Blood-Brain Barrier: More Contributor to Disruption of Central Nervous System Homeostasis Than Victim in Neurological Disorders
The blood-brain barrier (BBB) is a dynamic but solid shield in the cerebral microvascular system. It plays a pivotal role in maintaining central nervous system (CNS) homeostasis by regulating the exchange of materials between the circulation and the brain and protects the neural tissue from neurotox...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2020.00764/full |
| _version_ | 1828403646491000832 |
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| author | Minjia Xiao Minjia Xiao Zhi Jie Xiao Binbin Yang Ziwei Lan Fang Fang |
| author_facet | Minjia Xiao Minjia Xiao Zhi Jie Xiao Binbin Yang Ziwei Lan Fang Fang |
| author_sort | Minjia Xiao |
| collection | DOAJ |
| description | The blood-brain barrier (BBB) is a dynamic but solid shield in the cerebral microvascular system. It plays a pivotal role in maintaining central nervous system (CNS) homeostasis by regulating the exchange of materials between the circulation and the brain and protects the neural tissue from neurotoxic components as well as pathogens. Here, we discuss the development of the BBB in physiological conditions and then focus on the role of the BBB in cerebrovascular disease, including acute ischemic stroke and intracerebral hemorrhage, and neurodegenerative disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS). Finally, we summarize recent advancements in the development of therapies targeting the BBB and outline future directions and outstanding questions in the field. We propose that BBB dysfunction not only results from, but is causal in the pathogenesis of neurological disorders; the BBB is more a contributor to the disruption of CNS homeostasis than a victim in neurological disorders. |
| first_indexed | 2024-12-10T10:22:37Z |
| format | Article |
| id | doaj.art-af4a02cf0ec24d8eb8a19270ddd5855e |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-10T10:22:37Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-af4a02cf0ec24d8eb8a19270ddd5855e2022-12-22T01:52:49ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2020-08-011410.3389/fnins.2020.00764540353Blood-Brain Barrier: More Contributor to Disruption of Central Nervous System Homeostasis Than Victim in Neurological DisordersMinjia Xiao0Minjia Xiao1Zhi Jie Xiao2Binbin Yang3Ziwei Lan4Fang Fang5Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurology, Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Second Xiangya Hospital, Central South University, Changsha, ChinaThe blood-brain barrier (BBB) is a dynamic but solid shield in the cerebral microvascular system. It plays a pivotal role in maintaining central nervous system (CNS) homeostasis by regulating the exchange of materials between the circulation and the brain and protects the neural tissue from neurotoxic components as well as pathogens. Here, we discuss the development of the BBB in physiological conditions and then focus on the role of the BBB in cerebrovascular disease, including acute ischemic stroke and intracerebral hemorrhage, and neurodegenerative disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS). Finally, we summarize recent advancements in the development of therapies targeting the BBB and outline future directions and outstanding questions in the field. We propose that BBB dysfunction not only results from, but is causal in the pathogenesis of neurological disorders; the BBB is more a contributor to the disruption of CNS homeostasis than a victim in neurological disorders.https://www.frontiersin.org/article/10.3389/fnins.2020.00764/fullblood-brain barrieracute ischemic strokeintracerebral hemorrhageAlzheimer’s diseaseParkinson’s diseasemultiple sclerosis |
| spellingShingle | Minjia Xiao Minjia Xiao Zhi Jie Xiao Binbin Yang Ziwei Lan Fang Fang Blood-Brain Barrier: More Contributor to Disruption of Central Nervous System Homeostasis Than Victim in Neurological Disorders Frontiers in Neuroscience blood-brain barrier acute ischemic stroke intracerebral hemorrhage Alzheimer’s disease Parkinson’s disease multiple sclerosis |
| title | Blood-Brain Barrier: More Contributor to Disruption of Central Nervous System Homeostasis Than Victim in Neurological Disorders |
| title_full | Blood-Brain Barrier: More Contributor to Disruption of Central Nervous System Homeostasis Than Victim in Neurological Disorders |
| title_fullStr | Blood-Brain Barrier: More Contributor to Disruption of Central Nervous System Homeostasis Than Victim in Neurological Disorders |
| title_full_unstemmed | Blood-Brain Barrier: More Contributor to Disruption of Central Nervous System Homeostasis Than Victim in Neurological Disorders |
| title_short | Blood-Brain Barrier: More Contributor to Disruption of Central Nervous System Homeostasis Than Victim in Neurological Disorders |
| title_sort | blood brain barrier more contributor to disruption of central nervous system homeostasis than victim in neurological disorders |
| topic | blood-brain barrier acute ischemic stroke intracerebral hemorrhage Alzheimer’s disease Parkinson’s disease multiple sclerosis |
| url | https://www.frontiersin.org/article/10.3389/fnins.2020.00764/full |
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