Role of CCL2/MCP-1 in Islet Transplantation

Role of CCL2/MCP-1 in Islet Transplantation

High levels of donor-derived CCL2 have been associated with poor islet allograft outcome in patients with type 1 diabetes. The aim of our work was to determine whether CCL2 secreted by the islet has independent proinflammatory effects that influence engraftment and graft acceptance. Both in mice and...

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Bibliographic Details
Main Authors:	Raffaella Melzi, Alessia Mercalli, Valeria Sordi, Elisa Cantarelli, Rita Nano, Paola Maffi, Giovanni Sitia, Luca G. Guidotti, Antonio Secchi, Ezio Bonifacio, Lorenzo Piemonti
Format:	Article
Language:	English
Published:	SAGE Publishing 2010-08-01
Series:	Cell Transplantation
Online Access:	https://doi.org/10.3727/096368910X514639

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