Annual Plasma Neurofilament Dynamics Is a Sensitive Biomarker of Disease Activity in Patients with Multiple Sclerosis
<i>Background and Objectives</i>: Neurofilament light chain (NfL) is a sensitive biomarker of neuroaxonal damage. This study aimed to assess the relationship between the annual change in plasma NfL (pNfL) and disease activity in the past year, as defined by the concept no evidence of dis...
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MDPI AG
2023-04-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/5/865 |
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| author | Miriam Fedičová Pavol Mikula Zuzana Gdovinová Marianna Vitková Norbert Žilka Jozef Hanes Lýdia Frigová Jarmila Szilasiová |
| author_facet | Miriam Fedičová Pavol Mikula Zuzana Gdovinová Marianna Vitková Norbert Žilka Jozef Hanes Lýdia Frigová Jarmila Szilasiová |
| author_sort | Miriam Fedičová |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Neurofilament light chain (NfL) is a sensitive biomarker of neuroaxonal damage. This study aimed to assess the relationship between the annual change in plasma NfL (pNfL) and disease activity in the past year, as defined by the concept no evidence of disease activity (NEDA) in a cohort of multiple sclerosis (MS) patients. <i>Materials and Methods:</i> Levels of pNfL (SIMOA) were examined in 141 MS patients and analyzed in relationship to the NEDA-3 status (absence of relapse, disability worsening, and MRI activity) and NEDA-4 (NEDA-3 extended by brain volume loss ≤ 0.4%) during the last 12 months. Patients were divided into two groups: annual pNfL change with an increase of less than 10% (group 1), and pNfL increases of more than 10% (group 2). <i>Results:</i> The mean age of the study participants (<i>n</i> = 141, 61% females) was 42.33 years (SD, 10.17), and the median disability score was 4.0 (3.5–5.0). The ROC analysis showed that a pNfL annual change ≥ 10% correlates with the absence of the NEDA-3 status (<i>p</i> < 0.001; AUC: 0.92), and the absence of the NEDA-4 status (<i>p</i> < 0.001; AUC: 0.839). <i>Conclusions:</i> Annual plasma NfL increases of more than 10% appear to be a useful tool for assessing disease activity in treated MS patients. |
| first_indexed | 2024-03-11T03:31:33Z |
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| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T03:31:33Z |
| publishDate | 2023-04-01 |
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| record_format | Article |
| series | Medicina |
| spelling | doaj.art-af300faefd1541669aed63075b4289cb2023-11-18T02:21:23ZengMDPI AGMedicina1010-660X1648-91442023-04-0159586510.3390/medicina59050865Annual Plasma Neurofilament Dynamics Is a Sensitive Biomarker of Disease Activity in Patients with Multiple SclerosisMiriam Fedičová0Pavol Mikula1Zuzana Gdovinová2Marianna Vitková3Norbert Žilka4Jozef Hanes5Lýdia Frigová6Jarmila Szilasiová7Department of Neurology, Faculty of Medicine, Pavol Jozef Šafárik University, 040 11 Košice, SlovakiaDepartment of Social and Behavioural Medicine, Faculty of Medicine, Pavol Jozef Šafárik University, 040 11 Košice, SlovakiaDepartment of Neurology, Faculty of Medicine, Pavol Jozef Šafárik University, 040 11 Košice, SlovakiaDepartment of Neurology, Faculty of Medicine, Pavol Jozef Šafárik University, 040 11 Košice, SlovakiaInstitute of Neuroimmunology, Slovak Academy of Science, 845 10 Bratislava, SlovakiaInstitute of Neuroimmunology, Slovak Academy of Science, 845 10 Bratislava, SlovakiaMagnetic Resonance Imaging, ProMagnet, 041 91 Košice, SlovakiaDepartment of Neurology, Faculty of Medicine, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia<i>Background and Objectives</i>: Neurofilament light chain (NfL) is a sensitive biomarker of neuroaxonal damage. This study aimed to assess the relationship between the annual change in plasma NfL (pNfL) and disease activity in the past year, as defined by the concept no evidence of disease activity (NEDA) in a cohort of multiple sclerosis (MS) patients. <i>Materials and Methods:</i> Levels of pNfL (SIMOA) were examined in 141 MS patients and analyzed in relationship to the NEDA-3 status (absence of relapse, disability worsening, and MRI activity) and NEDA-4 (NEDA-3 extended by brain volume loss ≤ 0.4%) during the last 12 months. Patients were divided into two groups: annual pNfL change with an increase of less than 10% (group 1), and pNfL increases of more than 10% (group 2). <i>Results:</i> The mean age of the study participants (<i>n</i> = 141, 61% females) was 42.33 years (SD, 10.17), and the median disability score was 4.0 (3.5–5.0). The ROC analysis showed that a pNfL annual change ≥ 10% correlates with the absence of the NEDA-3 status (<i>p</i> < 0.001; AUC: 0.92), and the absence of the NEDA-4 status (<i>p</i> < 0.001; AUC: 0.839). <i>Conclusions:</i> Annual plasma NfL increases of more than 10% appear to be a useful tool for assessing disease activity in treated MS patients.https://www.mdpi.com/1648-9144/59/5/865multiple sclerosisdisease activityneurofilament light chainneurofilament dynamicsNEDA |
| spellingShingle | Miriam Fedičová Pavol Mikula Zuzana Gdovinová Marianna Vitková Norbert Žilka Jozef Hanes Lýdia Frigová Jarmila Szilasiová Annual Plasma Neurofilament Dynamics Is a Sensitive Biomarker of Disease Activity in Patients with Multiple Sclerosis Medicina multiple sclerosis disease activity neurofilament light chain neurofilament dynamics NEDA |
| title | Annual Plasma Neurofilament Dynamics Is a Sensitive Biomarker of Disease Activity in Patients with Multiple Sclerosis |
| title_full | Annual Plasma Neurofilament Dynamics Is a Sensitive Biomarker of Disease Activity in Patients with Multiple Sclerosis |
| title_fullStr | Annual Plasma Neurofilament Dynamics Is a Sensitive Biomarker of Disease Activity in Patients with Multiple Sclerosis |
| title_full_unstemmed | Annual Plasma Neurofilament Dynamics Is a Sensitive Biomarker of Disease Activity in Patients with Multiple Sclerosis |
| title_short | Annual Plasma Neurofilament Dynamics Is a Sensitive Biomarker of Disease Activity in Patients with Multiple Sclerosis |
| title_sort | annual plasma neurofilament dynamics is a sensitive biomarker of disease activity in patients with multiple sclerosis |
| topic | multiple sclerosis disease activity neurofilament light chain neurofilament dynamics NEDA |
| url | https://www.mdpi.com/1648-9144/59/5/865 |
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