In silico study of the essential oil compounds of ginger and thyme on Coronavirus-2 receptors
Coronavirus-2 (SARS-Cov-2) is a virus that attacks the respiratory system and causes the Covid-19 pandemic. After the pandemic, prevention and appropriate therapy research continue to be carried out to anticipate the emergence of more dangerous viruses. In line with the culture of consuming herbs th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Universitas Ahmad Dahlan
2023-11-01
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| Series: | Pharmaciana |
| Subjects: | |
| Online Access: | http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/26964/pdf_291 |
| _version_ | 1797295294868619264 |
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| author | Caroline Martha Ervina Mohammad Rizki Fadhil Pratama Maria Anabella Jessica |
| author_facet | Caroline Martha Ervina Mohammad Rizki Fadhil Pratama Maria Anabella Jessica |
| author_sort | Caroline |
| collection | DOAJ |
| description | Coronavirus-2 (SARS-Cov-2) is a virus that attacks the respiratory system and causes the Covid-19 pandemic. After the pandemic, prevention and appropriate therapy research continue to be carried out to anticipate the emergence of more dangerous viruses. In line with the culture of consuming herbs that has arisen due to the effects of the pandemic, in this study, an in silico study was carried out for essential oil compounds produced by ginger and thyme herbs which have been widely consumed by the public. The research aim to find the essential oil content that has the most potential as an antiviral against coronavirus-2. The moleculer docking method was carried out, including ligand preparation, receptor and method validation, and analysis of ligand-receptor binding interactions using the AutoDoc 4.2.6. As comparisons, remdesivir and favipiravir were used. The three components with the most potential based on the calculation of the free energy value, were determined by the ADMET parameters using the ADMETlab 2.0. The results showed that the three components in the essential oil exhibited better interactions when compared to remdesivir and favipiravir at the 3CL protease and spike glycoprotein receptors. The results of the in silico study and ADMET prediction test showed that of the three most potent compounds, α-farnesen was the most potent and safe to use |
| first_indexed | 2024-03-07T21:44:43Z |
| format | Article |
| id | doaj.art-af4265915f904de3b740fb989635cbd2 |
| institution | Directory Open Access Journal |
| issn | 2088-4559 2477-0256 |
| language | English |
| last_indexed | 2024-03-07T21:44:43Z |
| publishDate | 2023-11-01 |
| publisher | Universitas Ahmad Dahlan |
| record_format | Article |
| series | Pharmaciana |
| spelling | doaj.art-af4265915f904de3b740fb989635cbd22024-02-26T02:21:44ZengUniversitas Ahmad DahlanPharmaciana2088-45592477-02562023-11-0113334935710.12928/pharmaciana.v13i3.26964In silico study of the essential oil compounds of ginger and thyme on Coronavirus-2 receptorsCaroline0Martha Ervina1Mohammad Rizki Fadhil Pratama2Maria Anabella Jessica3Faculty of Pharmacy Widya Mandala Catholic UniversityFaculty of Pharmacy Widya Mandala Catholic UniversityFaculty of Health Science, Muhammadiah Palangkaraya UniversityFaculty of Pharmacy Widya Mandala Catholic UniversityCoronavirus-2 (SARS-Cov-2) is a virus that attacks the respiratory system and causes the Covid-19 pandemic. After the pandemic, prevention and appropriate therapy research continue to be carried out to anticipate the emergence of more dangerous viruses. In line with the culture of consuming herbs that has arisen due to the effects of the pandemic, in this study, an in silico study was carried out for essential oil compounds produced by ginger and thyme herbs which have been widely consumed by the public. The research aim to find the essential oil content that has the most potential as an antiviral against coronavirus-2. The moleculer docking method was carried out, including ligand preparation, receptor and method validation, and analysis of ligand-receptor binding interactions using the AutoDoc 4.2.6. As comparisons, remdesivir and favipiravir were used. The three components with the most potential based on the calculation of the free energy value, were determined by the ADMET parameters using the ADMETlab 2.0. The results showed that the three components in the essential oil exhibited better interactions when compared to remdesivir and favipiravir at the 3CL protease and spike glycoprotein receptors. The results of the in silico study and ADMET prediction test showed that of the three most potent compounds, α-farnesen was the most potent and safe to usehttp://journal.uad.ac.id/index.php/PHARMACIANA/article/view/26964/pdf_291moleculer dockingginger and thyme3cl protease |
| spellingShingle | Caroline Martha Ervina Mohammad Rizki Fadhil Pratama Maria Anabella Jessica In silico study of the essential oil compounds of ginger and thyme on Coronavirus-2 receptors Pharmaciana moleculer docking ginger and thyme 3cl protease |
| title | In silico study of the essential oil compounds of ginger and thyme on Coronavirus-2 receptors |
| title_full | In silico study of the essential oil compounds of ginger and thyme on Coronavirus-2 receptors |
| title_fullStr | In silico study of the essential oil compounds of ginger and thyme on Coronavirus-2 receptors |
| title_full_unstemmed | In silico study of the essential oil compounds of ginger and thyme on Coronavirus-2 receptors |
| title_short | In silico study of the essential oil compounds of ginger and thyme on Coronavirus-2 receptors |
| title_sort | in silico study of the essential oil compounds of ginger and thyme on coronavirus 2 receptors |
| topic | moleculer docking ginger and thyme 3cl protease |
| url | http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/26964/pdf_291 |
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