Sleep oscillation-specific associations with Alzheimer’s disease CSF biomarkers: novel roles for sleep spindles and tau
Abstract Background Based on associations between sleep spindles, cognition, and sleep-dependent memory processing, here we evaluated potential relationships between levels of CSF Aβ42, P-tau, and T-tau with sleep spindle density and other biophysical properties of sleep spindles in a sample of cogn...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-02-01
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| Series: | Molecular Neurodegeneration |
| Online Access: | http://link.springer.com/article/10.1186/s13024-019-0309-5 |
| _version_ | 1828962370825748480 |
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| author | Korey Kam Ankit Parekh Ram A. Sharma Andreia Andrade Monica Lewin Bresne Castillo Omonigho M. Bubu Nicholas J. Chua Margo D. Miller Anna E. Mullins Lidia Glodzik Lisa Mosconi Nadia Gosselin Kulkarni Prathamesh Zhe Chen Kaj Blennow Henrik Zetterberg Nisha Bagchi Bianca Cavedoni David M. Rapoport Indu Ayappa Mony J. de Leon Eva Petkova Andrew W. Varga Ricardo S. Osorio |
| author_facet | Korey Kam Ankit Parekh Ram A. Sharma Andreia Andrade Monica Lewin Bresne Castillo Omonigho M. Bubu Nicholas J. Chua Margo D. Miller Anna E. Mullins Lidia Glodzik Lisa Mosconi Nadia Gosselin Kulkarni Prathamesh Zhe Chen Kaj Blennow Henrik Zetterberg Nisha Bagchi Bianca Cavedoni David M. Rapoport Indu Ayappa Mony J. de Leon Eva Petkova Andrew W. Varga Ricardo S. Osorio |
| author_sort | Korey Kam |
| collection | DOAJ |
| description | Abstract Background Based on associations between sleep spindles, cognition, and sleep-dependent memory processing, here we evaluated potential relationships between levels of CSF Aβ42, P-tau, and T-tau with sleep spindle density and other biophysical properties of sleep spindles in a sample of cognitively normal elderly individuals. Methods One-night in-lab nocturnal polysomnography (NPSG) and morning to early afternoon CSF collection were performed to measure CSF Aβ42, P-tau and T-tau. Seven days of actigraphy were collected to assess habitual total sleep time. Results Spindle density during NREM stage 2 (N2) sleep was negatively correlated with CSF Aβ42, P-tau and T-tau. From the three, CSF T-tau was the most significantly associated with spindle density, after adjusting for age, sex and ApoE4. Spindle duration, count and fast spindle density were also negatively correlated with T-tau levels. Sleep duration and other measures of sleep quality were not correlated with spindle characteristics and did not modify the associations between sleep spindle characteristics and the CSF biomarkers of AD. Conclusions Reduced spindles during N2 sleep may represent an early dysfunction related to tau, possibly reflecting axonal damage or altered neuronal tau secretion, rendering it a potentially novel biomarker for early neuronal dysfunction. Given their putative role in memory consolidation and neuroplasticity, sleep spindles may represent a mechanism by which tau impairs memory consolidation, as well as a possible target for therapeutic interventions in cognitive decline. |
| first_indexed | 2024-12-14T10:03:31Z |
| format | Article |
| id | doaj.art-af42f9234cea4a459149c7dbb07b3f99 |
| institution | Directory Open Access Journal |
| issn | 1750-1326 |
| language | English |
| last_indexed | 2024-12-14T10:03:31Z |
| publishDate | 2019-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Neurodegeneration |
| spelling | doaj.art-af42f9234cea4a459149c7dbb07b3f992022-12-21T23:07:12ZengBMCMolecular Neurodegeneration1750-13262019-02-0114111210.1186/s13024-019-0309-5Sleep oscillation-specific associations with Alzheimer’s disease CSF biomarkers: novel roles for sleep spindles and tauKorey Kam0Ankit Parekh1Ram A. Sharma2Andreia Andrade3Monica Lewin4Bresne Castillo5Omonigho M. Bubu6Nicholas J. Chua7Margo D. Miller8Anna E. Mullins9Lidia Glodzik10Lisa Mosconi11Nadia Gosselin12Kulkarni Prathamesh13Zhe Chen14Kaj Blennow15Henrik Zetterberg16Nisha Bagchi17Bianca Cavedoni18David M. Rapoport19Indu Ayappa20Mony J. de Leon21Eva Petkova22Andrew W. Varga23Ricardo S. Osorio24Mount Sinai Integrative Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount SinaiMount Sinai Integrative Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount SinaiDepartment of Psychiatry, NYU School of MedicineDepartment of Psychiatry, NYU School of MedicineNathan Kline Institute for Psychiatric ResearchMount Sinai Integrative Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount