New insights on the cardiovascular effects of IGF-1
IntroductionCardiovascular (CV) disorders are steadily increasing, making them the world’s most prevalent health issue. New research highlights the importance of insulin-like growth factor 1 (IGF-1) for maintaining CV healthMethodsWe searched PubMed and MEDLINE for English and non-English articles w...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-02-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1142644/full |
| _version_ | 1811168422941163520 |
|---|---|
| author | Mirjana Macvanin Zoran Gluvic Jelena Radovanovic Magbubah Essack Magbubah Essack Xin Gao Xin Gao Esma R. Isenovic |
| author_facet | Mirjana Macvanin Zoran Gluvic Jelena Radovanovic Magbubah Essack Magbubah Essack Xin Gao Xin Gao Esma R. Isenovic |
| author_sort | Mirjana Macvanin |
| collection | DOAJ |
| description | IntroductionCardiovascular (CV) disorders are steadily increasing, making them the world’s most prevalent health issue. New research highlights the importance of insulin-like growth factor 1 (IGF-1) for maintaining CV healthMethodsWe searched PubMed and MEDLINE for English and non-English articles with English abstracts published between 1957 (when the first report on IGF-1 identification was published) and 2022. The top search terms were: IGF-1, cardiovascular disease, IGF-1 receptors, IGF-1 and microRNAs, therapeutic interventions with IGF-1, IGF-1 and diabetes, IGF-1 and cardiovascular disease. The search retrieved original peer-reviewed articles, which were further analyzed, focusing on the role of IGF-1 in pathophysiological conditions. We specifically focused on including the most recent findings published in the past five years.ResultsIGF-1, an anabolic growth factor, regulates cell division, proliferation, and survival. In addition to its well-known growth-promoting and metabolic effects, there is mounting evidence that IGF-1 plays a specialized role in the complex activities that underpin CV function. IGF-1 promotes cardiac development and improves cardiac output, stroke volume, contractility, and ejection fraction. Furthermore, IGF-1 mediates many growth hormones (GH) actions. IGF-1 stimulates contractility and tissue remodeling in humans to improve heart function after myocardial infarction. IGF-1 also improves the lipid profile, lowers insulin levels, increases insulin sensitivity, and promotes glucose metabolism. These findings point to the intriguing medicinal potential of IGF-1. Human studies associate low serum levels of free or total IGF-1 with an increased risk of CV and cerebrovascular illness. Extensive human trials are being conducted to investigate the therapeutic efficacy and outcomes of IGF-1-related therapy.DiscussionWe anticipate the development of novel IGF-1-related therapy with minimal side effects. This review discusses recent findings on the role of IGF-1 in the cardiovascular (CVD) system, including both normal and pathological conditions. We also discuss progress in therapeutic interventions aimed at targeting the IGF axis and provide insights into the epigenetic regulation of IGF-1 mediated by microRNAs. |
| first_indexed | 2024-04-10T16:26:05Z |
| format | Article |
| id | doaj.art-af247a717b384c4a9fb24920ea2b0c12 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T16:26:05Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-af247a717b384c4a9fb24920ea2b0c122023-02-09T05:13:27ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-02-011410.3389/fendo.2023.11426441142644New insights on the cardiovascular effects of IGF-1Mirjana Macvanin0Zoran Gluvic1Jelena Radovanovic2Magbubah Essack3Magbubah Essack4Xin Gao5Xin Gao6Esma R. Isenovic7Department of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, SerbiaClinic for Internal Medicine, Department of Endocrinology and Diabetes, Zemun Clinical Hospital, School of Medicine, University of Belgrade, Belgrade, SerbiaDepartment of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, SerbiaComputational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi ArabiaComputer Science Program, Computer, Electrical and Mathematical Sciences and Engineering Division (CEMSE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi ArabiaComputational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi ArabiaComputer Science Program, Computer, Electrical and Mathematical Sciences and Engineering Division (CEMSE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi ArabiaDepartment of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, SerbiaIntroductionCardiovascular (CV) disorders are steadily increasing, making them the world’s most prevalent health issue. New research highlights the importance of insulin-like growth factor 1 (IGF-1) for maintaining CV healthMethodsWe searched PubMed and MEDLINE for English and non-English articles with English abstracts published between 1957 (when the first report on IGF-1 identification was published) and 2022. The top search terms were: IGF-1, cardiovascular disease, IGF-1 receptors, IGF-1 and microRNAs, therapeutic interventions with IGF-1, IGF-1 and diabetes, IGF-1 and cardiovascular disease. The search retrieved original peer-reviewed articles, which were further analyzed, focusing on the role of IGF-1 in pathophysiological conditions. We specifically focused on including the most recent findings published in the past five years.ResultsIGF-1, an anabolic growth factor, regulates cell division, proliferation, and survival. In addition to its well-known growth-promoting and metabolic effects, there is mounting evidence that IGF-1 plays a specialized role in the complex activities that underpin CV function. IGF-1 promotes cardiac development and improves cardiac output, stroke volume, contractility, and ejection fraction. Furthermore, IGF-1 mediates many growth hormones (GH) actions. IGF-1 stimulates contractility and tissue remodeling in humans to improve heart function after myocardial infarction. IGF-1 also improves the lipid profile, lowers insulin levels, increases insulin sensitivity, and promotes glucose metabolism. These findings point to the intriguing medicinal potential of IGF-1. Human studies associate low serum levels of free or total IGF-1 with an increased risk of CV and cerebrovascular illness. Extensive human trials are being conducted to investigate the therapeutic efficacy and outcomes of IGF-1-related therapy.DiscussionWe anticipate the development of novel IGF-1-related therapy with minimal side effects. This review discusses recent findings on the role of IGF-1 in the cardiovascular (CVD) system, including both normal and pathological conditions. We also discuss progress in therapeutic interventions aimed at targeting the IGF axis and provide insights into the epigenetic regulation of IGF-1 mediated by microRNAs.https://www.frontiersin.org/articles/10.3389/fendo.2023.1142644/fullIGF-1cardiovascular diseasesIGF-1 systematherosclerosisdiabetesmicroRNA |
| spellingShingle | Mirjana Macvanin Zoran Gluvic Jelena Radovanovic Magbubah Essack Magbubah Essack Xin Gao Xin Gao Esma R. Isenovic New insights on the cardiovascular effects of IGF-1 Frontiers in Endocrinology IGF-1 cardiovascular diseases IGF-1 system atherosclerosis diabetes microRNA |
| title | New insights on the cardiovascular effects of IGF-1 |
| title_full | New insights on the cardiovascular effects of IGF-1 |
| title_fullStr | New insights on the cardiovascular effects of IGF-1 |
| title_full_unstemmed | New insights on the cardiovascular effects of IGF-1 |
| title_short | New insights on the cardiovascular effects of IGF-1 |
| title_sort | new insights on the cardiovascular effects of igf 1 |
| topic | IGF-1 cardiovascular diseases IGF-1 system atherosclerosis diabetes microRNA |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1142644/full |
| work_keys_str_mv | AT mirjanamacvanin newinsightsonthecardiovasculareffectsofigf1 AT zorangluvic newinsightsonthecardiovasculareffectsofigf1 AT jelenaradovanovic newinsightsonthecardiovasculareffectsofigf1 AT magbubahessack newinsightsonthecardiovasculareffectsofigf1 AT magbubahessack newinsightsonthecardiovasculareffectsofigf1 AT xingao newinsightsonthecardiovasculareffectsofigf1 AT xingao newinsightsonthecardiovasculareffectsofigf1 AT esmarisenovic newinsightsonthecardiovasculareffectsofigf1 |