Liposomes: Clinical Applications and Potential for Image-Guided Drug Delivery
Liposomes have been extensively studied and are used in the treatment of several diseases. Liposomes improve the therapeutic efficacy by enhancing drug absorption while avoiding or minimizing rapid degradation and side effects, prolonging the biological half-life and reducing toxicity. The unique fe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-01-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/23/2/288 |
| _version_ | 1811281615079342080 |
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| author | Narottam Lamichhane Thirupandiyur S. Udayakumar Warren D. D’Souza Charles B. Simone II Srinivasa R. Raghavan Jerimy Polf Javed Mahmood |
| author_facet | Narottam Lamichhane Thirupandiyur S. Udayakumar Warren D. D’Souza Charles B. Simone II Srinivasa R. Raghavan Jerimy Polf Javed Mahmood |
| author_sort | Narottam Lamichhane |
| collection | DOAJ |
| description | Liposomes have been extensively studied and are used in the treatment of several diseases. Liposomes improve the therapeutic efficacy by enhancing drug absorption while avoiding or minimizing rapid degradation and side effects, prolonging the biological half-life and reducing toxicity. The unique feature of liposomes is that they are biocompatible and biodegradable lipids, and are inert and non-immunogenic. Liposomes can compartmentalize and solubilize both hydrophilic and hydrophobic materials. All these properties of liposomes and their flexibility for surface modification to add targeting moieties make liposomes more attractive candidates for use as drug delivery vehicles. There are many novel liposomal formulations that are in various stages of development, to enhance therapeutic effectiveness of new and established drugs that are in preclinical and clinical trials. Recent developments in multimodality imaging to better diagnose disease and monitor treatments embarked on using liposomes as diagnostic tool. Conjugating liposomes with different labeling probes enables precise localization of these liposomal formulations using various modalities such as PET, SPECT, and MRI. In this review, we will briefly review the clinical applications of liposomal formulation and their potential imaging properties. |
| first_indexed | 2024-04-13T01:36:44Z |
| format | Article |
| id | doaj.art-af28492910ed480d8500d2dfb251e448 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-13T01:36:44Z |
| publishDate | 2018-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-af28492910ed480d8500d2dfb251e4482022-12-22T03:08:21ZengMDPI AGMolecules1420-30492018-01-0123228810.3390/molecules23020288molecules23020288Liposomes: Clinical Applications and Potential for Image-Guided Drug DeliveryNarottam Lamichhane0Thirupandiyur S. Udayakumar1Warren D. D’Souza2Charles B. Simone II3Srinivasa R. Raghavan4Jerimy Polf5Javed Mahmood6Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USADepartment of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USADepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USADepartment of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD 20742, USADepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USADepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USALiposomes have been extensively studied and are used in the treatment of several diseases. Liposomes improve the therapeutic efficacy by enhancing drug absorption while avoiding or minimizing rapid degradation and side effects, prolonging the biological half-life and reducing toxicity. The unique feature of liposomes is that they are biocompatible and biodegradable lipids, and are inert and non-immunogenic. Liposomes can compartmentalize and solubilize both hydrophilic and hydrophobic materials. All these properties of liposomes and their flexibility for surface modification to add targeting moieties make liposomes more attractive candidates for use as drug delivery vehicles. There are many novel liposomal formulations that are in various stages of development, to enhance therapeutic effectiveness of new and established drugs that are in preclinical and clinical trials. Recent developments in multimodality imaging to better diagnose disease and monitor treatments embarked on using liposomes as diagnostic tool. Conjugating liposomes with different labeling probes enables precise localization of these liposomal formulations using various modalities such as PET, SPECT, and MRI. In this review, we will briefly review the clinical applications of liposomal formulation and their potential imaging properties.http://www.mdpi.com/1420-3049/23/2/288liposomesclinical applicationsimage guidanceradioisotopesPETSPECTMRI |
| spellingShingle | Narottam Lamichhane Thirupandiyur S. Udayakumar Warren D. D’Souza Charles B. Simone II Srinivasa R. Raghavan Jerimy Polf Javed Mahmood Liposomes: Clinical Applications and Potential for Image-Guided Drug Delivery Molecules liposomes clinical applications image guidance radioisotopes PET SPECT MRI |
| title | Liposomes: Clinical Applications and Potential for Image-Guided Drug Delivery |
| title_full | Liposomes: Clinical Applications and Potential for Image-Guided Drug Delivery |
| title_fullStr | Liposomes: Clinical Applications and Potential for Image-Guided Drug Delivery |
| title_full_unstemmed | Liposomes: Clinical Applications and Potential for Image-Guided Drug Delivery |
| title_short | Liposomes: Clinical Applications and Potential for Image-Guided Drug Delivery |
| title_sort | liposomes clinical applications and potential for image guided drug delivery |
| topic | liposomes clinical applications image guidance radioisotopes PET SPECT MRI |
| url | http://www.mdpi.com/1420-3049/23/2/288 |
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