Overcoming Vascular Barriers to Improve the Theranostic Outcomes of Nanomedicines
Abstract Nanotheranostics aims to utilize nanomaterials to prevent, diagnose, and treat diseases to improve the quality of patients’ lives. Blood vessels are responsible to deliver nutrients and oxygen to the whole body, eliminate waste, and provide access for patrolling immune cells for healthy tis...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-05-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202103148 |
| _version_ | 1818029828703518720 |
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| author | Yufu Tang Zhongzheng Yu Xiaomei Lu Quli Fan Wei Huang |
| author_facet | Yufu Tang Zhongzheng Yu Xiaomei Lu Quli Fan Wei Huang |
| author_sort | Yufu Tang |
| collection | DOAJ |
| description | Abstract Nanotheranostics aims to utilize nanomaterials to prevent, diagnose, and treat diseases to improve the quality of patients’ lives. Blood vessels are responsible to deliver nutrients and oxygen to the whole body, eliminate waste, and provide access for patrolling immune cells for healthy tissues. Meanwhile, they can also nourish disease tissues, spread disease factors or cells into other healthy tissues, and deliver nanotheranostic agents to cover all the regions of a disease tissue. Thus, blood vessels are the first and the most important barrier for highly efficient nanotheranostics. Here, the structure and function of blood vessels are explored and how these characteristics affect nanotheranostics is discussed. Moreover, new mechanisms and related strategies about overcoming vascular obstacles for improved nanotheranostic outcomes are critically summarized, and their merits and demerits of each strategy are analyzed. Moreover, the present challenges to completely exhibit the potential of overcoming vascular barriers to improve the theranostic outcomes of nanomedicines in life science are also discussed. Finally, the future perspective is further discussed. |
| first_indexed | 2024-12-10T05:25:54Z |
| format | Article |
| id | doaj.art-af4160aad4164c41b848255d28d796ac |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-10T05:25:54Z |
| publishDate | 2022-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-af4160aad4164c41b848255d28d796ac2022-12-22T02:00:42ZengWileyAdvanced Science2198-38442022-05-01913n/an/a10.1002/advs.202103148Overcoming Vascular Barriers to Improve the Theranostic Outcomes of NanomedicinesYufu Tang0Zhongzheng Yu1Xiaomei Lu2Quli Fan3Wei Huang4Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) Nanjing Tech University 30 South Puzhu Road Nanjing 211800 P. R. ChinaSchool of Chemical and Biomedical Engineering Nanyang Technological University Singapore 637459 SingaporeKey Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) Nanjing Tech University 30 South Puzhu Road Nanjing 211800 P. R. ChinaKey Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) Nanjing University of Posts and Telecommunications Nanjing 210023 ChinaKey Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) Nanjing Tech University 30 South Puzhu Road Nanjing 211800 P. R. ChinaAbstract Nanotheranostics aims to utilize nanomaterials to prevent, diagnose, and treat diseases to improve the quality of patients’ lives. Blood vessels are responsible to deliver nutrients and oxygen to the whole body, eliminate waste, and provide access for patrolling immune cells for healthy tissues. Meanwhile, they can also nourish disease tissues, spread disease factors or cells into other healthy tissues, and deliver nanotheranostic agents to cover all the regions of a disease tissue. Thus, blood vessels are the first and the most important barrier for highly efficient nanotheranostics. Here, the structure and function of blood vessels are explored and how these characteristics affect nanotheranostics is discussed. Moreover, new mechanisms and related strategies about overcoming vascular obstacles for improved nanotheranostic outcomes are critically summarized, and their merits and demerits of each strategy are analyzed. Moreover, the present challenges to completely exhibit the potential of overcoming vascular barriers to improve the theranostic outcomes of nanomedicines in life science are also discussed. Finally, the future perspective is further discussed.https://doi.org/10.1002/advs.202103148improved theranosticsnanotheranostic agentsvascular obstacles |
| spellingShingle | Yufu Tang Zhongzheng Yu Xiaomei Lu Quli Fan Wei Huang Overcoming Vascular Barriers to Improve the Theranostic Outcomes of Nanomedicines Advanced Science improved theranostics nanotheranostic agents vascular obstacles |
| title | Overcoming Vascular Barriers to Improve the Theranostic Outcomes of Nanomedicines |
| title_full | Overcoming Vascular Barriers to Improve the Theranostic Outcomes of Nanomedicines |
| title_fullStr | Overcoming Vascular Barriers to Improve the Theranostic Outcomes of Nanomedicines |
| title_full_unstemmed | Overcoming Vascular Barriers to Improve the Theranostic Outcomes of Nanomedicines |
| title_short | Overcoming Vascular Barriers to Improve the Theranostic Outcomes of Nanomedicines |
| title_sort | overcoming vascular barriers to improve the theranostic outcomes of nanomedicines |
| topic | improved theranostics nanotheranostic agents vascular obstacles |
| url | https://doi.org/10.1002/advs.202103148 |
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