Effectiveness of gastrodin for migraine: A meta-analysis
BackgroundGastrodia elata Blume (GEB), a traditional Chinese medicine, has been widely used to treat dizziness, numbness of limbs, and infantile convulsion, among other issues. Gastrodin is the main component of GEB. This meta-analysis aimed to evaluate the efficacy and safety of gastrodin in the tr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.939401/full |
| _version_ | 1818513907826819072 |
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| author | Xiu Zhou Jingyi Shao Xiuzhen Xie Yingqi Xu Tianyu Shao Zhuqing Jin |
| author_facet | Xiu Zhou Jingyi Shao Xiuzhen Xie Yingqi Xu Tianyu Shao Zhuqing Jin |
| author_sort | Xiu Zhou |
| collection | DOAJ |
| description | BackgroundGastrodia elata Blume (GEB), a traditional Chinese medicine, has been widely used to treat dizziness, numbness of limbs, and infantile convulsion, among other issues. Gastrodin is the main component of GEB. This meta-analysis aimed to evaluate the efficacy and safety of gastrodin in the treatment of migraine.MethodsTen electronic databases, namely the Cochrane Library, Embase, EBSCO, PubMed, Web of Science, CENTRAL, CNKI (China National Knowledge Infrastructure), CBM (Chinese Biomedicine Database), WanFang, and VIP (Chinese Scientific Journals Database), were searched for randomized controlled trials (RCTs) of gastrodin for migraine published before September 2021. The data were analyzed by RevMan 5.3 software and evaluated by GRADEpro.ResultsA total of 1,332 subjects were included in 16 RCTs. The meta-analysis showed that gastrodin was significantly effective in treating migraine (RR = 1.21, 95%CI = [1.17, 1.27]), reducing the pain degree (MD = −1.65, 95% CI = [−2.28, −1.02]), reducing the frequency of migraine attack (SMD = −2.77, 95% CI = [−3.92, −1.62]), shortening the duration of migraine attack (SMD = −1.64, 95% CI = [−2.35, −0.93]), and slowing average arterial cerebral blood flow velocity (SMD = −3.19, 95% CI = [−5.21, −1.17]), as well as being safe.ConclusionsThis systematic review revealed gastrodin is effective and safe in the treatment of migraine.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=197094, identifier: CRD42020197094. |
| first_indexed | 2024-12-11T00:08:03Z |
| format | Article |
| id | doaj.art-af2444c110c84453aec4413ba81c86b2 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-11T00:08:03Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-af2444c110c84453aec4413ba81c86b22022-12-22T01:28:16ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-08-011310.3389/fneur.2022.939401939401Effectiveness of gastrodin for migraine: A meta-analysisXiu Zhou0Jingyi Shao1Xiuzhen Xie2Yingqi Xu3Tianyu Shao4Zhuqing Jin5The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, ChinaDongzhimen Hospital Beijing University of Chinese Medical, Beijing, ChinaThe Third School of Clinical Medicine (School of Rehabilitation Medicine), Hangzhou, ChinaThe Third School of Clinical Medicine (School of Rehabilitation Medicine), Hangzhou, ChinaThe First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, ChinaBackgroundGastrodia elata Blume (GEB), a traditional Chinese medicine, has been widely used to treat dizziness, numbness of limbs, and infantile convulsion, among other issues. Gastrodin is the main component of GEB. This meta-analysis aimed to evaluate the efficacy and safety of gastrodin in the treatment of migraine.MethodsTen electronic databases, namely the Cochrane Library, Embase, EBSCO, PubMed, Web of Science, CENTRAL, CNKI (China National Knowledge Infrastructure), CBM (Chinese Biomedicine Database), WanFang, and VIP (Chinese Scientific Journals Database), were searched for randomized controlled trials (RCTs) of gastrodin for migraine published before September 2021. The data were analyzed by RevMan 5.3 software and evaluated by GRADEpro.ResultsA total of 1,332 subjects were included in 16 RCTs. The meta-analysis showed that gastrodin was significantly effective in treating migraine (RR = 1.21, 95%CI = [1.17, 1.27]), reducing the pain degree (MD = −1.65, 95% CI = [−2.28, −1.02]), reducing the frequency of migraine attack (SMD = −2.77, 95% CI = [−3.92, −1.62]), shortening the duration of migraine attack (SMD = −1.64, 95% CI = [−2.35, −0.93]), and slowing average arterial cerebral blood flow velocity (SMD = −3.19, 95% CI = [−5.21, −1.17]), as well as being safe.ConclusionsThis systematic review revealed gastrodin is effective and safe in the treatment of migraine.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=197094, identifier: CRD42020197094.https://www.frontiersin.org/articles/10.3389/fneur.2022.939401/fullgastrodinmigrainerandomized controlled trialmeta-analysisclinical efficacy |
| spellingShingle | Xiu Zhou Jingyi Shao Xiuzhen Xie Yingqi Xu Tianyu Shao Zhuqing Jin Effectiveness of gastrodin for migraine: A meta-analysis Frontiers in Neurology gastrodin migraine randomized controlled trial meta-analysis clinical efficacy |
| title | Effectiveness of gastrodin for migraine: A meta-analysis |
| title_full | Effectiveness of gastrodin for migraine: A meta-analysis |
| title_fullStr | Effectiveness of gastrodin for migraine: A meta-analysis |
| title_full_unstemmed | Effectiveness of gastrodin for migraine: A meta-analysis |
| title_short | Effectiveness of gastrodin for migraine: A meta-analysis |
| title_sort | effectiveness of gastrodin for migraine a meta analysis |
| topic | gastrodin migraine randomized controlled trial meta-analysis clinical efficacy |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.939401/full |
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