Poly(L-lactic acid) Reinforced with Hydroxyapatite and Tungsten Disulfide Nanotubes
Poly(L-lactic acid) (PLLA) is a biocompatible, biodegradable, and semi-crystalline polymer with numerous applications including food packaging, medical implants, stents, tissue engineering scaffolds, etc. Hydroxyapatite (HA) is the major component of natural bone. Conceptually, combining PLLA and HA...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
|
| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/13/21/3851 |
| _version_ | 1797511942272712704 |
|---|---|
| author | Ofek Golan Hila Shalom Ifat Kaplan-Ashiri Sidney R. Cohen Yishay Feldman Iddo Pinkas Rakefet Ofek Almog Alla Zak Reshef Tenne |
| author_facet | Ofek Golan Hila Shalom Ifat Kaplan-Ashiri Sidney R. Cohen Yishay Feldman Iddo Pinkas Rakefet Ofek Almog Alla Zak Reshef Tenne |
| author_sort | Ofek Golan |
| collection | DOAJ |
| description | Poly(L-lactic acid) (PLLA) is a biocompatible, biodegradable, and semi-crystalline polymer with numerous applications including food packaging, medical implants, stents, tissue engineering scaffolds, etc. Hydroxyapatite (HA) is the major component of natural bone. Conceptually, combining PLLA and HA could produce a bioceramic suitable for implants and bone repair. However, this nanocomposite suffers from poor mechanical behavior under tensile strain. In this study, films of PLLA and HA were prepared with small amounts of nontoxic WS<sub>2</sub> nanotubes (INT-WS<sub>2</sub>). The structural aspects of the films were investigated via electron microscopy, X-ray diffraction, Raman microscopy, and infrared absorption spectroscopy. The mechanical properties were evaluated via tensile measurements, micro-hardness tests, and nanoindentation. The thermal properties were investigated via differential scanning calorimetry. The composite films exhibited improved mechanical and thermal properties compared to the films prepared from the PLLA and HA alone, which is advantageous for medical applications. |
| first_indexed | 2024-03-10T05:54:08Z |
| format | Article |
| id | doaj.art-af3f3912ab2b423cbff7a105a2bb300d |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T05:54:08Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-af3f3912ab2b423cbff7a105a2bb300d2023-11-22T21:29:40ZengMDPI AGPolymers2073-43602021-11-011321385110.3390/polym13213851Poly(L-lactic acid) Reinforced with Hydroxyapatite and Tungsten Disulfide NanotubesOfek Golan0Hila Shalom1Ifat Kaplan-Ashiri2Sidney R. Cohen3Yishay Feldman4Iddo Pinkas5Rakefet Ofek Almog6Alla Zak7Reshef Tenne8Department of Materials Engineering, Azrieli College of Engineering, Jerusalem 9103501, IsraelDepartment of Molecular Chemistry and Materials Science, Weizmann Institute, Rehovot 76100, IsraelChemical Research Support Department, Weizmann Institute, Rehovot 76100, IsraelChemical Research Support Department, Weizmann Institute, Rehovot 76100, IsraelChemical Research Support Department, Weizmann Institute, Rehovot 76100, IsraelChemical Research Support Department, Weizmann Institute, Rehovot 76100, IsraelDepartment of Materials Engineering, Azrieli College of Engineering, Jerusalem 9103501, IsraelDepartment of Sciences, Holon Institute of Technology, Holon 58102, IsraelDepartment of Molecular Chemistry and Materials Science, Weizmann Institute, Rehovot 76100, IsraelPoly(L-lactic acid) (PLLA) is a biocompatible, biodegradable, and semi-crystalline polymer with numerous applications including food packaging, medical implants, stents, tissue engineering scaffolds, etc. Hydroxyapatite (HA) is the major component of natural bone. Conceptually, combining PLLA and HA could produce a bioceramic suitable for implants and bone repair. However, this nanocomposite suffers from poor mechanical behavior under tensile strain. In this study, films of PLLA and HA were prepared with small amounts of nontoxic WS<sub>2</sub> nanotubes (INT-WS<sub>2</sub>). The structural aspects of the films were investigated via electron microscopy, X-ray diffraction, Raman microscopy, and infrared absorption spectroscopy. The mechanical properties were evaluated via tensile measurements, micro-hardness tests, and nanoindentation. The thermal properties were investigated via differential scanning calorimetry. The composite films exhibited improved mechanical and thermal properties compared to the films prepared from the PLLA and HA alone, which is advantageous for medical applications.https://www.mdpi.com/2073-4360/13/21/3851PLLAhydroxyapatiteWS<sub>2</sub> nanotubesbiodegradable polymersmechanical properties |
| spellingShingle | Ofek Golan Hila Shalom Ifat Kaplan-Ashiri Sidney R. Cohen Yishay Feldman Iddo Pinkas Rakefet Ofek Almog Alla Zak Reshef Tenne Poly(L-lactic acid) Reinforced with Hydroxyapatite and Tungsten Disulfide Nanotubes Polymers PLLA hydroxyapatite WS<sub>2</sub> nanotubes biodegradable polymers mechanical properties |
| title | Poly(L-lactic acid) Reinforced with Hydroxyapatite and Tungsten Disulfide Nanotubes |
| title_full | Poly(L-lactic acid) Reinforced with Hydroxyapatite and Tungsten Disulfide Nanotubes |
| title_fullStr | Poly(L-lactic acid) Reinforced with Hydroxyapatite and Tungsten Disulfide Nanotubes |
| title_full_unstemmed | Poly(L-lactic acid) Reinforced with Hydroxyapatite and Tungsten Disulfide Nanotubes |
| title_short | Poly(L-lactic acid) Reinforced with Hydroxyapatite and Tungsten Disulfide Nanotubes |
| title_sort | poly l lactic acid reinforced with hydroxyapatite and tungsten disulfide nanotubes |
| topic | PLLA hydroxyapatite WS<sub>2</sub> nanotubes biodegradable polymers mechanical properties |
| url | https://www.mdpi.com/2073-4360/13/21/3851 |
| work_keys_str_mv | AT ofekgolan polyllacticacidreinforcedwithhydroxyapatiteandtungstendisulfidenanotubes AT hilashalom polyllacticacidreinforcedwithhydroxyapatiteandtungstendisulfidenanotubes AT ifatkaplanashiri polyllacticacidreinforcedwithhydroxyapatiteandtungstendisulfidenanotubes AT sidneyrcohen polyllacticacidreinforcedwithhydroxyapatiteandtungstendisulfidenanotubes AT yishayfeldman polyllacticacidreinforcedwithhydroxyapatiteandtungstendisulfidenanotubes AT iddopinkas polyllacticacidreinforcedwithhydroxyapatiteandtungstendisulfidenanotubes AT rakefetofekalmog polyllacticacidreinforcedwithhydroxyapatiteandtungstendisulfidenanotubes AT allazak polyllacticacidreinforcedwithhydroxyapatiteandtungstendisulfidenanotubes AT resheftenne polyllacticacidreinforcedwithhydroxyapatiteandtungstendisulfidenanotubes |