Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity

Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity

Disease-mediated alterations to drug disposition constitute a significant source of adverse drug reactions. Cisplatin (CDDP) elicits nephrotoxicity due to exposure in proximal tubule cells during renal secretion. Alterations to renal drug transporter expression have been discovered during nonalcohol...

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Bibliographic Details
Main Authors: Joseph L. Jilek, Kayla L. Frost, Kevyn A. Jacobus, Wenxi He, Erica L. Toth, Michael Goedken, Nathan J. Cherrington
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Nonalcoholic steatohepatitis
NASH
Cisplatin
Drug transporter
Nephrotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521002100

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