Identification of BRCC3 and BRCA1 as Regulators of TAZ Stability and Activity

Identification of BRCC3 and BRCA1 as Regulators of TAZ Stability and Activity

TAZ (WWTR1) is a transcriptional co-activator regulated by Hippo signaling, mechano-transduction, and G-protein couple receptors. Once activated, TAZ and its paralogue, YAP1, regulate gene expression programs promoting cell proliferation, survival, and differentiation, thus controlling embryonic dev...

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Bibliographic Details
Main Authors: Silvia Sberna, Alejandro Lopez-Hernandez, Chiara Biancotto, Luca Motta, Adrian Andronache, Lisette G. G. C. Verhoef, Marieta Caganova, Stefano Campaner
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cells
Subjects:
YAP1
TAZ
WWTR1
BRCC3
BRCA1
post-translational regulation
Online Access:https://www.mdpi.com/2073-4409/12/20/2431

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