Dexmedetomidine as anesthetic adjunct for fast tracking and pain control in off-pump coronary artery bypass
Objective: This study was designed to determine the efficacy of dexmedetomidine (a highly selective alpha-2 agonist) in achieving fast tracking and improved postoperative pain control in off-pump coronary artery bypass (OPCAB) patients. Methods: Thirty patients scheduled for elective OPCAB were pros...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Saudi Journal of Anaesthesia |
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| Online Access: | http://www.saudija.org/article.asp?issn=1658-354X;year=2013;volume=7;issue=1;spage=6;epage=8;aulast=Abdel-Meguid |
| _version_ | 1818494772725153792 |
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| author | Mohamed Essam Abdel-Meguid |
| author_facet | Mohamed Essam Abdel-Meguid |
| author_sort | Mohamed Essam Abdel-Meguid |
| collection | DOAJ |
| description | Objective: This study was designed to determine the efficacy of dexmedetomidine (a highly selective alpha-2 agonist) in achieving fast tracking and improved postoperative pain control in off-pump coronary artery bypass (OPCAB) patients. Methods: Thirty patients scheduled for elective OPCAB were prospectively randomized into two groups: Group I (15 patients) started dexmedetomidine at 0.5 ug/kg/hour after the induction of anesthesia; this was reduced to 0.3 ug/kg/hour on admission in the cardiac intensive care unit and continued for 12 hours post extubation. Group II (15 patients) received a similar volume and infusion rate of normal saline. Visual analog scale (VAS) of 10-100 was explained thoroughly to the patients during the preoperative visit. Postoperative pain was managed with morphine. The total dose of morphine was recorded. Extubation time and VAS was recorded every two hours for 12 hours post extubation. Results: Extubation time in group I was 72±8 minutes and 186±22 minutes in group II. Mean total use of narcotics in group II was 23.5±20.7 mg compared to 11.4±6.3 mg in group I. VAS median figures were lower at all data points in group I than in group II. Conclusion: Dexmedetomidine showed an effective and safe profile as an anesthetic adjunct in OPCAB, achieving fast tracking of patients and higher quality of pain control with a lower consumption of narcotics. |
| first_indexed | 2024-12-10T18:11:00Z |
| format | Article |
| id | doaj.art-af26ec1153d54110addbe905703b4932 |
| institution | Directory Open Access Journal |
| issn | 1658-354X |
| language | English |
| last_indexed | 2024-12-10T18:11:00Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Anaesthesia |
| spelling | doaj.art-af26ec1153d54110addbe905703b49322022-12-22T01:38:26ZengWolters Kluwer Medknow PublicationsSaudi Journal of Anaesthesia1658-354X2013-01-01716810.4103/1658-354X.109557Dexmedetomidine as anesthetic adjunct for fast tracking and pain control in off-pump coronary artery bypassMohamed Essam Abdel-MeguidObjective: This study was designed to determine the efficacy of dexmedetomidine (a highly selective alpha-2 agonist) in achieving fast tracking and improved postoperative pain control in off-pump coronary artery bypass (OPCAB) patients. Methods: Thirty patients scheduled for elective OPCAB were prospectively randomized into two groups: Group I (15 patients) started dexmedetomidine at 0.5 ug/kg/hour after the induction of anesthesia; this was reduced to 0.3 ug/kg/hour on admission in the cardiac intensive care unit and continued for 12 hours post extubation. Group II (15 patients) received a similar volume and infusion rate of normal saline. Visual analog scale (VAS) of 10-100 was explained thoroughly to the patients during the preoperative visit. Postoperative pain was managed with morphine. The total dose of morphine was recorded. Extubation time and VAS was recorded every two hours for 12 hours post extubation. Results: Extubation time in group I was 72±8 minutes and 186±22 minutes in group II. Mean total use of narcotics in group II was 23.5±20.7 mg compared to 11.4±6.3 mg in group I. VAS median figures were lower at all data points in group I than in group II. Conclusion: Dexmedetomidine showed an effective and safe profile as an anesthetic adjunct in OPCAB, achieving fast tracking of patients and higher quality of pain control with a lower consumption of narcotics.http://www.saudija.org/article.asp?issn=1658-354X;year=2013;volume=7;issue=1;spage=6;epage=8;aulast=Abdel-MeguidDexmedetomidinefast trackingoff-pump coronary artery bypasspostoperative pain |
| spellingShingle | Mohamed Essam Abdel-Meguid Dexmedetomidine as anesthetic adjunct for fast tracking and pain control in off-pump coronary artery bypass Saudi Journal of Anaesthesia Dexmedetomidine fast tracking off-pump coronary artery bypass postoperative pain |
| title | Dexmedetomidine as anesthetic adjunct for fast tracking and pain control in off-pump coronary artery bypass |
| title_full | Dexmedetomidine as anesthetic adjunct for fast tracking and pain control in off-pump coronary artery bypass |
| title_fullStr | Dexmedetomidine as anesthetic adjunct for fast tracking and pain control in off-pump coronary artery bypass |
| title_full_unstemmed | Dexmedetomidine as anesthetic adjunct for fast tracking and pain control in off-pump coronary artery bypass |
| title_short | Dexmedetomidine as anesthetic adjunct for fast tracking and pain control in off-pump coronary artery bypass |
| title_sort | dexmedetomidine as anesthetic adjunct for fast tracking and pain control in off pump coronary artery bypass |
| topic | Dexmedetomidine fast tracking off-pump coronary artery bypass postoperative pain |
| url | http://www.saudija.org/article.asp?issn=1658-354X;year=2013;volume=7;issue=1;spage=6;epage=8;aulast=Abdel-Meguid |
| work_keys_str_mv | AT mohamedessamabdelmeguid dexmedetomidineasanestheticadjunctforfasttrackingandpaincontrolinoffpumpcoronaryarterybypass |