Lipid raft-mediated regulation of hyaluronan-CD44 interactions in inflammation and cancer
Hyaluronan is a major component of the extracellular matrix and plays pivotal roles in inflammation and cancer. Hyaluronan oligomers are frequently found in these pathological conditions, in which they exert their effects via association with the transmembrane receptor CD44. Lipid rafts are choleste...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00420/full |
| _version_ | 1811214418316361728 |
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| author | Toshiyuki eMurai |
| author_facet | Toshiyuki eMurai |
| author_sort | Toshiyuki eMurai |
| collection | DOAJ |
| description | Hyaluronan is a major component of the extracellular matrix and plays pivotal roles in inflammation and cancer. Hyaluronan oligomers are frequently found in these pathological conditions, in which they exert their effects via association with the transmembrane receptor CD44. Lipid rafts are cholesterol- and glycosphingolipid-enriched membrane microdomains that may regulate membrane receptors while serving as platforms for transmembrane signaling at the cell surface. This article focuses on the recent discovery that lipid rafts regulate the interaction between CD44 and hyaluronan, which depends largely on hyaluronan’s size. Lipid rafts regulate CD44’s ability to bind hyaluronan in T cells, control the rolling adhesion of lymphocytes on vascular endothelial cells, and regulate hyaluronan- and CD44-mediated cancer cell migration. The implications of these findings for preventing inflammatory disorders and cancer are also discussed. |
| first_indexed | 2024-04-12T06:04:14Z |
| format | Article |
| id | doaj.art-af29009f45924775b8d06ea38893e9e0 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T06:04:14Z |
| publishDate | 2015-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-af29009f45924775b8d06ea38893e9e02022-12-22T03:44:57ZengFrontiers Media S.A.Frontiers in Immunology1664-32242015-08-01610.3389/fimmu.2015.00420140440Lipid raft-mediated regulation of hyaluronan-CD44 interactions in inflammation and cancerToshiyuki eMurai0Osaka UniversityHyaluronan is a major component of the extracellular matrix and plays pivotal roles in inflammation and cancer. Hyaluronan oligomers are frequently found in these pathological conditions, in which they exert their effects via association with the transmembrane receptor CD44. Lipid rafts are cholesterol- and glycosphingolipid-enriched membrane microdomains that may regulate membrane receptors while serving as platforms for transmembrane signaling at the cell surface. This article focuses on the recent discovery that lipid rafts regulate the interaction between CD44 and hyaluronan, which depends largely on hyaluronan’s size. Lipid rafts regulate CD44’s ability to bind hyaluronan in T cells, control the rolling adhesion of lymphocytes on vascular endothelial cells, and regulate hyaluronan- and CD44-mediated cancer cell migration. The implications of these findings for preventing inflammatory disorders and cancer are also discussed.http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00420/fullCholesterolOligosaccharidesmembrane dynamicsectodomain sheddingmembrane raftextracellular matrix remodeling |
| spellingShingle | Toshiyuki eMurai Lipid raft-mediated regulation of hyaluronan-CD44 interactions in inflammation and cancer Frontiers in Immunology Cholesterol Oligosaccharides membrane dynamics ectodomain shedding membrane raft extracellular matrix remodeling |
| title | Lipid raft-mediated regulation of hyaluronan-CD44 interactions in inflammation and cancer |
| title_full | Lipid raft-mediated regulation of hyaluronan-CD44 interactions in inflammation and cancer |
| title_fullStr | Lipid raft-mediated regulation of hyaluronan-CD44 interactions in inflammation and cancer |
| title_full_unstemmed | Lipid raft-mediated regulation of hyaluronan-CD44 interactions in inflammation and cancer |
| title_short | Lipid raft-mediated regulation of hyaluronan-CD44 interactions in inflammation and cancer |
| title_sort | lipid raft mediated regulation of hyaluronan cd44 interactions in inflammation and cancer |
| topic | Cholesterol Oligosaccharides membrane dynamics ectodomain shedding membrane raft extracellular matrix remodeling |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00420/full |
| work_keys_str_mv | AT toshiyukiemurai lipidraftmediatedregulationofhyaluronancd44interactionsininflammationandcancer |