Treatment outcome of patients having extensively drug-resistant tuberculosis in Gujarat, India
Background: To investigate the factors affecting treatment outcome of extensively drug resistant tuberculosis (XDR-TB) in Gujarat, India. Methods: A prospective, observational study was conducted on patients with XDR TB from January 2012 to October 2016. Details of demography, clinical symptoms, spu...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2017-01-01
|
| Series: | International Journal of Mycobacteriology |
| Subjects: | |
| Online Access: | http://www.ijmyco.org/article.asp?issn=2212-5531;year=2017;volume=6;issue=3;spage=289;epage=295;aulast=Prajapati |
| _version_ | 1819153305697255424 |
|---|---|
| author | Krunal Prajapati Vishal Mishra Mira Desai Rajesh Solanki Purvi Naik |
| author_facet | Krunal Prajapati Vishal Mishra Mira Desai Rajesh Solanki Purvi Naik |
| author_sort | Krunal Prajapati |
| collection | DOAJ |
| description | Background: To investigate the factors affecting treatment outcome of extensively drug resistant tuberculosis (XDR-TB) in Gujarat, India. Methods: A prospective, observational study was conducted on patients with XDR TB from January 2012 to October 2016. Details of demography, clinical symptoms, sputum/culture and radiological examination, drug treatment, adverse drug reactions (ADRs) and treatment outcome were recorded in pretested case record form (CRF). Data was analyzed using Fisher's exact test and paired student's t test. Results: Out of 112 patients, 83 (74%) were men and 29 (26%) were women and majority of belonged to age group of 16 – 45 years. Majority of patients (79%) received standardized treatment. A total of 61 (54%) patients converted to sputum culture negative by 12 months and out of these, 49 turned sputum culture negative within initial 6 months of treatment. Successful treatment outcome was seen in 29 (25.89 %). Age ≤40 years (P<0.05), body mass index > 18.5 (P<0.05) and sputum/culture conversion at three month (P<0.001) were positive predictors for successful treatment outcome, while tobacco chewing habit (P<0.05) and alcohol consumption (P<0.05) were negative predictors for the successful treatment outcome. Out of 83 (74.1 %) patients with unsuccessful treatment outcome, 58 (51.78 %) died, 11 (9.82 %) were defaulter and 10 (8.92 %) were treatment failure. Factors positively associated with death were very low BMI (< 18.5), concomitant diseases and harmful personal habits. Conclusions: Treatment outcome of XDR TB patients is extremely poor with high mortality rate. |
| first_indexed | 2024-12-22T15:03:05Z |
| format | Article |
| id | doaj.art-af49eee9647248f9829748afa68beead |
| institution | Directory Open Access Journal |
| issn | 2212-5531 2212-554X |
| language | English |
| last_indexed | 2024-12-22T15:03:05Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Mycobacteriology |
| spelling | doaj.art-af49eee9647248f9829748afa68beead2022-12-21T18:22:04ZengWolters Kluwer Medknow PublicationsInternational Journal of Mycobacteriology2212-55312212-554X2017-01-016328929510.4103/ijmy.ijmy_59_17Treatment outcome of patients having extensively drug-resistant tuberculosis in Gujarat, IndiaKrunal PrajapatiVishal MishraMira DesaiRajesh SolankiPurvi NaikBackground: To investigate the factors affecting treatment outcome of extensively drug resistant tuberculosis (XDR-TB) in Gujarat, India. Methods: A prospective, observational study was conducted on patients with XDR TB from January 2012 to October 2016. Details of demography, clinical symptoms, sputum/culture and radiological examination, drug treatment, adverse drug reactions (ADRs) and treatment outcome were recorded in pretested case record form (CRF). Data was analyzed using Fisher's exact test and paired student's t test. Results: Out of 112 patients, 83 (74%) were men and 29 (26%) were women and majority of belonged to age group of 16 – 45 years. Majority of patients (79%) received standardized treatment. A total of 61 (54%) patients converted to sputum culture negative by 12 months and out of these, 49 turned sputum culture negative within initial 6 months of treatment. Successful treatment outcome was seen in 29 (25.89 %). Age ≤40 years (P<0.05), body mass index > 18.5 (P<0.05) and sputum/culture conversion at three month (P<0.001) were positive predictors for successful treatment outcome, while tobacco chewing habit (P<0.05) and alcohol consumption (P<0.05) were negative predictors for the successful treatment outcome. Out of 83 (74.1 %) patients with unsuccessful treatment outcome, 58 (51.78 %) died, 11 (9.82 %) were defaulter and 10 (8.92 %) were treatment failure. Factors positively associated with death were very low BMI (< 18.5), concomitant diseases and harmful personal habits. Conclusions: Treatment outcome of XDR TB patients is extremely poor with high mortality rate.http://www.ijmyco.org/article.asp?issn=2212-5531;year=2017;volume=6;issue=3;spage=289;epage=295;aulast=PrajapatiCorrelationextensively drug resistant tuberculosistreatment outcome |
| spellingShingle | Krunal Prajapati Vishal Mishra Mira Desai Rajesh Solanki Purvi Naik Treatment outcome of patients having extensively drug-resistant tuberculosis in Gujarat, India International Journal of Mycobacteriology Correlation extensively drug resistant tuberculosis treatment outcome |
| title | Treatment outcome of patients having extensively drug-resistant tuberculosis in Gujarat, India |
| title_full | Treatment outcome of patients having extensively drug-resistant tuberculosis in Gujarat, India |
| title_fullStr | Treatment outcome of patients having extensively drug-resistant tuberculosis in Gujarat, India |
| title_full_unstemmed | Treatment outcome of patients having extensively drug-resistant tuberculosis in Gujarat, India |
| title_short | Treatment outcome of patients having extensively drug-resistant tuberculosis in Gujarat, India |
| title_sort | treatment outcome of patients having extensively drug resistant tuberculosis in gujarat india |
| topic | Correlation extensively drug resistant tuberculosis treatment outcome |
| url | http://www.ijmyco.org/article.asp?issn=2212-5531;year=2017;volume=6;issue=3;spage=289;epage=295;aulast=Prajapati |
| work_keys_str_mv | AT krunalprajapati treatmentoutcomeofpatientshavingextensivelydrugresistanttuberculosisingujaratindia AT vishalmishra treatmentoutcomeofpatientshavingextensivelydrugresistanttuberculosisingujaratindia AT miradesai treatmentoutcomeofpatientshavingextensivelydrugresistanttuberculosisingujaratindia AT rajeshsolanki treatmentoutcomeofpatientshavingextensivelydrugresistanttuberculosisingujaratindia AT purvinaik treatmentoutcomeofpatientshavingextensivelydrugresistanttuberculosisingujaratindia |