EZH2 immunoexpression in pleomorphic adenoma and adenoid cystic carcinoma and clinicopathological features
Abstract The aim of this study was to evaluate the expression of the EZH2 protein and describe the clinical and microscopic characteristics of adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA). The study included 16 ACC cases and 12 PA. All ACC and PA cases were positive for EZH2 and the A...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Pesquisa Odontológica
2024-03-01
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| Series: | Brazilian Oral Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242024000109500&lng=en&tlng=en |
| _version_ | 1797265346359459840 |
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| author | Mariana Saturnino de NORONHA Karolina Skarlet Silva VIANA Maria Cássia Ferreira de AGUIAR Cristiane Helena SQUARIZE Mauro Henrique Nogueira Guimarães de ABREU Elismauro Francisco MENDONÇA Vanessa de Fátima BERNARDES |
| author_facet | Mariana Saturnino de NORONHA Karolina Skarlet Silva VIANA Maria Cássia Ferreira de AGUIAR Cristiane Helena SQUARIZE Mauro Henrique Nogueira Guimarães de ABREU Elismauro Francisco MENDONÇA Vanessa de Fátima BERNARDES |
| author_sort | Mariana Saturnino de NORONHA |
| collection | DOAJ |
| description | Abstract The aim of this study was to evaluate the expression of the EZH2 protein and describe the clinical and microscopic characteristics of adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA). The study included 16 ACC cases and 12 PA. All ACC and PA cases were positive for EZH2 and the ACC samples showed significantly higher EZH2 expression. The clinical and microscopic covariates were described in relation to EZH2 staining in ACC samples. The highest mean values of EZH2 were observed in cases with local metastasis, recurrence, perineural invasion, and predominantly cribriform growth pattern without solid areas. EZH2 is a potential marker of malignancy. |
| first_indexed | 2024-04-25T00:43:20Z |
| format | Article |
| id | doaj.art-af1b98e6c7fc48cba0dbdc550b285605 |
| institution | Directory Open Access Journal |
| issn | 1807-3107 |
| language | English |
| last_indexed | 2024-04-25T00:43:20Z |
| publishDate | 2024-03-01 |
| publisher | Sociedade Brasileira de Pesquisa Odontológica |
| record_format | Article |
| series | Brazilian Oral Research |
| spelling | doaj.art-af1b98e6c7fc48cba0dbdc550b2856052024-03-12T07:42:51ZengSociedade Brasileira de Pesquisa OdontológicaBrazilian Oral Research1807-31072024-03-013810.1590/1807-3107bor-2024.vol38.0018EZH2 immunoexpression in pleomorphic adenoma and adenoid cystic carcinoma and clinicopathological featuresMariana Saturnino de NORONHAhttps://orcid.org/0000-0001-9188-1939Karolina Skarlet Silva VIANAhttps://orcid.org/0000-0001-6467-1434Maria Cássia Ferreira de AGUIARhttps://orcid.org/0000-0001-5134-3466Cristiane Helena SQUARIZEhttps://orcid.org/0000-0002-6782-3429Mauro Henrique Nogueira Guimarães de ABREUhttps://orcid.org/0000-0001-8794-5725Elismauro Francisco MENDONÇAhttps://orcid.org/0000-0002-6751-3279Vanessa de Fátima BERNARDEShttps://orcid.org/0000-0003-0194-7434Abstract The aim of this study was to evaluate the expression of the EZH2 protein and describe the clinical and microscopic characteristics of adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA). The study included 16 ACC cases and 12 PA. All ACC and PA cases were positive for EZH2 and the ACC samples showed significantly higher EZH2 expression. The clinical and microscopic covariates were described in relation to EZH2 staining in ACC samples. The highest mean values of EZH2 were observed in cases with local metastasis, recurrence, perineural invasion, and predominantly cribriform growth pattern without solid areas. EZH2 is a potential marker of malignancy.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242024000109500&lng=en&tlng=enImmunohistochemistryEnhancer of Zeste Homolog 2 ProteinSalivary Gland NeoplasmsCarcinoma, Adenoid CysticAdenoma, Pleomorphic |
| spellingShingle | Mariana Saturnino de NORONHA Karolina Skarlet Silva VIANA Maria Cássia Ferreira de AGUIAR Cristiane Helena SQUARIZE Mauro Henrique Nogueira Guimarães de ABREU Elismauro Francisco MENDONÇA Vanessa de Fátima BERNARDES EZH2 immunoexpression in pleomorphic adenoma and adenoid cystic carcinoma and clinicopathological features Brazilian Oral Research Immunohistochemistry Enhancer of Zeste Homolog 2 Protein Salivary Gland Neoplasms Carcinoma, Adenoid Cystic Adenoma, Pleomorphic |
| title | EZH2 immunoexpression in pleomorphic adenoma and adenoid cystic carcinoma and clinicopathological features |
| title_full | EZH2 immunoexpression in pleomorphic adenoma and adenoid cystic carcinoma and clinicopathological features |
| title_fullStr | EZH2 immunoexpression in pleomorphic adenoma and adenoid cystic carcinoma and clinicopathological features |
| title_full_unstemmed | EZH2 immunoexpression in pleomorphic adenoma and adenoid cystic carcinoma and clinicopathological features |
| title_short | EZH2 immunoexpression in pleomorphic adenoma and adenoid cystic carcinoma and clinicopathological features |
| title_sort | ezh2 immunoexpression in pleomorphic adenoma and adenoid cystic carcinoma and clinicopathological features |
| topic | Immunohistochemistry Enhancer of Zeste Homolog 2 Protein Salivary Gland Neoplasms Carcinoma, Adenoid Cystic Adenoma, Pleomorphic |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242024000109500&lng=en&tlng=en |
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