Scattering-Angle-Resolved Optical Coherence Tomography of a Hypoxic Mouse Retina Model
Several studies have noted a correlation between retinal degeneration and traumatic encephalopathy (TE) making the retina a leading candidate for detection and assessment. Scattering-angle-resolved optical coherence tomography (SAR-OCT) is a candidate imaging modality to detect sub-resolution change...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-03-01
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| Series: | Journal of Experimental Neuroscience |
| Online Access: | https://doi.org/10.1177/1179069519837564 |
| _version_ | 1811337721569869824 |
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| author | Michael R Gardner Ayesha S Rahman Thomas E Milner Henry G Rylander |
| author_facet | Michael R Gardner Ayesha S Rahman Thomas E Milner Henry G Rylander |
| author_sort | Michael R Gardner |
| collection | DOAJ |
| description | Several studies have noted a correlation between retinal degeneration and traumatic encephalopathy (TE) making the retina a leading candidate for detection and assessment. Scattering-angle-resolved optical coherence tomography (SAR-OCT) is a candidate imaging modality to detect sub-resolution changes in retinal microstructure. SAR-OCT images of murine retinas that experience a hypoxic insult—euthanasia by isoflurane overdose—are presented. A total of 4 SAR-OCT measurement parameters are reported in 6 longitudinal experiments: blood flow volume fraction, total retinal thickness, reflectance index, and scattering angle. As each mouse expires, blood flow volume fraction decreases, total retinal thickness increases, reflectance index decreases, and scattering angle diversity increases. Contribution of the retinal vasculature to scattering angle diversity is discussed. Results of this study suggest the utility of SAR-OCT to measure TE using scattering angle diversity contrast in the retina. |
| first_indexed | 2024-04-13T17:59:01Z |
| format | Article |
| id | doaj.art-af3f9442bf974b988167e00c0af3c358 |
| institution | Directory Open Access Journal |
| issn | 1179-0695 |
| language | English |
| last_indexed | 2024-04-13T17:59:01Z |
| publishDate | 2019-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Experimental Neuroscience |
| spelling | doaj.art-af3f9442bf974b988167e00c0af3c3582022-12-22T02:36:19ZengSAGE PublishingJournal of Experimental Neuroscience1179-06952019-03-011310.1177/1179069519837564Scattering-Angle-Resolved Optical Coherence Tomography of a Hypoxic Mouse Retina ModelMichael R Gardner0Ayesha S Rahman1Thomas E Milner2Henry G Rylander3Department of Chemical Engineering, University of Bahrain, Isa Town, BahrainDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USADepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USADepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USASeveral studies have noted a correlation between retinal degeneration and traumatic encephalopathy (TE) making the retina a leading candidate for detection and assessment. Scattering-angle-resolved optical coherence tomography (SAR-OCT) is a candidate imaging modality to detect sub-resolution changes in retinal microstructure. SAR-OCT images of murine retinas that experience a hypoxic insult—euthanasia by isoflurane overdose—are presented. A total of 4 SAR-OCT measurement parameters are reported in 6 longitudinal experiments: blood flow volume fraction, total retinal thickness, reflectance index, and scattering angle. As each mouse expires, blood flow volume fraction decreases, total retinal thickness increases, reflectance index decreases, and scattering angle diversity increases. Contribution of the retinal vasculature to scattering angle diversity is discussed. Results of this study suggest the utility of SAR-OCT to measure TE using scattering angle diversity contrast in the retina.https://doi.org/10.1177/1179069519837564 |
| spellingShingle | Michael R Gardner Ayesha S Rahman Thomas E Milner Henry G Rylander Scattering-Angle-Resolved Optical Coherence Tomography of a Hypoxic Mouse Retina Model Journal of Experimental Neuroscience |
| title | Scattering-Angle-Resolved Optical Coherence Tomography of a Hypoxic Mouse Retina Model |
| title_full | Scattering-Angle-Resolved Optical Coherence Tomography of a Hypoxic Mouse Retina Model |
| title_fullStr | Scattering-Angle-Resolved Optical Coherence Tomography of a Hypoxic Mouse Retina Model |
| title_full_unstemmed | Scattering-Angle-Resolved Optical Coherence Tomography of a Hypoxic Mouse Retina Model |
| title_short | Scattering-Angle-Resolved Optical Coherence Tomography of a Hypoxic Mouse Retina Model |
| title_sort | scattering angle resolved optical coherence tomography of a hypoxic mouse retina model |
| url | https://doi.org/10.1177/1179069519837564 |
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