Assessment of the suitability of selected non-measuring models for dermal exposure estimation for the purposes of assessing compliance of working conditions with restrictions 71 and 76 in Annex XVII of the REACH regulation
Background Occupational exposure to chemicals occurs mainly through inhalation and the skin. The inhalation exposure assessment is regulated by law, while in Poland the method of conducting measurements for dermal exposure has not been indicated in the law. However, due to the restrictions 71 and 76...
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| Format: | Article |
| Language: | English |
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Nofer Institute of Occupational Medicine
2023-12-01
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| Series: | Medycyna Pracy |
| Subjects: | |
| Online Access: | http://medpr.imp.lodz.pl/Ocena-przydatnosci-wybranych-modeli-bezpomiarowych-do-szacowania-narazenia-dermalnego,174766,0,2.html |
| _version_ | 1797371097312657408 |
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| author | Agnieszka Klimecka Małgorzata Kupczewska-Dobecka Katarzyna Konieczko Joanna Jurewicz |
| author_facet | Agnieszka Klimecka Małgorzata Kupczewska-Dobecka Katarzyna Konieczko Joanna Jurewicz |
| author_sort | Agnieszka Klimecka |
| collection | DOAJ |
| description | Background
Occupational exposure to chemicals occurs mainly through inhalation and the skin. The inhalation exposure assessment is regulated by law, while in Poland the method of conducting measurements for dermal exposure has not been indicated in the law. However, due to the restrictions 71 and 76 from Annex XVII of REACH for 1-methyl-2-pyrrolidone (NMP) and N,N -dimethylformamide (DMF), exposure assessment by the dermal route is necessary. These restrictions require to ensure that exposure of workers is below the derived no-effect levels (DNELs) for dermal exposure. The aim of the work was assessment of suitability of selected non-measurement forecasting models for the estimation of dermal occupational exposure to chemicals for the purposes of assessing compliance of working conditions with the restrictions 71 and 76 of the REACH regulation.
Material and Methods
Three tools estimating
dermal exposure, recommended by European Chemical Agency (ECHA), were selected: ECETOC TRA, RISKOFDERM and
IH SkinPerm, which were used to estimate 2 exemplary workplaces.
Results
Results of the estimations of dermal exposure showed
that non-measuring models are useful for fulfilling the obligations under restrictions 71 and 76 of Annex XVII of REACH. The type
of exposure scenario and amount of data available for the workplace are crucial for the selection of the model. The ECETOC TRA was
considered the best model for this type of analysis, whose main advantages are direct comparison of the output data in mg/kg/day
with the DNEL value and use of standardized descriptors system.
Conclusions
Exposure modeling is a good and cheap way to determine
the dermal exposure magnitude at workplaces, also to comply with the requirements of restrictions 71 and 76 of Annex XVII
of REACH. The application of modeling in the case of occupational exposure by the dermal route is one of the solutions when it is
necessary to comply with the DNEL for dermal exposure. Med Pr Work Health Saf. 2023;74(6):487–500. |
| first_indexed | 2024-03-08T18:14:52Z |
| format | Article |
| id | doaj.art-af31499246cd4ccf8fe522e9a3e6a773 |
| institution | Directory Open Access Journal |
| issn | 0465-5893 2353-1339 |
| language | English |
| last_indexed | 2024-03-08T18:14:52Z |
| publishDate | 2023-12-01 |
| publisher | Nofer Institute of Occupational Medicine |
| record_format | Article |
| series | Medycyna Pracy |
| spelling | doaj.art-af31499246cd4ccf8fe522e9a3e6a7732023-12-31T14:33:28ZengNofer Institute of Occupational MedicineMedycyna Pracy0465-58932353-13392023-12-0174648750010.13075/mp.5893.01450174766Assessment of the suitability of selected non-measuring models for dermal exposure estimation for the purposes of assessing compliance of working conditions with restrictions 71 and 76 in Annex XVII of the REACH regulationAgnieszka Klimecka0https://orcid.org/0000-0001-8469-9557Małgorzata Kupczewska-Dobecka1https://orcid.org/0000-0001-9633-9428Katarzyna Konieczko2https://orcid.org/0000-0001-7878-5248Joanna Jurewicz3https://orcid.org/0000-0001-9645-0134Instytut Medycyny Pracy im. prof. dra med. Jerzego Nofera / Nofer Institute of Occupational Medicine, Łódź, Poland (Zakład Bezpieczeństwa Chemicznego / Department of Chemical Safety)Instytut Medycyny Pracy im. prof. dra med. Jerzego Nofera / Nofer Institute of Occupational Medicine, Łódź, Poland (Zakład Bezpieczeństwa Chemicznego / Department of Chemical Safety)Instytut