Evaluation of the effectiveness of microneedling with tranexamic acid in comparison with microneedling with vitamin C in the treatment of melasma: A prospective and single‐blind clinical trial
Abstract Background and Aims Melasma is a common skin condition. Microneedling acts as a dermal delivery system that facilitates the penetration of lightening agents such as vitamin C and tranexamic acid (TXA) into the deeper layers of the skin. Therefore, this study aimed to compare the effectivene...
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| Format: | Article |
| Language: | English |
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Wiley
2023-10-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.1636 |
| _version_ | 1797310542743863296 |
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| author | Nader Pazyar Maryam Raeispour Reza Yaghoobi Maryam Seyedtabib |
| author_facet | Nader Pazyar Maryam Raeispour Reza Yaghoobi Maryam Seyedtabib |
| author_sort | Nader Pazyar |
| collection | DOAJ |
| description | Abstract Background and Aims Melasma is a common skin condition. Microneedling acts as a dermal delivery system that facilitates the penetration of lightening agents such as vitamin C and tranexamic acid (TXA) into the deeper layers of the skin. Therefore, this study aimed to compare the effectiveness of microneedling with TXA with microneedling and vitamin C in treating melasma. Methods In patients with melasma, microneedling was performed at 2–3 mm depth. During that, TXA and vitamin C were poured on the skin of each side of the face, and then each ampoule was soaked for 15 min. This method was performed three times in 2‐week intervals, and the results were compared by measuring the Melasma Area and Severity Index (MASI) score before, during, and 2 months after the completion of the treatment. Results The average MASI score in the baseline in the TXA group was 4.61, and in the vitamin C group was 4.58. The average MASI score in the patients treated with TXA in the last treatment session was 2.40, and the group treated with vitamin C was 2.44. The study results showed that the treatment was effective in both groups based on MASI score. Although there was a difference between the responses of the two groups, it was not significant. Conclusion Microneedling with vitamin C and TXA is a safe and effective treatment option without side effects for treating melasma. |
| first_indexed | 2024-03-08T01:44:38Z |
| format | Article |
| id | doaj.art-af33d75da1af4c9bb6d36f71d33c5984 |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-08T01:44:38Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-af33d75da1af4c9bb6d36f71d33c59842024-02-14T13:06:23ZengWileyHealth Science Reports2398-88352023-10-01610n/an/a10.1002/hsr2.1636Evaluation of the effectiveness of microneedling with tranexamic acid in comparison with microneedling with vitamin C in the treatment of melasma: A prospective and single‐blind clinical trialNader Pazyar0Maryam Raeispour1Reza Yaghoobi2Maryam Seyedtabib3Department of Dermatology, School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz IranSchool of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz IranDepartment of Dermatology, School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz IranDepartment of Biostatistics and Epidemiology, School of Public Health Ahvaz Jundishapur University of Medical Sciences Ahvaz IranAbstract Background and Aims Melasma is a common skin condition. Microneedling acts as a dermal delivery system that facilitates the penetration of lightening agents such as vitamin C and tranexamic acid (TXA) into the deeper layers of the skin. Therefore, this study aimed to compare the effectiveness of microneedling with TXA with microneedling and vitamin C in treating melasma. Methods In patients with melasma, microneedling was performed at 2–3 mm depth. During that, TXA and vitamin C were poured on the skin of each side of the face, and then each ampoule was soaked for 15 min. This method was performed three times in 2‐week intervals, and the results were compared by measuring the Melasma Area and Severity Index (MASI) score before, during, and 2 months after the completion of the treatment. Results The average MASI score in the baseline in the TXA group was 4.61, and in the vitamin C group was 4.58. The average MASI score in the patients treated with TXA in the last treatment session was 2.40, and the group treated with vitamin C was 2.44. The study results showed that the treatment was effective in both groups based on MASI score. Although there was a difference between the responses of the two groups, it was not significant. Conclusion Microneedling with vitamin C and TXA is a safe and effective treatment option without side effects for treating melasma.https://doi.org/10.1002/hsr2.1636ascorbic aciddermatologypigmentation disorderstranexamic Acid |
| spellingShingle | Nader Pazyar Maryam Raeispour Reza Yaghoobi Maryam Seyedtabib Evaluation of the effectiveness of microneedling with tranexamic acid in comparison with microneedling with vitamin C in the treatment of melasma: A prospective and single‐blind clinical trial Health Science Reports ascorbic acid dermatology pigmentation disorders tranexamic Acid |
| title | Evaluation of the effectiveness of microneedling with tranexamic acid in comparison with microneedling with vitamin C in the treatment of melasma: A prospective and single‐blind clinical trial |
| title_full | Evaluation of the effectiveness of microneedling with tranexamic acid in comparison with microneedling with vitamin C in the treatment of melasma: A prospective and single‐blind clinical trial |
| title_fullStr | Evaluation of the effectiveness of microneedling with tranexamic acid in comparison with microneedling with vitamin C in the treatment of melasma: A prospective and single‐blind clinical trial |
| title_full_unstemmed | Evaluation of the effectiveness of microneedling with tranexamic acid in comparison with microneedling with vitamin C in the treatment of melasma: A prospective and single‐blind clinical trial |
| title_short | Evaluation of the effectiveness of microneedling with tranexamic acid in comparison with microneedling with vitamin C in the treatment of melasma: A prospective and single‐blind clinical trial |
| title_sort | evaluation of the effectiveness of microneedling with tranexamic acid in comparison with microneedling with vitamin c in the treatment of melasma a prospective and single blind clinical trial |
| topic | ascorbic acid dermatology pigmentation disorders tranexamic Acid |
| url | https://doi.org/10.1002/hsr2.1636 |
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