The Role of C-Reactive Protein and Fibrinogen in the Development of Intracerebral Hemorrhage: A Mendelian Randomization Study in European Population
Background: The causal association of C-reactive protein (CRP) and fibrinogen on intracerebral hemorrhage (ICH) remains uncertain. We investigated the causal associations of CRP and fibrinogen with ICH using two-sample Mendelian randomization.Method: We used single-nucleotide polymorphisms associate...
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2021.608714/full |
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| author | Biyan Wang Xiaoyu Zhang Xiaoyu Zhang Di Liu Jie Zhang Mingyang Cao Xin Tian Isinta Elijah Maranga Xiaoni Meng Qiuyue Tian Feifei Tian Weijie Cao Wei Wang Manshu Song Youxin Wang |
| author_facet | Biyan Wang Xiaoyu Zhang Xiaoyu Zhang Di Liu Jie Zhang Mingyang Cao Xin Tian Isinta Elijah Maranga Xiaoni Meng Qiuyue Tian Feifei Tian Weijie Cao Wei Wang Manshu Song Youxin Wang |
| author_sort | Biyan Wang |
| collection | DOAJ |
| description | Background: The causal association of C-reactive protein (CRP) and fibrinogen on intracerebral hemorrhage (ICH) remains uncertain. We investigated the causal associations of CRP and fibrinogen with ICH using two-sample Mendelian randomization.Method: We used single-nucleotide polymorphisms associated with CRP and fibrinogen as instrumental variables. The summary data on ICH were obtained from the International Stroke Genetics Consortium (1,545 cases and 1,481 controls). Two-sample Mendelian randomization estimates were performed to assess with inverse-variance weighted and sensitive analyses methods including the weighted median, the penalized weighted median, pleiotropy residual sum and outlier (MR-PRESSO) approaches. MR-Egger regression was used to explore the pleiotropy.Results: The MR analyses indicated that genetically predicted CRP concentration was not associated with ICH, with an odds ratio (OR) of 1.263 (95% CI = 0.935–1.704, p = 0.127). Besides, genetically predicted fibrinogen concentration was not associated with an increased risk of ICH, with an OR of 0.879 (95% CI = 0.060–18.281; p = 0.933). No evidence of pleiotropic bias was detected by MR-Egger. The findings were overall robust in sensitivity analyses.Conclusions: Our findings did not support that CRP and fibrinogen are causally associated with the risk of ICH. |
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| last_indexed | 2024-12-16T12:15:25Z |
| publishDate | 2021-02-01 |
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| series | Frontiers in Genetics |
| spelling | doaj.art-af33b4a898294b238a8db7ad42d279602022-12-21T22:32:07ZengFrontiers Media S.A.Frontiers in Genetics1664-80212021-02-011210.3389/fgene.2021.608714608714The Role of C-Reactive Protein and Fibrinogen in the Development of Intracerebral Hemorrhage: A Mendelian Randomization Study in European PopulationBiyan Wang0Xiaoyu Zhang1Xiaoyu Zhang2Di Liu3Jie Zhang4Mingyang Cao5Xin Tian6Isinta Elijah Maranga7Xiaoni Meng8Qiuyue Tian9Feifei Tian10Weijie Cao11Wei Wang12Manshu Song13Youxin Wang14Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, ChinaSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, AustraliaBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, ChinaSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, AustraliaSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, AustraliaBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, ChinaBackground: The causal association of C-reactive protein (CRP) and fibrinogen on intracerebral hemorrhage (ICH) remains uncertain. We investigated the causal associations of CRP and fibrinogen with ICH using two-sample Mendelian randomization.Method: We used single-nucleotide polymorphisms associated with CRP and fibrinogen as instrumental variables. The summary data on ICH were obtained from the International Stroke Genetics Consortium (1,545 cases and 1,481 controls). Two-sample Mendelian randomization estimates were performed to assess with inverse-variance weighted and sensitive analyses methods including the weighted median, the penalized weighted median, pleiotropy residual sum and outlier (MR-PRESSO) approaches. MR-Egger regression was used to explore the pleiotropy.Results: The MR analyses indicated that genetically predicted CRP concentration was not associated with ICH, with an odds ratio (OR) of 1.263 (95% CI = 0.935–1.704, p = 0.127). Besides, genetically predicted fibrinogen concentration was not associated with an increased risk of ICH, with an OR of 0.879 (95% CI = 0.060–18.281; p = 0.933). No evidence of pleiotropic bias was detected by MR-Egger. The findings were overall robust in sensitivity analyses.Conclusions: Our findings did not support that CRP and fibrinogen are causally associated with the risk of ICH.https://www.frontiersin.org/articles/10.3389/fgene.2021.608714/fullC-reactive proteinfibrinogensingle-nucleotide polymorphismsMendelian randomizationintracerebral hemorrhage |
| spellingShingle | Biyan Wang Xiaoyu Zhang Xiaoyu Zhang Di Liu Jie Zhang Mingyang Cao Xin Tian Isinta Elijah Maranga Xiaoni Meng Qiuyue Tian Feifei Tian Weijie Cao Wei Wang Manshu Song Youxin Wang The Role of C-Reactive Protein and Fibrinogen in the Development of Intracerebral Hemorrhage: A Mendelian Randomization Study in European Population Frontiers in Genetics C-reactive protein fibrinogen single-nucleotide polymorphisms Mendelian randomization intracerebral hemorrhage |
| title | The Role of C-Reactive Protein and Fibrinogen in the Development of Intracerebral Hemorrhage: A Mendelian Randomization Study in European Population |
| title_full | The Role of C-Reactive Protein and Fibrinogen in the Development of Intracerebral Hemorrhage: A Mendelian Randomization Study in European Population |
| title_fullStr | The Role of C-Reactive Protein and Fibrinogen in the Development of Intracerebral Hemorrhage: A Mendelian Randomization Study in European Population |
| title_full_unstemmed | The Role of C-Reactive Protein and Fibrinogen in the Development of Intracerebral Hemorrhage: A Mendelian Randomization Study in European Population |
| title_short | The Role of C-Reactive Protein and Fibrinogen in the Development of Intracerebral Hemorrhage: A Mendelian Randomization Study in European Population |
| title_sort | role of c reactive protein and fibrinogen in the development of intracerebral hemorrhage a mendelian randomization study in european population |
| topic | C-reactive protein fibrinogen single-nucleotide polymorphisms Mendelian randomization intracerebral hemorrhage |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2021.608714/full |
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