Colorectal basidiobolomycosis in a dog
Abstract A 7‐year‐old castrated male French Bulldog was examined for chronic large intestinal enteropathy. A colonic mass and thickened rectal mucosa were identified, and histopathologic examination of endoscopic biopsy specimens disclosed eosinophilic proctitis with large (5‐20 μm), irregularly sha...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-09-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.15859 |
| _version_ | 1818992230143098880 |
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| author | Margaux Marclay Ingeborg M. Langohr Frederic P. Gaschen Aline Rodrigues‐Hoffmann Mariano Carossino Mathew A. Stewart Alexandra N. Myers Amy M. Grooters |
| author_facet | Margaux Marclay Ingeborg M. Langohr Frederic P. Gaschen Aline Rodrigues‐Hoffmann Mariano Carossino Mathew A. Stewart Alexandra N. Myers Amy M. Grooters |
| author_sort | Margaux Marclay |
| collection | DOAJ |
| description | Abstract A 7‐year‐old castrated male French Bulldog was examined for chronic large intestinal enteropathy. A colonic mass and thickened rectal mucosa were identified, and histopathologic examination of endoscopic biopsy specimens disclosed eosinophilic proctitis with large (5‐20 μm), irregularly shaped, pauciseptate hyphae that were Gomori methenamine silver and periodic acid‐Schiff positive. Amplification and sequencing of ribosomal DNA extracted from paraffin‐embedded tissues yielded a sequence with 97% identity to GenBank sequences for Basidiobolus ranarum. After itraconazole, terbinafine, and prednisone administration, clinical signs resolved rapidly, and sonographic lesions were largely absent after 6 weeks. Treatment was discontinued by the owner 15 weeks after diagnosis. Three weeks later, the dog collapsed acutely and was euthanized. Necropsy identified metastatic islet cell carcinoma and grossly unremarkable colorectal tissues. However, histopathology of the rectum disclosed multifocal submucosal granulomas with intralesional hyphae morphologically similar to those previously observed. This report is the first to describe medical treatment of gastrointestinal basidiobolomycosis in a dog. |
| first_indexed | 2024-12-20T20:22:51Z |
| format | Article |
| id | doaj.art-af3af06ff090480a893221e034eee888 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-12-20T20:22:51Z |
| publishDate | 2020-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-af3af06ff090480a893221e034eee8882022-12-21T19:27:31ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762020-09-013452091209510.1111/jvim.15859Colorectal basidiobolomycosis in a dogMargaux Marclay0Ingeborg M. Langohr1Frederic P. Gaschen2Aline Rodrigues‐Hoffmann3Mariano Carossino4Mathew A. Stewart5Alexandra N. Myers6Amy M. Grooters7Department of Veterinary Clinical Sciences Louisiana State University Baton Rouge Louisiana USADepartment of Pathobiological Sciences Louisiana State University Baton Rouge Louisiana USADepartment of Veterinary Clinical Sciences Louisiana State University Baton Rouge Louisiana USADepartment of Veterinary Pathobiology Texas A&M University College Station Texas USADepartment of Pathobiological Sciences Louisiana State University Baton Rouge Louisiana USADepartment of Veterinary Clinical Sciences Louisiana State University Baton Rouge Louisiana USADepartment of Veterinary Pathobiology Texas A&M University College Station Texas USADepartment of Veterinary Clinical Sciences Louisiana State University Baton Rouge Louisiana USAAbstract A 7‐year‐old castrated male French Bulldog was examined for chronic large intestinal enteropathy. A colonic mass and thickened rectal mucosa were identified, and histopathologic examination of endoscopic biopsy specimens disclosed eosinophilic proctitis with large (5‐20 μm), irregularly shaped, pauciseptate hyphae that were Gomori methenamine silver and periodic acid‐Schiff positive. Amplification and sequencing of ribosomal DNA extracted from paraffin‐embedded tissues yielded a sequence with 97% identity to GenBank sequences for Basidiobolus ranarum. After itraconazole, terbinafine, and prednisone administration, clinical signs resolved rapidly, and sonographic lesions were largely absent after 6 weeks. Treatment was discontinued by the owner 15 weeks after diagnosis. Three weeks later, the dog collapsed acutely and was euthanized. Necropsy identified metastatic islet cell carcinoma and grossly unremarkable colorectal tissues. However, histopathology of the rectum disclosed multifocal submucosal granulomas with intralesional hyphae morphologically similar to those previously observed. This report is the first to describe medical treatment of gastrointestinal basidiobolomycosis in a dog.https://doi.org/10.1111/jvim.15859Basidiobolus ranarumentomophthoromycosisitraconazolepythiosiszygomycosis |
| spellingShingle | Margaux Marclay Ingeborg M. Langohr Frederic P. Gaschen Aline Rodrigues‐Hoffmann Mariano Carossino Mathew A. Stewart Alexandra N. Myers Amy M. Grooters Colorectal basidiobolomycosis in a dog Journal of Veterinary Internal Medicine Basidiobolus ranarum entomophthoromycosis itraconazole pythiosis zygomycosis |
| title | Colorectal basidiobolomycosis in a dog |
| title_full | Colorectal basidiobolomycosis in a dog |
| title_fullStr | Colorectal basidiobolomycosis in a dog |
| title_full_unstemmed | Colorectal basidiobolomycosis in a dog |
| title_short | Colorectal basidiobolomycosis in a dog |
| title_sort | colorectal basidiobolomycosis in a dog |
| topic | Basidiobolus ranarum entomophthoromycosis itraconazole pythiosis zygomycosis |
| url | https://doi.org/10.1111/jvim.15859 |
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