Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3
Therapies are needed for the prevention of chondrocyte hypertrophy and thinning of articular cartilage, features of osteoarthritic joint destruction. Here, the authors show that interfering with Sik3 signalling can increase the size of the chondrocyte population and reduce severity of a surgically i...
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Bibliographic Details
| Main Authors: |
Yasuhito Yahara,
Hiroshi Takemori,
Minoru Okada,
Azuma Kosai,
Akihiro Yamashita,
Tomohito Kobayashi,
Kaori Fujita,
Yumi Itoh,
Masahiro Nakamura,
Hiroyuki Fuchino,
Nobuo Kawahara,
Naoshi Fukui,
Akira Watanabe,
Tomoatsu Kimura,
Noriyuki Tsumaki |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2016-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms10959
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