Sun-Exposed versus Sun-Protected Cutaneous Basal Cell Carcinoma: Clinico-Pathological Profile and p16 Immunostaining
Introduction: Although widespread, BCC is still relatively poorly understood in regards to pathogenesis and prognosis, particularly the lesions formed on anatomical sites away from sun exposure. With the aim of deepening our understanding of the pathogenesis and clinico-pathological correlations of...
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MDPI AG
2023-03-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/7/1271 |
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| author | Abdulkarim Hasan Ahmad M. Kandil Hasan S. Al-Ghamdi Mohammad A. Alghamdi Mohamed Nasr Suhaib Alsayed Naeem Wagih M. Abd-Elhay Osama Khalil E. Mohamed Hany Sabry A. Ibrahim Eman Mohamed Ahmed Ahmed Elsayed M. Abdrabo Shimaa Abdelraouf Elgohary |
| author_facet | Abdulkarim Hasan Ahmad M. Kandil Hasan S. Al-Ghamdi Mohammad A. Alghamdi Mohamed Nasr Suhaib Alsayed Naeem Wagih M. Abd-Elhay Osama Khalil E. Mohamed Hany Sabry A. Ibrahim Eman Mohamed Ahmed Ahmed Elsayed M. Abdrabo Shimaa Abdelraouf Elgohary |
| author_sort | Abdulkarim Hasan |
| collection | DOAJ |
| description | Introduction: Although widespread, BCC is still relatively poorly understood in regards to pathogenesis and prognosis, particularly the lesions formed on anatomical sites away from sun exposure. With the aim of deepening our understanding of the pathogenesis and clinico-pathological correlations of BCCs, we conducted this study. Methods: Tissue blocks and data of 52 Egyptian patients diagnosed with BCC were retrieved for clinical information and inclusion criteria, then re-examined histologically; p16 immunostaining was carried out and evaluated for analysis and comparison between the two groups, i.e., sun-exposed and sun-protected. Results: Sex, age, clinical suspicion, tumor size, recurrence status, and histologic variants did not show a significant difference between the sun-protected and sun-exposed groups; however, the mean ages recorded were 67.2 vs. 62.7 for the sun-protected and sun-exposed groups, respectively. A total of 52% of BCCs were positive for p16. The sun-protected lesions showed p16 positivity in 61% of cases, whereas 49% of the sun-exposed lesions were positive with no significant difference. There was a significant difference in p16 expression between the recurrent and non-recurrent lesions. Conclusions: A significant difference was seen in the case of cancer recurrence, where all the recurrent BCCs in this study demonstrated negative p16 immunostaining of the primary lesions; however, the positively stained cases in total were 52% of BCCs. The mean patient age of the sun-protected group was much higher than in previous peer studies. We assume that the biological, prognostic, and clinical aspects of p16 protein expression in BCCs are still far from being clearly understood. Further studies are highly recommended, with more focus on its role in the pathogenesis and the prognostic factors. |
| first_indexed | 2024-03-11T05:40:07Z |
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| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T05:40:07Z |
| publishDate | 2023-03-01 |
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| series | Diagnostics |
| spelling | doaj.art-af24ea36bf5640bbbfafc62631090ea12023-11-17T16:30:15ZengMDPI AGDiagnostics2075-44182023-03-01137127110.3390/diagnostics13071271Sun-Exposed versus Sun-Protected Cutaneous Basal Cell Carcinoma: Clinico-Pathological Profile and p16 ImmunostainingAbdulkarim Hasan0Ahmad M. Kandil1Hasan S. Al-Ghamdi2Mohammad A. Alghamdi3Mohamed Nasr4Suhaib Alsayed Naeem5Wagih M. Abd-Elhay6Osama Khalil E. Mohamed7Hany Sabry A. Ibrahim8Eman Mohamed Ahmed9Ahmed Elsayed M. Abdrabo10Shimaa Abdelraouf Elgohary11Pathology Department, Faculty of Medicine, Al-Azhar University, Cairo 11884, EgyptPathology Department, Faculty of Medicine, Al-Azhar University, Cairo 11884, EgyptInternal Medicine Department, Division of Dermatology, Faculty of Medicine, Albaha University, Albaha 65799, Saudi ArabiaInternal Medicine Department, Division of Dermatology, Faculty of Medicine, Albaha University, Albaha 