Altering endocannabinoid neurotransmission at critical developmental ages: impact on rodent emotionality and cognitive performance
The endocannabinoid system shows functional activity from early stages of brain development: it plays an important role in fundamental developmental processes such as cell proliferation, migration and differentiation, thus shaping brain organization during pre- and postnatal life. Cannabis sativa pr...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-01-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2012.00002/full |
| _version_ | 1818501950980751360 |
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| author | Viviana eTrezza Patrizia eCampolongo Antonia eManduca Maria eMorena Maura ePalmery Louk eVanderschuren Louk eVanderschuren Vincenzo eCuomo |
| author_facet | Viviana eTrezza Patrizia eCampolongo Antonia eManduca Maria eMorena Maura ePalmery Louk eVanderschuren Louk eVanderschuren Vincenzo eCuomo |
| author_sort | Viviana eTrezza |
| collection | DOAJ |
| description | The endocannabinoid system shows functional activity from early stages of brain development: it plays an important role in fundamental developmental processes such as cell proliferation, migration and differentiation, thus shaping brain organization during pre- and postnatal life. Cannabis sativa preparations are among the illicit drugs most commonly used by young people, including pregnant women. The developing brain can be therefore exposed to cannabis preparations during two critical periods: first, in offspring of cannabis-using mothers through perinatal and/or prenatal exposure; second, in adolescent cannabis users during neural maturation. In the last decade, it has become clear that the endocannabinoid system critically modulates memory processing and emotional responses. Therefore, it is well possible that developmental exposure to cannabinoid compounds induces enduring changes in behaviors and neural processes belonging to the cognitive and emotional domains. We address this issue by focusing on rodent studies, in order to provide a framework for understanding the impact of cannabinoid exposure on the developing brain. |
| first_indexed | 2024-12-10T21:03:19Z |
| format | Article |
| id | doaj.art-af366406c4814e1d94b8a00d7110d79c |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-10T21:03:19Z |
| publishDate | 2012-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-af366406c4814e1d94b8a00d7110d79c2022-12-22T01:33:43ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532012-01-01610.3389/fnbeh.2012.0000219297Altering endocannabinoid neurotransmission at critical developmental ages: impact on rodent emotionality and cognitive performanceViviana eTrezza0Patrizia eCampolongo1Antonia eManduca2Maria eMorena3Maura ePalmery4Louk eVanderschuren5Louk eVanderschuren6Vincenzo eCuomo7University Roma TreUniversity of Rome SapienzaUniversity Roma TreUniversity of Rome SapienzaUniversity of Rome SapienzaRudolf Magnus Institute of NeuroscienceUtrecht UniversityUniversity of Rome SapienzaThe endocannabinoid system shows functional activity from early stages of brain development: it plays an important role in fundamental developmental processes such as cell proliferation, migration and differentiation, thus shaping brain organization during pre- and postnatal life. Cannabis sativa preparations are among the illicit drugs most commonly used by young people, including pregnant women. The developing brain can be therefore exposed to cannabis preparations during two critical periods: first, in offspring of cannabis-using mothers through perinatal and/or prenatal exposure; second, in adolescent cannabis users during neural maturation. In the last decade, it has become clear that the endocannabinoid system critically modulates memory processing and emotional responses. Therefore, it is well possible that developmental exposure to cannabinoid compounds induces enduring changes in behaviors and neural processes belonging to the cognitive and emotional domains. We address this issue by focusing on rodent studies, in order to provide a framework for understanding the impact of cannabinoid exposure on the developing brain.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2012.00002/fullBehaviorCannabisCognitionPregnancyadolescencedevelopment |
| spellingShingle | Viviana eTrezza Patrizia eCampolongo Antonia eManduca Maria eMorena Maura ePalmery Louk eVanderschuren Louk eVanderschuren Vincenzo eCuomo Altering endocannabinoid neurotransmission at critical developmental ages: impact on rodent emotionality and cognitive performance Frontiers in Behavioral Neuroscience Behavior Cannabis Cognition Pregnancy adolescence development |
| title | Altering endocannabinoid neurotransmission at critical developmental ages: impact on rodent emotionality and cognitive performance |
| title_full | Altering endocannabinoid neurotransmission at critical developmental ages: impact on rodent emotionality and cognitive performance |
| title_fullStr | Altering endocannabinoid neurotransmission at critical developmental ages: impact on rodent emotionality and cognitive performance |
| title_full_unstemmed | Altering endocannabinoid neurotransmission at critical developmental ages: impact on rodent emotionality and cognitive performance |
| title_short | Altering endocannabinoid neurotransmission at critical developmental ages: impact on rodent emotionality and cognitive performance |
| title_sort | altering endocannabinoid neurotransmission at critical developmental ages impact on rodent emotionality and cognitive performance |
| topic | Behavior Cannabis Cognition Pregnancy adolescence development |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2012.00002/full |
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