Enhancing Checkpoint Inhibitor Therapy in Solid Tissue Cancers: The Role of Diet, the Microbiome & Microbiome-Derived Metabolites

Enhancing Checkpoint Inhibitor Therapy in Solid Tissue Cancers: The Role of Diet, the Microbiome & Microbiome-Derived Metabolites

Host immunity plays a central role in the regulation of anti-tumour responses during checkpoint inhibitor therapy (CIT). The mechanisms involved in long lasting remission remain unclear. Animal studies have revealed that the microbiome influences the host immune response. This is supported by human...

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Bibliographic Details
Main Authors: Agnieszka Beata Malczewski, Natkunam Ketheesan, Jermaine I. G. Coward, Severine Navarro
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
cancer immunotherapy
microbiome
metabolome
checkpoint inhibitor therapy
short chain fatty acids
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.624434/full

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