Medycyny Pracy im. prof. dra med. Jerzego Nofera / Nofer Institute of Occupational Medicine, Łódź, Poland (Zakład Bezpieczeństwa Chemicznego / Department of Chemical Safety)Instytut Medycyny Pracy im. prof. dra med. Jerzego Nofera / Nofer Institute of Occupational Medicine, Łódź, Poland (Zakład Bezpieczeństwa Chemicznego / Department of Chemical Safety)Background Occupational exposure to chemicals occurs mainly through inhalation and the skin. The inhalation exposure assessment is regulated by law, while in Poland the method of conducting measurements for dermal exposure has not been indicated in the law. However, due to the restrictions 71 and 76 from Annex XVII of REACH for 1-methyl-2-pyrrolidone (NMP) and N,N -dimethylformamide (DMF), exposure assessment by the dermal route is necessary. These restrictions require to ensure that exposure of workers is below the derived no-effect levels (DNELs) for dermal exposure. The aim of the work was assessment of suitability of selected non-measurement forecasting models for the estimation of dermal occupational exposure to chemicals for the purposes of assessing compliance of working conditions with the restrictions 71 and 76 of the REACH regulation. Material and Methods Three tools estimating dermal exposure, recommended by European Chemical Agency (ECHA), were selected: ECETOC TRA, RISKOFDERM and IH SkinPerm, which were used to estimate 2 exemplary workplaces. Results Results of the estimations of dermal exposure showed that non-measuring models are useful for fulfilling the obligations under restrictions 71 and 76 of Annex XVII of REACH. The type of exposure scenario and amount of data available for the workplace are crucial for the selection of the model. The ECETOC TRA was considered the best model for this type of analysis, whose main advantages are direct comparison of the output data in mg/kg/day with the DNEL value and use of standardized descriptors system. Conclusions Exposure modeling is a good and cheap way to determine the dermal exposure magnitude at workplaces, also to comply with the requirements of restrictions 71 and 76 of Annex XVII of REACH. The application of modeling in the case of occupational exposure by the dermal route is one of the solutions when it is necessary to comply with the DNEL for dermal exposure. Med Pr Work Health Saf. 2023;74(6):487–500.http://medpr.imp.lodz.pl/Ocena-przydatnosci-wybranych-modeli-bezpomiarowych-do-szacowania-narazenia-dermalnego,174766,0,2.htmloccupational exposuredermal exposureexposure assessmentmathematical modelsworkplacednel |
| spellingShingle | Agnieszka Klimecka Małgorzata Kupczewska-Dobecka Katarzyna Konieczko Joanna Jurewicz Assessment of the suitability of selected non-measuring models for dermal exposure estimation for the purposes of assessing compliance of working conditions with restrictions 71 and 76 in Annex XVII of the REACH regulation Medycyna Pracy occupational exposure dermal exposure exposure assessment mathematical models workplace dnel |
| title | Assessment of the suitability of selected non-measuring models for dermal exposure estimation for the purposes of assessing compliance of working conditions with restrictions 71 and 76 in Annex XVII of the REACH regulation |
| title_full | Assessment of the suitability of selected non-measuring models for dermal exposure estimation for the purposes of assessing compliance of working conditions with restrictions 71 and 76 in Annex XVII of the REACH regulation |
| title_fullStr | Assessment of the suitability of selected non-measuring models for dermal exposure estimation for the purposes of assessing compliance of working conditions with restrictions 71 and 76 in Annex XVII of the REACH regulation |
| title_full_unstemmed | Assessment of the suitability of selected non-measuring models for dermal exposure estimation for the purposes of assessing compliance of working conditions with restrictions 71 and 76 in Annex XVII of the REACH regulation |
| title_short | Assessment of the suitability of selected non-measuring models for dermal exposure estimation for the purposes of assessing compliance of working conditions with restrictions 71 and 76 in Annex XVII of the REACH regulation |
| title_sort | assessment of the suitability of selected non measuring models for dermal exposure estimation for the purposes of assessing compliance of working conditions with restrictions 71 and 76 in annex xvii of the reach regulation |
| topic | occupational exposure dermal exposure exposure assessment mathematical models workplace dnel |
| url | http://medpr.imp.lodz.pl/Ocena-przydatnosci-wybranych-modeli-bezpomiarowych-do-szacowania-narazenia-dermalnego,174766,0,2.html |
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