Effect of ebastine on serum eosinophil cationic protein levels in patients with bronchial asthma
OBJECTIVE. This study evaluated the effects of ebastine on serum eosinophil cationic protein (ECP) levels in patients with bronchial asthma. PATIENTS. Twenty patients with bronchial asthma and low efficiency of current therapy (11 patients with atopic disease and 9 with non-atopic disease) were enro...
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| Format: | Article |
| Language: | Russian |
| Published: |
Remedium Group LLC
2013-12-01
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| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/1144 |
| _version_ | 1797841236299612160 |
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| author | T. Horiguchi S. Tachikawa J. . Kasahara Y. . Sasaki M. . Hirose M. . Shiga R. Kondo J. Miyazaki M. . Sugiyama |
| author_facet | T. Horiguchi S. Tachikawa J. . Kasahara Y. . Sasaki M. . Hirose M. . Shiga R. Kondo J. Miyazaki M. . Sugiyama |
| author_sort | T. Horiguchi |
| collection | DOAJ |
| description | OBJECTIVE. This study evaluated the effects of ebastine on serum eosinophil cationic protein (ECP) levels in patients with bronchial asthma. PATIENTS. Twenty patients with bronchial asthma and low efficiency of current therapy (11 patients with atopic disease and 9 with non-atopic disease) were enrolled in the study. METHODS. In an open-label design, all patients received ebastine 10 mg/day for 4 weeks and serum ECP levels, peripheral blood eosinophil counts, morning peak expiratory flow rate (PEFR) and thresholds for airway hyper-responsiveness (Dmin in asthgraphy) were determined before and after treatment. RESULTS. Serum ECP levels and peripheral blood eosinophil counts were significantly decreased. No significant change was found in the non-atopic patients, while the serum ECP level was significantly (p |
| first_indexed | 2024-04-09T16:28:54Z |
| format | Article |
| id | doaj.art-af2ee2e7d2d34e5e983b70311bcc159d |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:28:54Z |
| publishDate | 2013-12-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-af2ee2e7d2d34e5e983b70311bcc159d2023-04-23T06:57:13ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902013-12-01011384310.21518/2079-701X-2013-11-38-431144Effect of ebastine on serum eosinophil cationic protein levels in patients with bronchial asthmaT. Horiguchi0S. Tachikawa1J. . Kasahara2Y. . Sasaki3M. . Hirose4M. . Shiga5R. Kondo6J. Miyazaki7M. . Sugiyama8Department of Respiratory Diseases, Second Hospital for Medical Education, Fujita Health University of MedicineDepartment of Respiratory Diseases, Second Hospital for Medical Education, Fujita Health University of MedicineDepartment of Respiratory Diseases, Second Hospital for Medical Education, Fujita Health University of MedicineDepartment of Respiratory Diseases, Second Hospital for Medical Education, Fujita Health University of MedicineDepartment of Respiratory Diseases, Second Hospital for Medical Education, Fujita Health University of MedicineDepartment of Respiratory Diseases, Second Hospital for Medical Education, Fujita Health University of MedicineDepartment of Respiratory Diseases, Second Hospital for Medical Education, Fujita Health University of MedicineDepartment of Respiratory Diseases, Second Hospital for Medical Education, Fujita Health University of MedicineDepartment of Respiratory Diseases, Second Hospital for Medical Education, Fujita Health University of MedicineOBJECTIVE. This study evaluated the effects of ebastine on serum eosinophil cationic protein (ECP) levels in patients with bronchial asthma. PATIENTS. Twenty patients with bronchial asthma and low efficiency of current therapy (11 patients with atopic disease and 9 with non-atopic disease) were enrolled in the study. METHODS. In an open-label design, all patients received ebastine 10 mg/day for 4 weeks and serum ECP levels, peripheral blood eosinophil counts, morning peak expiratory flow rate (PEFR) and thresholds for airway hyper-responsiveness (Dmin in asthgraphy) were determined before and after treatment. RESULTS. Serum ECP levels and peripheral blood eosinophil counts were significantly decreased. No significant change was found in the non-atopic patients, while the serum ECP level was significantly (phttps://www.med-sovet.pro/jour/article/view/1144бронхиальная астмакатионный белок эозинофиловэбастинbronchial asthmaeosinophil cationic proteinebastine |
| spellingShingle | T. Horiguchi S. Tachikawa J. . Kasahara Y. . Sasaki M. . Hirose M. . Shiga R. Kondo J. Miyazaki M. . Sugiyama Effect of ebastine on serum eosinophil cationic protein levels in patients with bronchial asthma Медицинский совет бронхиальная астма катионный белок эозинофилов эбастин bronchial asthma eosinophil cationic protein ebastine |
| title | Effect of ebastine on serum eosinophil cationic protein levels in patients with bronchial asthma |
| title_full | Effect of ebastine on serum eosinophil cationic protein levels in patients with bronchial asthma |
| title_fullStr | Effect of ebastine on serum eosinophil cationic protein levels in patients with bronchial asthma |
| title_full_unstemmed | Effect of ebastine on serum eosinophil cationic protein levels in patients with bronchial asthma |
| title_short | Effect of ebastine on serum eosinophil cationic protein levels in patients with bronchial asthma |
| title_sort | effect of ebastine on serum eosinophil cationic protein levels in patients with bronchial asthma |
| topic | бронхиальная астма катионный белок эозинофилов эбастин bronchial asthma eosinophil cationic protein ebastine |
| url | https://www.med-sovet.pro/jour/article/view/1144 |
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