Association of Angiotensin Converting Enzyme Gene Insertion / Deletion Polymorphism with Risk of Ischemic Heart Disease in A Population of Smokers in Southern India
Background: Ischemic heart disease (IHD) remains a major public health problem nationally and internationally. Smoking is a major risk factor for IHD.The deletion (D) allele of the angiotensin converting enzyme (ACE) gene polymorphism has been associated with hypertension, ischemic stroke and m...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2015-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/5852/12634_CE[Ra1]_F(AK)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
| _version_ | 1828427978097295360 |
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| author | Sandhya Metta Satyanarayana Uppala Doddamani R Basalingappa Srinivasa R Badeti Geeta Mitta Shruti Mohanty Subhadra Poornima Qurratulain Hasan |
| author_facet | Sandhya Metta Satyanarayana Uppala Doddamani R Basalingappa Srinivasa R Badeti Geeta Mitta Shruti Mohanty Subhadra Poornima Qurratulain Hasan |
| author_sort | Sandhya Metta |
| collection | DOAJ |
| description | Background: Ischemic heart disease (IHD) remains a major
public health problem nationally and internationally. Smoking
is a major risk factor for IHD.The deletion (D) allele of the
angiotensin converting enzyme (ACE) gene polymorphism
has been associated with hypertension, ischemic stroke and
myocardial infarction. The present study was carried out to
determine the association of the ACE gene insertion/deletion
(I/D) polymorphism in IHD patients with and without smoking.
Materials and Methods: One hundred seven male IHD patients
admitted consecutively in the Cardiology unit of a Government
Hospital and 100 age and sex matched healthy controls were
enrolled in this study.The patients were further divided into
smokers and nonsmokers. All the subjects were checked for
I/D polymorphism of ACE gene, which is mapped to 17q23.3
with OMIM no 106180, by polymerase chain reaction (PCR).
The subjects were also investigated for lipid profile and ejection
fraction (EF).
Results: We found significant difference in the distribution of D
allele between patients and controls (p=0.009, OR 1.69, 95%
CI 1.139 to 2.517).The significantly lower EF (p<0.001) was
suggestive of greater cardiovascular compromise in smokers.
The frequency of ID genotype was significantly associated
with cases compared to controls (p=0.012, OR 2.054, 95% CI
1.1694-3.624) but was not significantly associated with smokers
as compared to nonsmokers.
Conclusion: We infer significant association of D allele with IHD.
The smokers with ID genotype should be put on prophylactic
ACE inhibitor therapy to prevent the morbidity and mortality
associated with IHD. |
| first_indexed | 2024-12-10T17:11:01Z |
| format | Article |
| id | doaj.art-af1bbe958126445f8a617d3bf88097a8 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-10T17:11:01Z |
| publishDate | 2015-04-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-af1bbe958126445f8a617d3bf88097a82022-12-22T01:40:19ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-04-0194GC01GC0410.7860/JCDR/2015/12634.5852Association of Angiotensin Converting Enzyme Gene Insertion / Deletion Polymorphism with Risk of Ischemic Heart Disease in A Population of Smokers in Southern IndiaSandhya Metta0Satyanarayana Uppala1Doddamani R Basalingappa2Srinivasa R Badeti3Geeta Mitta4Shruti Mohanty5Subhadra Poornima6Qurratulain Hasan7PhD Scholar, Department of Physiology, Gandhi Medical College, Secunderabad, Telangana, India.Professor, Department of Biochemistry, Dr Pinnamaneni Sidhartha Institute of Medical Sciences and Research Foundation, Gannavaram, Vijayawada, Andhra Pradesh, India.Professor and Head, Department of Physiology, Kamineni Institute of Medical Sciences, Narketpally, Nalgonda, Telangana, India.Professor and Head, Department of Physiology, Gandhi Medical College, Secunderabad, Telangana, India.Professor, Department of Physiology, Gandhi Medical College, Secunderabad, Telangana, India.Professor and Head, Department of Biochemistry, Kamineni Institute of Medical Sciences, Narketpally, Nalgonda, Telangana, India.Senior Geneticist, Kamineni Hospitals, LB Nagar, Hyderabad, Telangana, India.Professor and Head, Department of Genetics and Molecular Medicine, Kamineni Academy of Medical Sciences and Research Center, LB Nagar, Hyderabad, Telangana, India. Background: Ischemic heart disease (IHD) remains a major public health problem nationally and internationally. Smoking is a major risk factor for IHD.The deletion (D) allele of the angiotensin converting enzyme (ACE) gene polymorphism has been associated with hypertension, ischemic stroke and myocardial infarction. The present study was carried out to determine the association of the ACE gene insertion/deletion (I/D) polymorphism in IHD patients with and without smoking. Materials and Methods: One hundred seven male IHD patients admitted consecutively in the Cardiology unit of a Government Hospital and 100 age and sex matched healthy controls were enrolled in this study.The patients were further divided into smokers and nonsmokers. All the subjects were checked for I/D polymorphism of ACE gene, which is mapped to 17q23.3 with OMIM no 106180, by polymerase chain reaction (PCR). The subjects were also investigated for lipid profile and ejection fraction (EF). Results: We found significant difference in the distribution of D allele between patients and controls (p=0.009, OR 1.69, 95% CI 1.139 to 2.517).The significantly lower EF (p<0.001) was suggestive of greater cardiovascular compromise in smokers. The frequency of ID genotype was significantly associated with cases compared to controls (p=0.012, OR 2.054, 95% CI 1.1694-3.624) but was not significantly associated with smokers as compared to nonsmokers. Conclusion: We infer significant association of D allele with IHD. The smokers with ID genotype should be put on prophylactic ACE inhibitor therapy to prevent the morbidity and mortality associated with IHD.https://jcdr.net/articles/PDF/5852/12634_CE[Ra1]_F(AK)_PF1(PAK)_PFA(AK)_PF2(PAG).pdfgene polymorphismsmoking |
| spellingShingle | Sandhya Metta Satyanarayana Uppala Doddamani R Basalingappa Srinivasa R Badeti Geeta Mitta Shruti Mohanty Subhadra Poornima Qurratulain Hasan Association of Angiotensin Converting Enzyme Gene Insertion / Deletion Polymorphism with Risk of Ischemic Heart Disease in A Population of Smokers in Southern India Journal of Clinical and Diagnostic Research gene polymorphism smoking |
| title | Association of Angiotensin Converting Enzyme Gene Insertion / Deletion Polymorphism with Risk of Ischemic Heart Disease in A Population of Smokers in Southern India |
| title_full | Association of Angiotensin Converting Enzyme Gene Insertion / Deletion Polymorphism with Risk of Ischemic Heart Disease in A Population of Smokers in Southern India |
| title_fullStr | Association of Angiotensin Converting Enzyme Gene Insertion / Deletion Polymorphism with Risk of Ischemic Heart Disease in A Population of Smokers in Southern India |
| title_full_unstemmed | Association of Angiotensin Converting Enzyme Gene Insertion / Deletion Polymorphism with Risk of Ischemic Heart Disease in A Population of Smokers in Southern India |
| title_short | Association of Angiotensin Converting Enzyme Gene Insertion / Deletion Polymorphism with Risk of Ischemic Heart Disease in A Population of Smokers in Southern India |
| title_sort | association of angiotensin converting enzyme gene insertion deletion polymorphism with risk of ischemic heart disease in a population of smokers in southern india |
| topic | gene polymorphism smoking |
| url | https://jcdr.net/articles/PDF/5852/12634_CE[Ra1]_F(AK)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
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