Effect of N-acetylcysteine with letrozole to induction of ovulation in infertile women with polycystic ovarian syndrome
Background and Objective: Polycystic ovary syndrome (PCOS) is the most endocrine disorder in women. This study was done to determine the effect of N-acetylcysteine with letrozole to induction of ovulation in infertile women with polycystic ovarian syndrome. Methods: This clinical trail study was ca...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | fas |
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Golestan University of Medical Sciences
2016-09-01
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| Series: | مجله دانشگاه علوم پزشکی گرگان |
| Subjects: | |
| Online Access: | http://goums.ac.ir/journal/browse.php?a_code=A-10-1-917&slc_lang=en&sid=1 |
| _version_ | 1811258009120145408 |
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| author | T Dabbaghi Ghale F Mohebbi F Movahed H Pakniat Z Yazdi |
| author_facet | T Dabbaghi Ghale F Mohebbi F Movahed H Pakniat Z Yazdi |
| author_sort | T Dabbaghi Ghale |
| collection | DOAJ |
| description | Background and Objective: Polycystic ovary syndrome (PCOS) is the most endocrine disorder in women. This study was done to determine the effect of N-acetylcysteine with letrozole to induction of ovulation in infertile women with polycystic ovarian syndrome.
Methods: This clinical trail study was carried out on forty PCOS women with normal TSH, prolactin, hysterosalpingographies and normal spermograms. The patients in control group were received letrozole 5 mg/d for 5 days starting at day 3 of the cycle. The patients in interventional group were received letrozole 5 mg/d with NAC 1.2 g/d (group II) for 5 days starting at day 3 of the cycle. On 14th day of cycle, transvaginal ultrasonography was performed to evaluate endometrial thickness and follicles properties. If mature follicle detected, hCG was injected and timed coitus at 12, 36 and 60 hours later advised. β-hCG level was checked on day 16 after hCG injection.
Results: The mean of endometrial thickness and follicles ovulation in hCG injection day was similar in the two groups. The pregnancy rate was 15% and 20% in control and interventional groups, respectively. This difference was not significant. The mean of follicles number was 1.13% and 1.47% in control and interventional groups, respectively. This difference was not significant.
Conclusion: NAC as an adjuvant to letrozole was not effective for ovulation induction in patients with PCOS. |
| first_indexed | 2024-04-12T18:06:31Z |
| format | Article |
| id | doaj.art-af2714f72cd44010bb3d03afb49d59ea |
| institution | Directory Open Access Journal |
| issn | 1562-4765 2008-4080 |
| language | fas |
| last_indexed | 2024-04-12T18:06:31Z |
| publishDate | 2016-09-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی گرگان |
| spelling | doaj.art-af2714f72cd44010bb3d03afb49d59ea2022-12-22T03:21:59ZfasGolestan University of Medical Sciencesمجله دانشگاه علوم پزشکی گرگان1562-47652008-40802016-09-0118316Effect of N-acetylcysteine with letrozole to induction of ovulation in infertile women with polycystic ovarian syndromeT Dabbaghi Ghale0F Mohebbi1F Movahed2H Pakniat3Z Yazdi4 Associate Professor, Department of Obstetrics and Gynecology, Qazvin University of Medical Sciences, Qazvin, Iran. Resident in Obstetrics and Gynecology, Qazvin University of Medical Sciences, Qazvin, Iran. Associate Professor, Department of Obstetrics and Gynecology, Qazvin University of Medical Sciences, Qazvin, Iran. Assistant Professor, Department of Obstetrics and Gynecology, Qazvin University of Medical Sciences, Qazvin, Iran. Associate Professor, Department of Community Medicine, Qazvin University of Medical Sciences, Qazvin, Iran. Background and Objective: Polycystic ovary syndrome (PCOS) is the most endocrine disorder in women. This study was done to determine the effect of N-acetylcysteine with letrozole to induction of ovulation in infertile women with polycystic ovarian syndrome. Methods: This clinical trail study was carried out on forty PCOS women with normal TSH, prolactin, hysterosalpingographies and normal spermograms. The patients in control group were received letrozole 5 mg/d for 5 days starting at day 3 of the cycle. The patients in interventional group were received letrozole 5 mg/d with NAC 1.2 g/d (group II) for 5 days starting at day 3 of the cycle. On 14th day of cycle, transvaginal ultrasonography was performed to evaluate endometrial thickness and follicles properties. If mature follicle detected, hCG was injected and timed coitus at 12, 36 and 60 hours later advised. β-hCG level was checked on day 16 after hCG injection. Results: The mean of endometrial thickness and follicles ovulation in hCG injection day was similar in the two groups. The pregnancy rate was 15% and 20% in control and interventional groups, respectively. This difference was not significant. The mean of follicles number was 1.13% and 1.47% in control and interventional groups, respectively. This difference was not significant. Conclusion: NAC as an adjuvant to letrozole was not effective for ovulation induction in patients with PCOS.http://goums.ac.ir/journal/browse.php?a_code=A-10-1-917&slc_lang=en&sid=1Polycystic ovary syndromeN-acetyl-cysteineOvulationLetrozole |
| spellingShingle | T Dabbaghi Ghale F Mohebbi F Movahed H Pakniat Z Yazdi Effect of N-acetylcysteine with letrozole to induction of ovulation in infertile women with polycystic ovarian syndrome مجله دانشگاه علوم پزشکی گرگان Polycystic ovary syndrome N-acetyl-cysteine Ovulation Letrozole |
| title | Effect of N-acetylcysteine with letrozole to induction of ovulation in infertile women with polycystic ovarian syndrome |
| title_full | Effect of N-acetylcysteine with letrozole to induction of ovulation in infertile women with polycystic ovarian syndrome |
| title_fullStr | Effect of N-acetylcysteine with letrozole to induction of ovulation in infertile women with polycystic ovarian syndrome |
| title_full_unstemmed | Effect of N-acetylcysteine with letrozole to induction of ovulation in infertile women with polycystic ovarian syndrome |
| title_short | Effect of N-acetylcysteine with letrozole to induction of ovulation in infertile women with polycystic ovarian syndrome |
| title_sort | effect of n acetylcysteine with letrozole to induction of ovulation in infertile women with polycystic ovarian syndrome |
| topic | Polycystic ovary syndrome N-acetyl-cysteine Ovulation Letrozole |
| url | http://goums.ac.ir/journal/browse.php?a_code=A-10-1-917&slc_lang=en&sid=1 |
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