SinaiDepartment of Psychiatry, NYU School of MedicineMount Sinai Integrative Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount SinaiDepartment of Psychiatry, NYU School of MedicineMount Sinai Integrative Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount SinaiDepartment of Psychiatry, NYU School of MedicineDepartment of Neurology, Weill Cornell Medical CollegeCenter for Advanced Research in Sleep Medicine (CARSM), Department of Psychology, Hospital du Sacré-Coeur de Montreal, Montreal, Quebec, Canada and Université de MontrealDepartment of Psychiatry, NYU School of MedicineDepartment of Psychiatry, NYU School of MedicineInstitute of Neuroscience and Psychiatry, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of GothenburgInstitute of Neuroscience and Psychiatry, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of GothenburgMount Sinai Integrative Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount SinaiDepartment of Psychiatry, NYU School of MedicineMount Sinai Integrative Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount SinaiMount Sinai Integrative Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount SinaiNathan Kline Institute for Psychiatric ResearchDepartment of Psychiatry, NYU School of MedicineMount Sinai Integrative Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount SinaiDepartment of Psychiatry, NYU School of MedicineAbstract Background Based on associations between sleep spindles, cognition, and sleep-dependent memory processing, here we evaluated potential relationships between levels of CSF Aβ42, P-tau, and T-tau with sleep spindle density and other biophysical properties of sleep spindles in a sample of cognitively normal elderly individuals. Methods One-night in-lab nocturnal polysomnography (NPSG) and morning to early afternoon CSF collection were performed to measure CSF Aβ42, P-tau and T-tau. Seven days of actigraphy were collected to assess habitual total sleep time. Results Spindle density during NREM stage 2 (N2) sleep was negatively correlated with CSF Aβ42, P-tau and T-tau. From the three, CSF T-tau was the most significantly associated with spindle density, after adjusting for age, sex and ApoE4. Spindle duration, count and fast spindle density were also negatively correlated with T-tau levels. Sleep duration and other measures of sleep quality were not correlated with spindle characteristics and did not modify the associations between sleep spindle characteristics and the CSF biomarkers of AD. Conclusions Reduced spindles during N2 sleep may represent an early dysfunction related to tau, possibly reflecting axonal damage or altered neuronal tau secretion, rendering it a potentially novel biomarker for early neuronal dysfunction. Given their putative role in memory consolidation and neuroplasticity, sleep spindles may represent a mechanism by which tau impairs memory consolidation, as well as a possible target for therapeutic interventions in cognitive decline.http://link.springer.com/article/10.1186/s13024-019-0309-5 |
| spellingShingle | Korey Kam Ankit Parekh Ram A. Sharma Andreia Andrade Monica Lewin Bresne Castillo Omonigho M. Bubu Nicholas J. Chua Margo D. Miller Anna E. Mullins Lidia Glodzik Lisa Mosconi Nadia Gosselin Kulkarni Prathamesh Zhe Chen Kaj Blennow Henrik Zetterberg Nisha Bagchi Bianca Cavedoni David M. Rapoport Indu Ayappa Mony J. de Leon Eva Petkova Andrew W. Varga Ricardo S. Osorio Sleep oscillation-specific associations with Alzheimer’s disease CSF biomarkers: novel roles for sleep spindles and tau Molecular Neurodegeneration |
| title | Sleep oscillation-specific associations with Alzheimer’s disease CSF biomarkers: novel roles for sleep spindles and tau |
| title_full | Sleep oscillation-specific associations with Alzheimer’s disease CSF biomarkers: novel roles for sleep spindles and tau |
| title_fullStr | Sleep oscillation-specific associations with Alzheimer’s disease CSF biomarkers: novel roles for sleep spindles and tau |
| title_full_unstemmed | Sleep oscillation-specific associations with Alzheimer’s disease CSF biomarkers: novel roles for sleep spindles and tau |
| title_short | Sleep oscillation-specific associations with Alzheimer’s disease CSF biomarkers: novel roles for sleep spindles and tau |
| title_sort | sleep oscillation specific associations with alzheimer s disease csf biomarkers novel roles for sleep spindles and tau |
| url | http://link.springer.com/article/10.1186/s13024-019-0309-5 |
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