Case report: PSMA PET/CT addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpMRI. A diagnostic challenge
This is a case of [68 Ga]Ga-Prostate-specific membrane antigen (PSMA)-11 PET/CT in a 73-years old patient presenting high Prostate Specific Antigen (PSA) levels despite both multi-parametric magnetic resonance imaging (mpMRI) and 12-core saturation biopsy negative for prostate cancer (Pca). This is...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1101221/full |
| _version_ | 1828040508100837376 |
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| author | Luigia Vetrone Giulia Cuzzani Riccardo Mei Lucia Zanoni Alessandro Bertaccini Lorenzo Bianchi Paolo Castellucci Caterina Gaudiano Alberta Cappelli Francesca Giunchi Stefano Fanti Stefano Fanti |
| author_facet | Luigia Vetrone Giulia Cuzzani Riccardo Mei Lucia Zanoni Alessandro Bertaccini Lorenzo Bianchi Paolo Castellucci Caterina Gaudiano Alberta Cappelli Francesca Giunchi Stefano Fanti Stefano Fanti |
| author_sort | Luigia Vetrone |
| collection | DOAJ |
| description | This is a case of [68 Ga]Ga-Prostate-specific membrane antigen (PSMA)-11 PET/CT in a 73-years old patient presenting high Prostate Specific Antigen (PSA) levels despite both multi-parametric magnetic resonance imaging (mpMRI) and 12-core saturation biopsy negative for prostate cancer (Pca). This is a highly interesting case because, despite the advanced metastatic spread at initial presentation as showed by [68Ga]Ga-PSMA-PET/CT, the primary Pca was detected by none of the diagnostic techniques (12 random sample biopsy, mpMRI, PSMA PET/CT). However, [68Ga]Ga-PSMA-PET/CT showed a suspicious axillary lesion suitable for biopsy, which finally resulted as Pca metastasis. This case report is therefore a brilliant example of how [68Ga]Ga-PSMA-PET/CT optimized patient’s management. |
| first_indexed | 2024-04-10T16:56:41Z |
| format | Article |
| id | doaj.art-af298609877c47ec8741ca9fd834136d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T16:56:41Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-af298609877c47ec8741ca9fd834136d2023-02-07T07:07:34ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-02-011310.3389/fonc.2023.11012211101221Case report: PSMA PET/CT addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpMRI. A diagnostic challengeLuigia Vetrone0Giulia Cuzzani1Riccardo Mei2Lucia Zanoni3Alessandro Bertaccini4Lorenzo Bianchi5Paolo Castellucci6Caterina Gaudiano7Alberta Cappelli8Francesca Giunchi9Stefano Fanti10Stefano Fanti11Nuclear Medicine, Alma Mater Studiorum University of Bologna, Bologna, ItalyNuclear Medicine, Alma Mater Studiorum University of Bologna, Bologna, ItalyNuclear Medicine, Alma Mater Studiorum University of Bologna, Bologna, ItalyNuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyDivision of Urology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyDivision of Urology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyNuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyDepartment of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyDepartment of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyPathology Unit, IRRCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyNuclear Medicine, Alma Mater Studiorum University of Bologna, Bologna, ItalyNuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyThis is a case of [68 Ga]Ga-Prostate-specific membrane antigen (PSMA)-11 PET/CT in a 73-years old patient presenting high Prostate Specific Antigen (PSA) levels despite both multi-parametric magnetic resonance imaging (mpMRI) and 12-core saturation biopsy negative for prostate cancer (Pca). This is a highly interesting case because, despite the advanced metastatic spread at initial presentation as showed by [68Ga]Ga-PSMA-PET/CT, the primary Pca was detected by none of the diagnostic techniques (12 random sample biopsy, mpMRI, PSMA PET/CT). However, [68Ga]Ga-PSMA-PET/CT showed a suspicious axillary lesion suitable for biopsy, which finally resulted as Pca metastasis. This case report is therefore a brilliant example of how [68Ga]Ga-PSMA-PET/CT optimized patient’s management.https://www.frontiersin.org/articles/10.3389/fonc.2023.1101221/full[68Ga]Ga-PSMA-PET/CTprostate cancerstagingmini-invasive biopsymetastatic lymph node |
| spellingShingle | Luigia Vetrone Giulia Cuzzani Riccardo Mei Lucia Zanoni Alessandro Bertaccini Lorenzo Bianchi Paolo Castellucci Caterina Gaudiano Alberta Cappelli Francesca Giunchi Stefano Fanti Stefano Fanti Case report: PSMA PET/CT addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpMRI. A diagnostic challenge Frontiers in Oncology [68Ga]Ga-PSMA-PET/CT prostate cancer staging mini-invasive biopsy metastatic lymph node |
| title | Case report: PSMA PET/CT addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpMRI. A diagnostic challenge |
| title_full | Case report: PSMA PET/CT addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpMRI. A diagnostic challenge |
| title_fullStr | Case report: PSMA PET/CT addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpMRI. A diagnostic challenge |
| title_full_unstemmed | Case report: PSMA PET/CT addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpMRI. A diagnostic challenge |
| title_short | Case report: PSMA PET/CT addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpMRI. A diagnostic challenge |
| title_sort | case report psma pet ct addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpmri a diagnostic challenge |
| topic | [68Ga]Ga-PSMA-PET/CT prostate cancer staging mini-invasive biopsy metastatic lymph node |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1101221/full |
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