Norepinephrine Has Dual Effects on Human Colonic Contractions Through Distinct Subtypes of Alpha 1 AdrenoceptorsSummary

Norepinephrine Has Dual Effects on Human Colonic Contractions Through Distinct Subtypes of Alpha 1 AdrenoceptorsSummary

Background & Aims: Colonic musculature contain smooth muscle cells (SMC), interstitial cells of Cajal (ICC), and platelet-derived growth factor receptor α+ cells (PDGFRα+ cells), which are electrically coupled and operate together as the SIP syncytium. PDGFRα+ cells have enriched expression...

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Bibliographic Details
Main Authors: Masaaki Kurahashi, Yoshihiko Kito, Masayasu Hara, Hiromitsu Takeyama, Kenton M. Sanders, Hikaru Hashitani
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
PDGFRα+ Cells
Colonic Motility
Sympathetic Nervous System
α1 Adrenoceptor
SIP Syncytium
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X20300655

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