Stem cell-derived embryo models: a frontier of human embryology
Studying human development remains difficult due to limited accessibility to human embryonic tissues. Prompted by the availability of human stem cells that share molecular and cellular similarities with embryonic and extraembryonic cells in peri-implantation human embryos, researchers have now succe...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2023-08-01
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| Series: | Medical Review |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/mr-2023-0009 |
| _version_ | 1827158911127388160 |
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| author | Kobayashi Norio Fu Jianping |
| author_facet | Kobayashi Norio Fu Jianping |
| author_sort | Kobayashi Norio |
| collection | DOAJ |
| description | Studying human development remains difficult due to limited accessibility to human embryonic tissues. Prompted by the availability of human stem cells that share molecular and cellular similarities with embryonic and extraembryonic cells in peri-implantation human embryos, researchers have now successfully developed stem cell-based human embryo models that are promising as experimental tools for studying early human development. In this Perspective, we discuss the current progress in mouse and human stem cell-derived embryo models and highlight their promising applications in advancing the fundamental understanding of mammalian development. |
| first_indexed | 2024-03-09T10:51:41Z |
| format | Article |
| id | doaj.art-af29d526cee84bb4b6c2dbd509776f8a |
| institution | Directory Open Access Journal |
| issn | 2749-9642 |
| language | English |
| last_indexed | 2025-03-20T23:48:45Z |
| publishDate | 2023-08-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Medical Review |
| spelling | doaj.art-af29d526cee84bb4b6c2dbd509776f8a2024-08-03T12:32:32ZengDe GruyterMedical Review2749-96422023-08-013434334610.1515/mr-2023-0009Stem cell-derived embryo models: a frontier of human embryologyKobayashi Norio0Fu Jianping1Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USADepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USAStudying human development remains difficult due to limited accessibility to human embryonic tissues. Prompted by the availability of human stem cells that share molecular and cellular similarities with embryonic and extraembryonic cells in peri-implantation human embryos, researchers have now successfully developed stem cell-based human embryo models that are promising as experimental tools for studying early human development. In this Perspective, we discuss the current progress in mouse and human stem cell-derived embryo models and highlight their promising applications in advancing the fundamental understanding of mammalian development.https://doi.org/10.1515/mr-2023-0009embryo modelsembryonic developmentpluripotent stem cells |
| spellingShingle | Kobayashi Norio Fu Jianping Stem cell-derived embryo models: a frontier of human embryology Medical Review embryo models embryonic development pluripotent stem cells |
| title | Stem cell-derived embryo models: a frontier of human embryology |
| title_full | Stem cell-derived embryo models: a frontier of human embryology |
| title_fullStr | Stem cell-derived embryo models: a frontier of human embryology |
| title_full_unstemmed | Stem cell-derived embryo models: a frontier of human embryology |
| title_short | Stem cell-derived embryo models: a frontier of human embryology |
| title_sort | stem cell derived embryo models a frontier of human embryology |
| topic | embryo models embryonic development pluripotent stem cells |
| url | https://doi.org/10.1515/mr-2023-0009 |
| work_keys_str_mv | AT kobayashinorio stemcellderivedembryomodelsafrontierofhumanembryology AT fujianping stemcellderivedembryomodelsafrontierofhumanembryology |