The Diverse Roles of TAO Kinases in Health and Diseases
Thousand and one kinases (TAOKs) are members of the MAP kinase kinase kinase (MAP3K) family. Three members of this subfamily, TAOK1, 2, and 3, have been identified in mammals. It has been shown that TAOK1, 2 and 3 regulate the p38 MAPK and Hippo signaling pathways, while TAOK 1 and 2 modulate the SA...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-10-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/20/7463 |
| _version_ | 1797551432387264512 |
|---|---|
| author | Chih-Yeu Fang Tsung-Ching Lai Michael Hsiao Yu-Chan Chang |
| author_facet | Chih-Yeu Fang Tsung-Ching Lai Michael Hsiao Yu-Chan Chang |
| author_sort | Chih-Yeu Fang |
| collection | DOAJ |
| description | Thousand and one kinases (TAOKs) are members of the MAP kinase kinase kinase (MAP3K) family. Three members of this subfamily, TAOK1, 2, and 3, have been identified in mammals. It has been shown that TAOK1, 2 and 3 regulate the p38 MAPK and Hippo signaling pathways, while TAOK 1 and 2 modulate the SAPK/JNK cascade. Furthermore, TAOKs are involved in additional interactions with other cellular proteins and all of these pathways modulate vital physiological and pathophysiological responses in cells and tissues. Dysregulation of TAOK-related pathways is implicated in the development of diseases including inflammatory and immune disorders, cancer and drug resistance, and autism and Alzheimer’s diseases. This review collates current knowledge concerning the roles of TAOKs in protein–protein interaction, signal transduction, physiological regulation, and pathogenesis and summarizes the recent development of TAOK-specific inhibitors that have the potential to ameliorate TAOKs’ effects in pathological situations. |
| first_indexed | 2024-03-10T15:44:38Z |
| format | Article |
| id | doaj.art-af2277dc58c642b2b0e96fe6cd06ace0 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:44:38Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-af2277dc58c642b2b0e96fe6cd06ace02023-11-20T16:32:56ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-012120746310.3390/ijms21207463The Diverse Roles of TAO Kinases in Health and DiseasesChih-Yeu Fang0Tsung-Ching Lai1Michael Hsiao2Yu-Chan Chang3Genomics Research Center, Academia Sinica, Taipei 115, TaiwanDivision of Pulmonary Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 116, TaiwanGenomics Research Center, Academia Sinica, Taipei 115, TaiwanDepartment of Biomedical Imaging and Radiological Science, National Yang-Ming University, Taipei 112, TaiwanThousand and one kinases (TAOKs) are members of the MAP kinase kinase kinase (MAP3K) family. Three members of this subfamily, TAOK1, 2, and 3, have been identified in mammals. It has been shown that TAOK1, 2 and 3 regulate the p38 MAPK and Hippo signaling pathways, while TAOK 1 and 2 modulate the SAPK/JNK cascade. Furthermore, TAOKs are involved in additional interactions with other cellular proteins and all of these pathways modulate vital physiological and pathophysiological responses in cells and tissues. Dysregulation of TAOK-related pathways is implicated in the development of diseases including inflammatory and immune disorders, cancer and drug resistance, and autism and Alzheimer’s diseases. This review collates current knowledge concerning the roles of TAOKs in protein–protein interaction, signal transduction, physiological regulation, and pathogenesis and summarizes the recent development of TAOK-specific inhibitors that have the potential to ameliorate TAOKs’ effects in pathological situations.https://www.mdpi.com/1422-0067/21/20/7463thousand and one kinasep38 MAPKSAPK/JNKHippoTAOK |
| spellingShingle | Chih-Yeu Fang Tsung-Ching Lai Michael Hsiao Yu-Chan Chang The Diverse Roles of TAO Kinases in Health and Diseases International Journal of Molecular Sciences thousand and one kinase p38 MAPK SAPK/JNK Hippo TAOK |
| title | The Diverse Roles of TAO Kinases in Health and Diseases |
| title_full | The Diverse Roles of TAO Kinases in Health and Diseases |
| title_fullStr | The Diverse Roles of TAO Kinases in Health and Diseases |
| title_full_unstemmed | The Diverse Roles of TAO Kinases in Health and Diseases |
| title_short | The Diverse Roles of TAO Kinases in Health and Diseases |
| title_sort | diverse roles of tao kinases in health and diseases |
| topic | thousand and one kinase p38 MAPK SAPK/JNK Hippo TAOK |
| url | https://www.mdpi.com/1422-0067/21/20/7463 |
| work_keys_str_mv | AT chihyeufang thediverserolesoftaokinasesinhealthanddiseases AT tsungchinglai thediverserolesoftaokinasesinhealthanddiseases AT michaelhsiao thediverserolesoftaokinasesinhealthanddiseases AT yuchanchang thediverserolesoftaokinasesinhealthanddiseases AT chihyeufang diverserolesoftaokinasesinhealthanddiseases AT tsungchinglai diverserolesoftaokinasesinhealthanddiseases AT michaelhsiao diverserolesoftaokinasesinhealthanddiseases AT yuchanchang diverserolesoftaokinasesinhealthanddiseases |