Honokiol in glioblastoma recurrence: a case report
Glioblastoma is the most common and aggressive primary tumor in the central nervous system. There is no standard of care for patients with recurrent GBM. Honokiol is a pleiotropic lignan and has the potential to be a potent and safe anticancer agent in human GBM when it is encapsulated by liposomes....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1172860/full |
| _version_ | 1797797754256228352 |
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| author | Ce Wang Zehao Cai Yue Huang Xinrui Liu Xing Liu Feng Chen Wenbin Li |
| author_facet | Ce Wang Zehao Cai Yue Huang Xinrui Liu Xing Liu Feng Chen Wenbin Li |
| author_sort | Ce Wang |
| collection | DOAJ |
| description | Glioblastoma is the most common and aggressive primary tumor in the central nervous system. There is no standard of care for patients with recurrent GBM. Honokiol is a pleiotropic lignan and has the potential to be a potent and safe anticancer agent in human GBM when it is encapsulated by liposomes. We report an efficient and safe response to three phases of treatment with liposomal honokiol in a patient with recurrent glioblastoma. |
| first_indexed | 2024-03-13T03:53:08Z |
| format | Article |
| id | doaj.art-af23b1855a4d469e99215eb9d11c0321 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-13T03:53:08Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-af23b1855a4d469e99215eb9d11c03212023-06-22T09:29:47ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-06-011410.3389/fneur.2023.11728601172860Honokiol in glioblastoma recurrence: a case reportCe Wang0Zehao Cai1Yue Huang2Xinrui Liu3Xing Liu4Feng Chen5Wenbin Li6Department of Neuro-Oncology, Cancer Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neuro-Oncology, Cancer Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaHuman Brain and Tissue Bank, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neuro-Oncology, Cancer Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neuropathology, Beijing Neurosurgical Institute, Beijing, ChinaDepartment of Neuro-Oncology, Cancer Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neuro-Oncology, Cancer Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaGlioblastoma is the most common and aggressive primary tumor in the central nervous system. There is no standard of care for patients with recurrent GBM. Honokiol is a pleiotropic lignan and has the potential to be a potent and safe anticancer agent in human GBM when it is encapsulated by liposomes. We report an efficient and safe response to three phases of treatment with liposomal honokiol in a patient with recurrent glioblastoma.https://www.frontiersin.org/articles/10.3389/fneur.2023.1172860/fullglioblastomaliposomal honokiolblood–brain barrier permeabilityclinical trialtumor progression |
| spellingShingle | Ce Wang Zehao Cai Yue Huang Xinrui Liu Xing Liu Feng Chen Wenbin Li Honokiol in glioblastoma recurrence: a case report Frontiers in Neurology glioblastoma liposomal honokiol blood–brain barrier permeability clinical trial tumor progression |
| title | Honokiol in glioblastoma recurrence: a case report |
| title_full | Honokiol in glioblastoma recurrence: a case report |
| title_fullStr | Honokiol in glioblastoma recurrence: a case report |
| title_full_unstemmed | Honokiol in glioblastoma recurrence: a case report |
| title_short | Honokiol in glioblastoma recurrence: a case report |
| title_sort | honokiol in glioblastoma recurrence a case report |
| topic | glioblastoma liposomal honokiol blood–brain barrier permeability clinical trial tumor progression |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1172860/full |
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