The landscape of antibody binding affinity in SARS-CoV-2 Omicron BA.1 evolution

The landscape of antibody binding affinity in SARS-CoV-2 Omicron BA.1 evolution

The Omicron BA.1 variant of SARS-CoV-2 escapes convalescent sera and monoclonal antibodies that are effective against earlier strains of the virus. This immune evasion is largely a consequence of mutations in the BA.1 receptor binding domain (RBD), the major antigenic target of SARS-CoV-2. Previous...

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Bibliographic Details
Main Authors: Alief Moulana, Thomas Dupic, Angela M Phillips, Jeffrey Chang, Anne A Roffler, Allison J Greaney, Tyler N Starr, Jesse D Bloom, Michael M Desai
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-02-01
Series:eLife
Subjects:
SARS-CoV-2
omicron variant
antibody escape
immune evasion
fitness landscape
Online Access:https://elifesciences.org/articles/83442

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