Reversed-phase HPLC retention data in correlation studies with in lipophilicity molecular descriptors of carotenoids
Influence of chemical structure on the lipophilicity of isolated free carotenoids from paprika oleoresin has been studied by QSRR approach (Quantitative structure-retention relationship). The chromatographic behavior of these compounds was investigated by using reversed phase high-pressure...
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| Format: | Article |
| Language: | English |
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Association of Chemical Engineers of Serbia
2013-01-01
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| Series: | Hemijska Industrija |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0367-598X/2013/0367-598X1300010P.pdf |
| _version_ | 1811275660683902976 |
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| author | Podunavac-Kuzmanović Sanja O. Jevrić Lidija R. Tepić Aleksandra N. Šumić Zdravko |
| author_facet | Podunavac-Kuzmanović Sanja O. Jevrić Lidija R. Tepić Aleksandra N. Šumić Zdravko |
| author_sort | Podunavac-Kuzmanović Sanja O. |
| collection | DOAJ |
| description | Influence of chemical structure on the lipophilicity of isolated free
carotenoids from paprika oleoresin has been studied by QSRR approach
(Quantitative structure-retention relationship). The chromatographic behavior
of these compounds was investigated by using reversed phase high-pressure
liquid chromatography (RP HPLC). Retention mechanism has been determined
using the following mobile phase: acetone -water, on reversed - phase column
(SB-C18). A variety of lipophilicity parameters (logP) were calculated by use
of different software products. On the basis of correlations, the nonlinear
structure-activity models were derived between the retention constants, tr
(retention time of investigation compounds), and logP values. Five high
quality QSRR models were found to have a good predictive ability and close
agreement between experimental and predicted values. The study showed that
the retention constants can be used as a measure of lipophilicity of
investigated compounds at a high significant level. [Projekat Ministarstva
nauke Republike Srbije, br. 172012, br. 172014 i br. 31055] |
| first_indexed | 2024-04-12T23:41:57Z |
| format | Article |
| id | doaj.art-af2b82a0df394de096eb71f2b990bec8 |
| institution | Directory Open Access Journal |
| issn | 0367-598X 2217-7426 |
| language | English |
| last_indexed | 2024-04-12T23:41:57Z |
| publishDate | 2013-01-01 |
| publisher | Association of Chemical Engineers of Serbia |
| record_format | Article |
| series | Hemijska Industrija |
| spelling | doaj.art-af2b82a0df394de096eb71f2b990bec82022-12-22T03:11:58ZengAssociation of Chemical Engineers of SerbiaHemijska Industrija0367-598X2217-74262013-01-0167693394010.2298/HEMIND121015010P0367-598X1300010PReversed-phase HPLC retention data in correlation studies with in lipophilicity molecular descriptors of carotenoidsPodunavac-Kuzmanović Sanja O.0Jevrić Lidija R.1Tepić Aleksandra N.2Šumić Zdravko3Faculty of Technology, Novi SadFaculty of Technology, Novi SadFaculty of Technology, Novi SadFaculty of Technology, Novi SadInfluence of chemical structure on the lipophilicity of isolated free carotenoids from paprika oleoresin has been studied by QSRR approach (Quantitative structure-retention relationship). The chromatographic behavior of these compounds was investigated by using reversed phase high-pressure liquid chromatography (RP HPLC). Retention mechanism has been determined using the following mobile phase: acetone -water, on reversed - phase column (SB-C18). A variety of lipophilicity parameters (logP) were calculated by use of different software products. On the basis of correlations, the nonlinear structure-activity models were derived between the retention constants, tr (retention time of investigation compounds), and logP values. Five high quality QSRR models were found to have a good predictive ability and close agreement between experimental and predicted values. The study showed that the retention constants can be used as a measure of lipophilicity of investigated compounds at a high significant level. [Projekat Ministarstva nauke Republike Srbije, br. 172012, br. 172014 i br. 31055]http://www.doiserbia.nb.rs/img/doi/0367-598X/2013/0367-598X1300010P.pdfcarotenoidsRP HPLClipophilicityQSRR |
| spellingShingle | Podunavac-Kuzmanović Sanja O. Jevrić Lidija R. Tepić Aleksandra N. Šumić Zdravko Reversed-phase HPLC retention data in correlation studies with in lipophilicity molecular descriptors of carotenoids Hemijska Industrija carotenoids RP HPLC lipophilicity QSRR |
| title | Reversed-phase HPLC retention data in correlation studies with in lipophilicity molecular descriptors of carotenoids |
| title_full | Reversed-phase HPLC retention data in correlation studies with in lipophilicity molecular descriptors of carotenoids |
| title_fullStr | Reversed-phase HPLC retention data in correlation studies with in lipophilicity molecular descriptors of carotenoids |
| title_full_unstemmed | Reversed-phase HPLC retention data in correlation studies with in lipophilicity molecular descriptors of carotenoids |
| title_short | Reversed-phase HPLC retention data in correlation studies with in lipophilicity molecular descriptors of carotenoids |
| title_sort | reversed phase hplc retention data in correlation studies with in lipophilicity molecular descriptors of carotenoids |
| topic | carotenoids RP HPLC lipophilicity QSRR |
| url | http://www.doiserbia.nb.rs/img/doi/0367-598X/2013/0367-598X1300010P.pdf |
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