Commitment of Oral-Derived Stem Cells in Dental and Maxillofacial Applications
Tissue engineering is based on the interaction between stem cells, biomaterials and factors delivered in biological niches. Oral tissues have been found to be rich in stem cells from different sources: Stem cells from oral cavity are easily harvestable and have shown a great plasticity towards the m...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-12-01
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| Series: | Dentistry Journal |
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| Online Access: | https://www.mdpi.com/2304-6767/6/4/72 |
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| author | Gianrico Spagnuolo Bruna Codispoti Massimo Marrelli Carlo Rengo Sandro Rengo Marco Tatullo |
| author_facet | Gianrico Spagnuolo Bruna Codispoti Massimo Marrelli Carlo Rengo Sandro Rengo Marco Tatullo |
| author_sort | Gianrico Spagnuolo |
| collection | DOAJ |
| description | Tissue engineering is based on the interaction between stem cells, biomaterials and factors delivered in biological niches. Oral tissues have been found to be rich in stem cells from different sources: Stem cells from oral cavity are easily harvestable and have shown a great plasticity towards the main lineages, specifically towards bone tissues. Dental pulp stem cells (DPSCs) are the most investigated mesenchymal stem cells (MSCs) from dental tissues, however, the oral cavity hosts several other stem cell lineages that have also been reported to be a good alternative in bone tissue engineering. In particular, the newly discovered population of mesenchymal stem cells derived from human periapical inflamed cysts (hPCy-MSCs) have showed very promising properties, including high plasticity toward bone, vascular and neural phenotypes. In this topical review, the authors described the main oral-derived stem cell populations, their most interesting characteristics and their ability towards osteogenic lineage. This review has also investigated the main clinical procedures, reported in the recent literature, involving oral derived-MSCs and biomaterials to get better bone regeneration in dental procedures. The numerous populations of mesenchymal stem cells isolated from oral tissues (DPSCs, SHEDs, PDLSCs, DFSCs, SCAPs, hPCy-MSCs) retain proliferation ability and multipotency; these features are exploited for clinical purposes, including regeneration of injured tissues and local immunomodulation; we reported on the last studies on the proper use of such MSCs within a biological niche and the proper way to storage them for future clinical use. |
| first_indexed | 2024-04-13T01:20:13Z |
| format | Article |
| id | doaj.art-af4772491397402c90ba537f6c50258e |
| institution | Directory Open Access Journal |
| issn | 2304-6767 |
| language | English |
| last_indexed | 2024-04-13T01:20:13Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dentistry Journal |
| spelling | doaj.art-af4772491397402c90ba537f6c50258e2022-12-22T03:08:48ZengMDPI AGDentistry Journal2304-67672018-12-01647210.3390/dj6040072dj6040072Commitment of Oral-Derived Stem Cells in Dental and Maxillofacial ApplicationsGianrico Spagnuolo0Bruna Codispoti1Massimo Marrelli2Carlo Rengo3Sandro Rengo4Marco Tatullo5Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, 80131 Naples, ItalyUnit of Experimental Medicine, Marrelli Health, 88900 Crotone, ItalyUnit of Experimental Medicine, Marrelli Health, 88900 Crotone, ItalyDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, 80131 Naples, ItalyDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, 80131 Naples, ItalyTecnologica Research Institute, Stem Cells Unit, 88900 Crotone, ItalyTissue engineering is based on the interaction between stem cells, biomaterials and factors delivered in biological niches. Oral tissues have been found to be rich in stem cells from different sources: Stem cells from oral cavity are easily harvestable and have shown a great plasticity towards the main lineages, specifically towards bone tissues. Dental pulp stem cells (DPSCs) are the most investigated mesenchymal stem cells (MSCs) from dental tissues, however, the oral cavity hosts several other stem cell lineages that have also been reported to be a good alternative in bone tissue engineering. In particular, the newly discovered population of mesenchymal stem cells derived from human periapical inflamed cysts (hPCy-MSCs) have showed very promising properties, including high plasticity toward bone, vascular and neural phenotypes. In this topical review, the authors described the main oral-derived stem cell populations, their most interesting characteristics and their ability towards osteogenic lineage. This review has also investigated the main clinical procedures, reported in the recent literature, involving oral derived-MSCs and biomaterials to get better bone regeneration in dental procedures. The numerous populations of mesenchymal stem cells isolated from oral tissues (DPSCs, SHEDs, PDLSCs, DFSCs, SCAPs, hPCy-MSCs) retain proliferation ability and multipotency; these features are exploited for clinical purposes, including regeneration of injured tissues and local immunomodulation; we reported on the last studies on the proper use of such MSCs within a biological niche and the proper way to storage them for future clinical use.https://www.mdpi.com/2304-6767/6/4/72oral-derived stem cellsregenerative medicinebone tissuetissue engineering |
| spellingShingle | Gianrico Spagnuolo Bruna Codispoti Massimo Marrelli Carlo Rengo Sandro Rengo Marco Tatullo Commitment of Oral-Derived Stem Cells in Dental and Maxillofacial Applications Dentistry Journal oral-derived stem cells regenerative medicine bone tissue tissue engineering |
| title | Commitment of Oral-Derived Stem Cells in Dental and Maxillofacial Applications |
| title_full | Commitment of Oral-Derived Stem Cells in Dental and Maxillofacial Applications |
| title_fullStr | Commitment of Oral-Derived Stem Cells in Dental and Maxillofacial Applications |
| title_full_unstemmed | Commitment of Oral-Derived Stem Cells in Dental and Maxillofacial Applications |
| title_short | Commitment of Oral-Derived Stem Cells in Dental and Maxillofacial Applications |
| title_sort | commitment of oral derived stem cells in dental and maxillofacial applications |
| topic | oral-derived stem cells regenerative medicine bone tissue tissue engineering |
| url | https://www.mdpi.com/2304-6767/6/4/72 |
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