Association of Certain Endothelial Function Indicators with T894G Polymorphism of Endothelial Nitric Oxide Synthase Gene in Patients with Hypothyroidism and Concomitant Chronic Cholecystitis
The association of the T894G endothelial nitric oxide synthase (eNOS) gene polymorphism with certain indicators of endothelial function in patients with hypothyroidism and concomitant chronic non-calculous cholecystitis was investigated. Significant increase by 33.1 % (P = 0.01) of desquamated endot...
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| Format: | Article |
| Language: | English |
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Zaslavsky O.Yu.
2016-03-01
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| Series: | Mìžnarodnij Endokrinologìčnij Žurnal |
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| Online Access: | http://iej.zaslavsky.com.ua/article/view/70935 |
| _version_ | 1819281545323610112 |
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| author | I.V. Prysiazhniuk N.V. Pashkovska |
| author_facet | I.V. Prysiazhniuk N.V. Pashkovska |
| author_sort | I.V. Prysiazhniuk |
| collection | DOAJ |
| description | The association of the T894G endothelial nitric oxide synthase (eNOS) gene polymorphism with certain indicators of endothelial function in patients with hypothyroidism and concomitant chronic non-calculous cholecystitis was investigated. Significant increase by 33.1 % (P = 0.01) of desquamated endothelial cells number in the blood was found in patients with T-allele compared with that of in GG-genotype carriers. Also, the concentration of total nitric oxide stable metabolites was 10.4 % (P = 0.04) higher and the level of nitrate anions in the blood was 10.8 % (P = 0.02) higher than in comparison group. Among patients with hypothyroidism and concomitant chronic cholecystitis, the content of vascular endothelial growth factor was 27.7 % (P = 0.03) higher in T-allele carriers as compared with patients with GG-genotype. |
| first_indexed | 2024-12-24T01:01:24Z |
| format | Article |
| id | doaj.art-af2ca18e745042fe8477efdd0571524a |
| institution | Directory Open Access Journal |
| issn | 2224-0721 2307-1427 |
| language | English |
| last_indexed | 2024-12-24T01:01:24Z |
| publishDate | 2016-03-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Mìžnarodnij Endokrinologìčnij Žurnal |
| spelling | doaj.art-af2ca18e745042fe8477efdd0571524a2022-12-21T17:23:22ZengZaslavsky O.Yu.Mìžnarodnij Endokrinologìčnij Žurnal2224-07212307-14272016-03-01122.74808410.22141/2224-0721.2.74.2016.7093570935Association of Certain Endothelial Function Indicators with T894G Polymorphism of Endothelial Nitric Oxide Synthase Gene in Patients with Hypothyroidism and Concomitant Chronic CholecystitisI.V. Prysiazhniuk0N.V. Pashkovska1Department of Clinical Immunology, Allergology and Endocrinology, Higher State Educational Institution of Ukraine «Bukovinian State Medical University», Chernivtsi, UkraineDepartment of Clinical Immunology, Allergology and Endocrinology, Higher State Educational Institution of Ukraine «Bukovinian State Medical University», Chernivtsi, UkraineThe association of the T894G endothelial nitric oxide synthase (eNOS) gene polymorphism with certain indicators of endothelial function in patients with hypothyroidism and concomitant chronic non-calculous cholecystitis was investigated. Significant increase by 33.1 % (P = 0.01) of desquamated endothelial cells number in the blood was found in patients with T-allele compared with that of in GG-genotype carriers. Also, the concentration of total nitric oxide stable metabolites was 10.4 % (P = 0.04) higher and the level of nitrate anions in the blood was 10.8 % (P = 0.02) higher than in comparison group. Among patients with hypothyroidism and concomitant chronic cholecystitis, the content of vascular endothelial growth factor was 27.7 % (P = 0.03) higher in T-allele carriers as compared with patients with GG-genotype.http://iej.zaslavsky.com.ua/article/view/70935chronic cholecystitishypothyroidismeNOS genevascular endothelial growth factor. |
| spellingShingle | I.V. Prysiazhniuk N.V. Pashkovska Association of Certain Endothelial Function Indicators with T894G Polymorphism of Endothelial Nitric Oxide Synthase Gene in Patients with Hypothyroidism and Concomitant Chronic Cholecystitis Mìžnarodnij Endokrinologìčnij Žurnal chronic cholecystitis hypothyroidism eNOS gene vascular endothelial growth factor. |
| title | Association of Certain Endothelial Function Indicators with T894G Polymorphism of Endothelial Nitric Oxide Synthase Gene in Patients with Hypothyroidism and Concomitant Chronic Cholecystitis |
| title_full | Association of Certain Endothelial Function Indicators with T894G Polymorphism of Endothelial Nitric Oxide Synthase Gene in Patients with Hypothyroidism and Concomitant Chronic Cholecystitis |
| title_fullStr | Association of Certain Endothelial Function Indicators with T894G Polymorphism of Endothelial Nitric Oxide Synthase Gene in Patients with Hypothyroidism and Concomitant Chronic Cholecystitis |
| title_full_unstemmed | Association of Certain Endothelial Function Indicators with T894G Polymorphism of Endothelial Nitric Oxide Synthase Gene in Patients with Hypothyroidism and Concomitant Chronic Cholecystitis |
| title_short | Association of Certain Endothelial Function Indicators with T894G Polymorphism of Endothelial Nitric Oxide Synthase Gene in Patients with Hypothyroidism and Concomitant Chronic Cholecystitis |
| title_sort | association of certain endothelial function indicators with t894g polymorphism of endothelial nitric oxide synthase gene in patients with hypothyroidism and concomitant chronic cholecystitis |
| topic | chronic cholecystitis hypothyroidism eNOS gene vascular endothelial growth factor. |
| url | http://iej.zaslavsky.com.ua/article/view/70935 |
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