Serum Lutein and Zeaxanthin Are Inversely Associated with High-Sensitivity C-Reactive Protein in Non-Smokers: The Mikkabi Study
Recent randomized controlled trials have demonstrated a protective association between carotenoids and inflammation; however, the basis of this association on lifestyle factors remains unclear. This study aimed to clarify the associations between carotenoids and inflammatory markers stratified by li...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/2/259 |
| _version_ | 1797483284987379712 |
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| author | Mieko Nakamura Minoru Sugiura |
| author_facet | Mieko Nakamura Minoru Sugiura |
| author_sort | Mieko Nakamura |
| collection | DOAJ |
| description | Recent randomized controlled trials have demonstrated a protective association between carotenoids and inflammation; however, the basis of this association on lifestyle factors remains unclear. This study aimed to clarify the associations between carotenoids and inflammatory markers stratified by lifestyle factors, using baseline data from the Mikkabi Study. Serum carotenoid and high-sensitivity C-reactive protein (hs-CRP) levels were measured. Multivariable adjusted odds ratios (ORs) for a high hs-CRP level (≥2.0 mg/dL) were obtained using logistic regression analysis. The data of 882 individuals were analyzed; 11.7% had high hs-CRP levels. The highest tertile of lutein (OR: 0.44; 95% confidence interval [CI]: 0.25–0.76), zeaxanthin (OR: 0.36; 95% CI: 0.21–0.64), total carotenoid (OR: 0.57; 95% CI: 0.32–0.9997), and oxygenated carotenoid concentration (OR: 0.50; 95% CI: 0.28–0.90), with the lowest tertile as reference, was inversely associated with a high hs-CRP level. The interaction between lutein, but not other carotenoids, and current smoking was significant. The inverse association between lutein and a high hs-CRP level was significant in non-smokers (OR: 0.41; 95% CI: 0.22–0.76) but not in smokers. These results further support the anti-inflammatory effect of carotenoids; nevertheless, further studies should clarify the interaction of smoking with the association between lutein and inflammation. |
| first_indexed | 2024-03-09T22:45:44Z |
| format | Article |
| id | doaj.art-af3ea42f79574e04a95a6a6f8b523eda |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T22:45:44Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-af3ea42f79574e04a95a6a6f8b523eda2023-11-23T18:30:54ZengMDPI AGAntioxidants2076-39212022-01-0111225910.3390/antiox11020259Serum Lutein and Zeaxanthin Are Inversely Associated with High-Sensitivity C-Reactive Protein in Non-Smokers: The Mikkabi StudyMieko Nakamura0Minoru Sugiura1Department of Community Health and Preventive Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, JapanDepartment of Food Science and Nutrition, Faculty of Human Life and Science, Doshisha Women’s College of Liberal Arts, Kyoto 602-0893, JapanRecent randomized controlled trials have demonstrated a protective association between carotenoids and inflammation; however, the basis of this association on lifestyle factors remains unclear. This study aimed to clarify the associations between carotenoids and inflammatory markers stratified by lifestyle factors, using baseline data from the Mikkabi Study. Serum carotenoid and high-sensitivity C-reactive protein (hs-CRP) levels were measured. Multivariable adjusted odds ratios (ORs) for a high hs-CRP level (≥2.0 mg/dL) were obtained using logistic regression analysis. The data of 882 individuals were analyzed; 11.7% had high hs-CRP levels. The highest tertile of lutein (OR: 0.44; 95% confidence interval [CI]: 0.25–0.76), zeaxanthin (OR: 0.36; 95% CI: 0.21–0.64), total carotenoid (OR: 0.57; 95% CI: 0.32–0.9997), and oxygenated carotenoid concentration (OR: 0.50; 95% CI: 0.28–0.90), with the lowest tertile as reference, was inversely associated with a high hs-CRP level. The interaction between lutein, but not other carotenoids, and current smoking was significant. The inverse association between lutein and a high hs-CRP level was significant in non-smokers (OR: 0.41; 95% CI: 0.22–0.76) but not in smokers. These results further support the anti-inflammatory effect of carotenoids; nevertheless, further studies should clarify the interaction of smoking with the association between lutein and inflammation.https://www.mdpi.com/2076-3921/11/2/259carotenoidxanthophyllantioxidantinflammationsmoking |
| spellingShingle | Mieko Nakamura Minoru Sugiura Serum Lutein and Zeaxanthin Are Inversely Associated with High-Sensitivity C-Reactive Protein in Non-Smokers: The Mikkabi Study Antioxidants carotenoid xanthophyll antioxidant inflammation smoking |
| title | Serum Lutein and Zeaxanthin Are Inversely Associated with High-Sensitivity C-Reactive Protein in Non-Smokers: The Mikkabi Study |
| title_full | Serum Lutein and Zeaxanthin Are Inversely Associated with High-Sensitivity C-Reactive Protein in Non-Smokers: The Mikkabi Study |
| title_fullStr | Serum Lutein and Zeaxanthin Are Inversely Associated with High-Sensitivity C-Reactive Protein in Non-Smokers: The Mikkabi Study |
| title_full_unstemmed | Serum Lutein and Zeaxanthin Are Inversely Associated with High-Sensitivity C-Reactive Protein in Non-Smokers: The Mikkabi Study |
| title_short | Serum Lutein and Zeaxanthin Are Inversely Associated with High-Sensitivity C-Reactive Protein in Non-Smokers: The Mikkabi Study |
| title_sort | serum lutein and zeaxanthin are inversely associated with high sensitivity c reactive protein in non smokers the mikkabi study |
| topic | carotenoid xanthophyll antioxidant inflammation smoking |
| url | https://www.mdpi.com/2076-3921/11/2/259 |
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