65799, Saudi ArabiaHistology Department, Faculty of Medicine, Al-Azhar University, Cairo 11884, EgyptHistology Department, Faculty of Medicine, Al-Azhar University, Cairo 11884, EgyptHistology Department, Faculty of Medicine, Al-Azhar University, Cairo 11884, EgyptDermatology, Venerology and Andrology Department, Faculty of Medicine, Al-Azhar University, Cairo 11884, EgyptDermatology, Venerology and Andrology Department, International Islamic Center of Population Studies and Research, Al-Azhar University, Cairo 11651, EgyptPathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo 11884, EgyptCommunity and Industrial Medicine Department, Faculty of Medicine, Al-Azhar University, Cairo 11884, EgyptPathology Department, Faculty of Medicine, Ain Shams University, Cairo 11517, EgyptIntroduction: Although widespread, BCC is still relatively poorly understood in regards to pathogenesis and prognosis, particularly the lesions formed on anatomical sites away from sun exposure. With the aim of deepening our understanding of the pathogenesis and clinico-pathological correlations of BCCs, we conducted this study. Methods: Tissue blocks and data of 52 Egyptian patients diagnosed with BCC were retrieved for clinical information and inclusion criteria, then re-examined histologically; p16 immunostaining was carried out and evaluated for analysis and comparison between the two groups, i.e., sun-exposed and sun-protected. Results: Sex, age, clinical suspicion, tumor size, recurrence status, and histologic variants did not show a significant difference between the sun-protected and sun-exposed groups; however, the mean ages recorded were 67.2 vs. 62.7 for the sun-protected and sun-exposed groups, respectively. A total of 52% of BCCs were positive for p16. The sun-protected lesions showed p16 positivity in 61% of cases, whereas 49% of the sun-exposed lesions were positive with no significant difference. There was a significant difference in p16 expression between the recurrent and non-recurrent lesions. Conclusions: A significant difference was seen in the case of cancer recurrence, where all the recurrent BCCs in this study demonstrated negative p16 immunostaining of the primary lesions; however, the positively stained cases in total were 52% of BCCs. The mean patient age of the sun-protected group was much higher than in previous peer studies. We assume that the biological, prognostic, and clinical aspects of p16 protein expression in BCCs are still far from being clearly understood. Further studies are highly recommended, with more focus on its role in the pathogenesis and the prognostic factors.https://www.mdpi.com/2075-4418/13/7/1271basal cell carcinomaimmunohistochemistrynon-melanomcyticp16skin cancer |
| spellingShingle | Abdulkarim Hasan Ahmad M. Kandil Hasan S. Al-Ghamdi Mohammad A. Alghamdi Mohamed Nasr Suhaib Alsayed Naeem Wagih M. Abd-Elhay Osama Khalil E. Mohamed Hany Sabry A. Ibrahim Eman Mohamed Ahmed Ahmed Elsayed M. Abdrabo Shimaa Abdelraouf Elgohary Sun-Exposed versus Sun-Protected Cutaneous Basal Cell Carcinoma: Clinico-Pathological Profile and p16 Immunostaining Diagnostics basal cell carcinoma immunohistochemistry non-melanomcytic p16 skin cancer |
| title | Sun-Exposed versus Sun-Protected Cutaneous Basal Cell Carcinoma: Clinico-Pathological Profile and p16 Immunostaining |
| title_full | Sun-Exposed versus Sun-Protected Cutaneous Basal Cell Carcinoma: Clinico-Pathological Profile and p16 Immunostaining |
| title_fullStr | Sun-Exposed versus Sun-Protected Cutaneous Basal Cell Carcinoma: Clinico-Pathological Profile and p16 Immunostaining |
| title_full_unstemmed | Sun-Exposed versus Sun-Protected Cutaneous Basal Cell Carcinoma: Clinico-Pathological Profile and p16 Immunostaining |
| title_short | Sun-Exposed versus Sun-Protected Cutaneous Basal Cell Carcinoma: Clinico-Pathological Profile and p16 Immunostaining |
| title_sort | sun exposed versus sun protected cutaneous basal cell carcinoma clinico pathological profile and p16 immunostaining |
| topic | basal cell carcinoma immunohistochemistry non-melanomcytic p16 skin cancer |
| url | https://www.mdpi.com/2075-4418/13/7/1271 |
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