Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3
Therapies are needed for the prevention of chondrocyte hypertrophy and thinning of articular cartilage, features of osteoarthritic joint destruction. Here, the authors show that interfering with Sik3 signalling can increase the size of the chondrocyte population and reduce severity of a surgically i...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10959 |
| _version_ | 1818419818320101376 |
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| author | Yasuhito Yahara Hiroshi Takemori Minoru Okada Azuma Kosai Akihiro Yamashita Tomohito Kobayashi Kaori Fujita Yumi Itoh Masahiro Nakamura Hiroyuki Fuchino Nobuo Kawahara Naoshi Fukui Akira Watanabe Tomoatsu Kimura Noriyuki Tsumaki |
| author_facet | Yasuhito Yahara Hiroshi Takemori Minoru Okada Azuma Kosai Akihiro Yamashita Tomohito Kobayashi Kaori Fujita Yumi Itoh Masahiro Nakamura Hiroyuki Fuchino Nobuo Kawahara Naoshi Fukui Akira Watanabe Tomoatsu Kimura Noriyuki Tsumaki |
| author_sort | Yasuhito Yahara |
| collection | DOAJ |
| description | Therapies are needed for the prevention of chondrocyte hypertrophy and thinning of articular cartilage, features of osteoarthritic joint destruction. Here, the authors show that interfering with Sik3 signalling can increase the size of the chondrocyte population and reduce severity of a surgically induced mouse model of osteoarthritis. |
| first_indexed | 2024-12-14T12:44:37Z |
| format | Article |
| id | doaj.art-af3b32aa0cfb449abeb0966d62633a55 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T12:44:37Z |
| publishDate | 2016-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-af3b32aa0cfb449abeb0966d62633a552022-12-21T23:00:49ZengNature PortfolioNature Communications2041-17232016-03-017111410.1038/ncomms10959Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3Yasuhito Yahara0Hiroshi Takemori1Minoru Okada2Azuma Kosai3Akihiro Yamashita4Tomohito Kobayashi5Kaori Fujita6Yumi Itoh7Masahiro Nakamura8Hiroyuki Fuchino9Nobuo Kawahara10Naoshi Fukui11Akira Watanabe12Tomoatsu Kimura13Noriyuki Tsumaki14Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto UniversityLaboratory of Cell Signaling and Metabolic Disease, National Institutes of Biomedical Innovation, Health and NutritionDepartment of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto UniversityDepartment of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto UniversityDepartment of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto UniversityDepartment of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto UniversityDepartment of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto UniversityLaboratory of Cell Signaling and Metabolic Disease, National Institutes of Biomedical Innovation, Health and NutritionGenome/Epigenome Analysis Core Facility, Center for iPS Cell Research and Application, Kyoto UniversityTsukuba Division, Research Center for Medicinal Plant Resources, National Institutes of Biomedical Innovation, Health and NutritionTsukuba Division, Research Center for Medicinal Plant Resources, National Institutes of Biomedical Innovation, Health and NutritionDepartment of Life Sciences, Graduate School of Arts and Sciences, The University of TokyoGenome/Epigenome Analysis Core Facility, Center for iPS Cell Research and Application, Kyoto UniversityDepartment of Orthopaedic Surgery, Faculty of Medicine, University of ToyamaDepartment of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto UniversityTherapies are needed for the prevention of chondrocyte hypertrophy and thinning of articular cartilage, features of osteoarthritic joint destruction. Here, the authors show that interfering with Sik3 signalling can increase the size of the chondrocyte population and reduce severity of a surgically induced mouse model of osteoarthritis.https://doi.org/10.1038/ncomms10959 |
| spellingShingle | Yasuhito Yahara Hiroshi Takemori Minoru Okada Azuma Kosai Akihiro Yamashita Tomohito Kobayashi Kaori Fujita Yumi Itoh Masahiro Nakamura Hiroyuki Fuchino Nobuo Kawahara Naoshi Fukui Akira Watanabe Tomoatsu Kimura Noriyuki Tsumaki Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 Nature Communications |
| title | Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 |
| title_full | Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 |
| title_fullStr | Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 |
| title_full_unstemmed | Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 |
| title_short | Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 |
| title_sort | pterosin b prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting sik3 |
| url | https://doi.org/10.1038/ncomms10959 |
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