Impaired mRNA splicing and proteostasis in preadipocytes in obesity-related metabolic disease

Impaired mRNA splicing and proteostasis in preadipocytes in obesity-related metabolic disease

Preadipocytes are crucial for healthy adipose tissue expansion. Preadipocyte differentiation is altered in obese individuals, which has been proposed to contribute to obesity-associated metabolic disturbances. Here, we aimed at identifying the pathogenic processes underlying impaired adipocyte diffe...

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Bibliografske podrobnosti
Main Authors: Julia Sánchez-Ceinos, Rocío Guzmán-Ruiz, Oriol Alberto Rangel-Zúñiga, Jaime López-Alcalá, Elena Moreno-Caño, Mercedes Del Río-Moreno, Juan Luis Romero-Cabrera, Pablo Pérez-Martínez, Elsa Maymo-Masip, Joan Vendrell, Sonia Fernández-Veledo, José Manuel Fernández-Real, Jurga Laurencikiene, Mikael Rydén, Antonio Membrives, Raul M Luque, José López-Miranda, María M Malagón
Format: Article
Jezik:English
Izdano: eLife Sciences Publications Ltd 2021-09-01
Serija:eLife
Teme:
preadipocytes
obesity-related metabolic diseases
RNA splicing
ER-proteostasis
UPR
ERAD
Online dostop:https://elifesciences.org/articles/65996

Internet

https://elifesciences.org/articles/65996

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