | serum autotaxin levels in responders to hcv treatment by direct acting antivirals |
| topic | Serum autotaxin Direct-acting antivirals Hepatic fibrosis |
| url | http://link.springer.com/article/10.1186/s43066-020-00051-x |
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