CRISPR-based functional genomics in human dendritic cells

CRISPR-based functional genomics in human dendritic cells

Dendritic cells (DCs) regulate processes ranging from antitumor and antiviral immunity to host-microbe communication at mucosal surfaces. It remains difficult, however, to genetically manipulate human DCs, limiting our ability to probe how DCs elicit specific immune responses. Here, we develop a CRI...

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Bibliographic Details
Main Authors: Marco Jost, Amy N Jacobson, Jeffrey A Hussmann, Giana Cirolia, Michael A Fischbach, Jonathan S Weissman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
CRISPR
dendritic cells
bacteroides thetaiotaomicron
functional genomics
inter-individual variation
Online Access:https://elifesciences.org/articles/65856

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